دورية أكاديمية
أعرض في EDS

JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport.

التفاصيل البيبلوغرافية
العنوان: JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport.
المؤلفون: Celestino R; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal., Gama JB; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal., Castro-Rodrigues AF; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal., Barbosa DJ; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal.; TOXRUN-Toxicology Research Unit, University Institute of Health Sciences, Advanced Polytechnic and University Cooperative (CESPU), Cooperative of Limited Liability (CRL), Gandra, Portugal., Rocha H; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal., d'Amico EA; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Musacchio A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Carvalho AX; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal., Morais-Cabral JH; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal., Gassmann R; Instituto de Investigação e Inovação em Saúde-i3S, Universidade do Porto, Porto, Portugal.
المصدر: The Journal of cell biology [J Cell Biol] 2022 Aug 01; Vol. 221 (8). Date of Electronic Publication: 2022 Jul 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Rockefeller University Press
مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Cytoplasmic Dyneins*/genetics , Cytoplasmic Dyneins*/metabolism , Kinesins*/genetics , Nerve Tissue Proteins*/genetics , Nerve Tissue Proteins*/metabolism , Organelles*/metabolism, Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Humans ; Sensory Receptor Cells/metabolism
مستخلص: The MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons of vertebrates and invertebrates. How JIP3's interaction with dynein and kinesin-1 contributes to organelle clearance is unclear. We show that human dynein light intermediate chain (DLIC) binds the N-terminal RH1 domain of JIP3, its paralog JIP4, and the lysosomal adaptor RILP. A point mutation in RH1 abrogates DLIC binding without perturbing the interaction between JIP3's RH1 domain and kinesin heavy chain. Characterization of this separation-of-function mutation in Caenorhabditis elegans shows that JIP3-bound dynein is required for organelle clearance in the anterior process of touch receptor neurons. Unlike JIP3 null mutants, JIP3 that cannot bind DLIC causes prominent accumulation of endo-lysosomal organelles at the neurite tip, which is rescued by a disease-associated point mutation in JIP3's leucine zipper that abrogates kinesin light chain binding. These results highlight that RH1 domains are interaction hubs for cytoskeletal motors and suggest that JIP3-bound dynein and kinesin-1 participate in bidirectional organelle transport.
(© 2022 Celestino et al.)
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معلومات مُعتمدة: P40 OD010440 United States OD NIH HHS; PTDC/BIA-CEL/30507/2017 Fundação para a Ciência e a Tecnologia; P40 OD010440 United States RI ORIP NIH HHS; Oklahoma Medical Research Foundation
المشرفين على المادة: 0 (Adaptor Proteins, Signal Transducing)
0 (KIF5B protein, human)
0 (MAPK8IP3 protein, human)
0 (Nerve Tissue Proteins)
EC 3.6.1.- (DYNC1LI1 protein, human)
EC 3.6.4.2 (Cytoplasmic Dyneins)
EC 3.6.4.4 (Kinesins)
تواريخ الأحداث: Date Created: 20220713 Date Completed: 20220715 Latest Revision: 20240831
رمز التحديث: 20240831
مُعرف محوري في PubMed: PMC9284427
DOI: 10.1083/jcb.202110057
PMID: 35829703
قاعدة البيانات: MEDLINE
الوصف
تدمد:1540-8140
DOI:10.1083/jcb.202110057