دورية أكاديمية
Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study.
| العنوان: | Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study. |
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| المؤلفون: | Toczyłowski K; Department of Pediatric Infectious Diseases, Medical University of Białystok, Waszyngtona 17, 15-274 Białystok, Poland., Łasecka-Zadrożna J; Department of Pediatrics and Infectious Diseases, Regional Hospital in Szczecin, Szczecin, Poland., Pałyga-Bysiecka I; Collegium Medicum University of Jan Kochanowski, ul. Grunwaldzka 45, 25-736 Kielce, Poland., Ludwikowska KM; Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368 Wroclaw, Poland., Okarska-Napierała M; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland., Dudek N; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland., Afelt A; Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland; Espace-DEV, IRD - Institut de Recherche pour le Développement, 500 rue Jean-François Breton - 34393 Montpellier Cedex 05, France., Suski C; Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland., Kursa MB; Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Pawinskiego 5A, 02-106, Warsaw, Poland., Jackowska T; Department of Pediatrics, The Medical Centre of Postgraduate Education, Cegłowska 80, 01-809 Warsaw, Poland., Kuchar E; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland., Szenborn L; Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368 Wroclaw, Poland., Mazur-Melewska K; Department of Infectious Diseases and Child Neurology, Poznań University of Medical Sciences, Szpitalna 27/33; 60-581 Poznań, Poland. Electronic address: katarzynamelewska@ump.edu.pl. |
| مؤلفون مشاركون: | MOIS-CoR Group |
| المصدر: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2022 Sep; Vol. 122, pp. 703-709. Date of Electronic Publication: 2022 Jul 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| مواضيع طبية MeSH: | COVID-19*/complications , COVID-19 Drug Treatment*, Anti-Bacterial Agents/therapeutic use ; Child ; Humans ; Poland/epidemiology ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/drug therapy |
| مستخلص: | Objectives: Multisystem inflammatory syndrome in children (MIS-C) is the result of an immune response triggered by a previous exposure to SARS-CoV-2. The clinical presentation of MIS-C overlaps with other life-threatening bacterial infections, in which antimicrobials are the mainstay therapy. The aim of study was to describe the use of antibiotics in children with MIS-C in Poland. Methods: The analysis of 345 children reported from 42 Polish cities to the national MultiOrgan Inflammatory Syndromes COVID-19 Related Study (MOIS-CoR Study) from June 2020 to April 2021. Results: At least one antibiotic was used in 310 (90%) children, mainly third-generation cephalosporin (251/310). Broad-spectrum antibiotics were used in 258 (75%) children and 224 (87%) received this treatment for more than 3 days. Concentrations of serum procalcitonin >2 µg/l and the presence of lower respiratory symptoms were associated with increased odds of receiving any antibiotic. Conclusion: Although bacterial infections in patients with MIS-C are uncommon, we show that MIS-C poses a challenge to clinicians who are faced with the decision to start, continue, or stop antimicrobial therapy. Antibiotic stewardship in patients with MIS-C should be improved to ensure that likely pathogens are treated and that antimicrobials are stopped when bacterial infections are excluded and the diagnosis of MIS-C is made. Competing Interests: Conflict of interest The authors have no competing interests to declare. (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
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| فهرسة مساهمة: | Investigator: M Sawicka, Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368 Wroclaw, Poland.; E Berdej Szczot, Department of Paediatrics and Paediatric Endocrinology, Upper-Silesian Paediatric Health Center School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.; S Brzuszkiewicz, Provincial Specialist Children's Hospital Prof. S. Popowski in Olsztyn, ul. Żołnierska, 18a, 10-651 Olsztyn, Poland.; P Buda, Department of Pediatrics, Nutrition and Metabolic Diseases, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.; A Czajka, Department of Pediatrics, Children's Hospital, ul. Niekłańska 4/24, 03-924, Warsaw, Poland.; A Czech, Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368 Wroclaw, Poland.; E Czerwińska, Department of Pediatric Infectious Diseases, Wroclaw Medical University, Chałubińskiego 2-2a, 50-368 Wroclaw, Poland.; M Figlerowicz, Department of Infectious Diseases and Child Neurology, Poznań University of Medical Sciences, Szpitalna 27/33; 60-581 Poznań, Poland.; M Firek Pędras, Department of Paediatrics and Paediatric Endocrinology, Upper-Silesian Paediatric Health Center School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.; A Gawlik, Department of Paediatrics and Paediatric Endocrinology, Upper-Silesian Paediatric Health Center School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.; E Gowin, Department of Preventive Health, Poznań University of Medical Science, Smoluchowskiego 11, 60-179, Poznan, Poland; Infectious Diseases Ward, Greater Poland Children's Health Centre; Wrzoska 1, 60-663, Poznań, Poland.; O Izdebska, Clinical Department of Paediatrics and Nephrology, Voivodeship Complex Hospital L. Rydygiera in Toruń, ul. św. Józefa 53-59, 87-100, Toruń, Poland.; D Januszkiewicz Lewandowska, Department of Pediatric Oncology, Hematology and Transplantation, Poznań University of Medical Sciences, Szpitalna 27/33, 60-572, Poznan, Poland.; J Kiepuszka, Specialist Hospital F. Ceynowy, ul. dr. A. Jagalskiego 10, 84-200, Wejherowo, Poland.; A Koczwara, Department of Pediatrics and Rheumatology, Specialist Hospital Antoniego Falkiewicza, Warszawska 2, 52-114, Wrocław, Poland.; D Koszałko, Independent Public Health Care, ul. Sukiennicza 13, 64-500, Szamotuły, Poland.; M Kośmider Żurawska, Department of Anaesthesiology and Intensive Therapy, Wrocław Medical University, ul. Borowska 213, 50-556, Wrocław, Poland.; J Książyk, Department of Pediatrics, Nutrition and Metabolic Diseases, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.; B Kucińska, Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Żwirki i Wigury 61, 02-091, Warsaw, Poland.; M Kukawska, Clinical Department of Pediatrics, Mazowiecki Specialist Hospital, ul. Aleksandrowicza 5, Radom, Poland.; A Lackowska, Children's Hospital 'Polanki', Polanki 119, 80-308, Gdańsk, Poland.; K Łapacz, Department of Pediatrics, Children's Hospital, ul. Niekłańska 4/24, 03-924, Warsaw, Poland.; A Maliszak, Pediatric Ward, Regional Specialist Hospital, ul. Iwaszkiewicza 5, 59-220, Legnica, Poland.; A Mania, Department of Infectious Diseases and Child Neurology, Poznań University of Medical Sciences, Szpitalna 27/33; 60-581 Poznań, Poland.; J Mańdziuk, Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland.; A Mazur, Collegium Medicum University of Jan Kochanowski, ul. Grunwaldzka 45, 25-736 Kielce, Poland.; C Niszczota, Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Żwirki i Wigury 61, 02-091, Warsaw, Poland.; P Opalińska Zielonka, Department of Pediatrics, Pediatric Endocrinology and Diabetes, University of Rzeszów, Lwowska 60, 35-301, Rzeszów, Poland.; K Rojewska, Specialist Hospital F. Ceynowy, ul. dr. A. Jagalskiego 10, 84-200, Wejherowo, Poland.; A Rożnowska Wójtowicz, Department of Pediatrics, The Medical Centre of Postgraduate Education, Cegłowska 80, 01-809 Warsaw, Poland.; B Siewert, Department of Preventive Health, Poznań University of Medical Science, Smoluchowskiego 11, 60-179, Poznan, Poland; Infectious Diseases Ward, Greater Poland Children's Health Centre; Wrzoska 1, 60-663, Poznań, Poland.; P Sobiczewska, Multidiscyplinary Hospital in Nowa Sól, ul. Chałubińskiego 1, 67-100, Nowa Sól, Poland.; L Stopyra, Department of Infectious Diseases and Paediatrics, S. Zeromski Hospital in Krakow, Osiedle Na Skarpie 66, 31-913, Kraków, Poland.; A StrobaŻelek, Chair and Department of Environmental Medicine and Epidemiology, Pediatric Ward, City Hospital in Ruda Śla?ska, Medical University of Silesia, ul. Wincentego Lipa 2, 41-703, Ruda Slaska, Poland.; J Stryczyńska Kazubska, Department of Preventive Health, Poznań University of Medical Science, Smoluchowskiego 11, 60-179, Poznan, Poland; Infectious Diseases Ward, Greater Poland Children's Health Centre; Wrzoska 1, 60-663, Poznań, Poland.; T Szatkowski, Collegium Medicum University of Jan Kochanowski, ul. Grunwaldzka 45, 25-736 Kielce, Poland.; B Szczepańska, Collegium Medicum University of Jan Kochanowski, ul. Grunwaldzka 45, 25-736 Kielce, Poland.; M Szczukocki, Collegium Medicum University of Jan Kochanowski, ul. Grunwaldzka 45, 25-736 Kielce, Poland.; R Szylo, Chair and Department of Environmental Medicine and Epidemiology, Pediatric Ward, City Hospital in Ruda Śla?ska, Medical University of Silesia, ul. Wincentego Lipa 2, 41-703, Ruda Slaska, Poland.; F Tyc, Congenital Heart Disease and Pediatric Cardiology Department, Silesian Center for Heart Diseases in Zabrze, ul. Marii Curie Skłodowskiej 9, 41-800, Zabrze, Poland.; K Wielgos, Department of Paediatrics, J. Gromkowski Regional Specialist Hospital in Wrocław, Koszarowa 5, Wrocław, Poland.; E Wołowska, Children's Hospital 'Polanki', Polanki 119, 80-308, Gdańsk, Poland.; J Wysocki, Department of Preventive Health, Poznań University of Medical Science, Smoluchowskiego 11, 60-179, Poznan, Poland; Infectious Diseases Ward, Greater Poland Children's Health Centre; Wrzoska 1, 60-663, Poznań, Poland.; A Zacharzewska, University Clinical Center: Central Teaching Clinical Hospital, ul. Banacha 1A, 02-097, Warsaw, Poland.; M Zaniew, Department of Pediatrics, University of Zielona Góra, Zielona Gora, Poland.; M Zielińska, Department of Anaesthesiology and Intensive Therapy, Wrocław Medical University, ul. Borowska 213, 50-556, Wrocław, Poland.; K Zięba Glonek, District Hospital of the name of Doctor T. Chalubinski in Zakopane, ul. Kamieniec 10, Zakopane.; A Sulik, Department of Pediatric Infectious Diseases, Medical University of Białystok, Waszyngtona 17, 15-274 Białystok, Poland. Keywords: Antibiotics; COVID-19; Multisystem inflammatory syndrome in children |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| SCR Disease Name: | pediatric multisystem inflammatory disease, COVID-19 related |
| تواريخ الأحداث: | Date Created: 20220713 Date Completed: 20220908 Latest Revision: 20230124 |
| رمز التحديث: | 20230126 |
| مُعرف محوري في PubMed: | PMC9271354 |
| DOI: | 10.1016/j.ijid.2022.07.021 |
| PMID: | 35830922 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-3511 |
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| DOI: | 10.1016/j.ijid.2022.07.021 |