دورية أكاديمية
An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics.
| العنوان: | An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics. |
|---|---|
| المؤلفون: | Spick M; Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Lewis HM; Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Frampas CF; Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.; Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Longman K; Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Costa C; Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK.; Surrey Ion Beam Centre, University of Surrey, Guildford, GU2 7XH, UK., Stewart A; Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Dunn-Walters D; Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Greener D; Frimley Park Hospital, Frimley Health NHS Trust, Frimley, GU16 7UJ, UK., Evetts G; Frimley Park Hospital, Frimley Health NHS Trust, Frimley, GU16 7UJ, UK., Wilde MJ; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth, PL4 8AA, UK., Sinclair E; Manchester Institute of Biotechnology, University of Manchester, Manchester, M1 7DN, UK., Barran PE; Manchester Institute of Biotechnology, University of Manchester, Manchester, M1 7DN, UK., Skene DJ; Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Bailey MJ; Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK. m.bailey@surrey.ac.uk.; Surrey Ion Beam Centre, University of Surrey, Guildford, GU2 7XH, UK. m.bailey@surrey.ac.uk. |
| المصدر: | Scientific reports [Sci Rep] 2022 Jul 13; Vol. 12 (1), pp. 11867. Date of Electronic Publication: 2022 Jul 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | COVID-19* , Sebum*/metabolism, Humans ; Lipids/analysis ; Metabolomics ; Saliva/metabolism ; Serum/chemistry |
| مستخلص: | The majority of metabolomics studies to date have utilised blood serum or plasma, biofluids that do not necessarily address the full range of patient pathologies. Here, correlations between serum metabolites, salivary metabolites and sebum lipids are studied for the first time. 83 COVID-19 positive and negative hospitalised participants provided blood serum alongside saliva and sebum samples for analysis by liquid chromatography mass spectrometry. Widespread alterations to serum-sebum lipid relationships were observed in COVID-19 positive participants versus negative controls. There was also a marked correlation between sebum lipids and the immunostimulatory hormone dehydroepiandrosterone sulphate in the COVID-19 positive cohort. The biofluids analysed herein were also compared in terms of their ability to differentiate COVID-19 positive participants from controls; serum performed best by multivariate analysis (sensitivity and specificity of 0.97), with the dominant changes in triglyceride and bile acid levels, concordant with other studies identifying dyslipidemia as a hallmark of COVID-19 infection. Sebum performed well (sensitivity 0.92; specificity 0.84), with saliva performing worst (sensitivity 0.78; specificity 0.83). These findings show that alterations to skin lipid profiles coincide with dyslipidaemia in serum. The work also signposts the potential for integrated biofluid analyses to provide insight into the whole-body atlas of pathophysiological conditions. (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | BB/T002212/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| المشرفين على المادة: | 0 (Lipids) |
| تواريخ الأحداث: | Date Created: 20220713 Date Completed: 20220715 Latest Revision: 20220920 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9278322 |
| DOI: | 10.1038/s41598-022-16123-4 |
| PMID: | 35831456 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-16123-4 |