دورية أكاديمية
أعرض في EDS

Investigating Efficacy of Three DNA-Aptamers in Targeted Plasmid Delivery to Human Prostate Cancer Cell Lines.

التفاصيل البيبلوغرافية
العنوان: Investigating Efficacy of Three DNA-Aptamers in Targeted Plasmid Delivery to Human Prostate Cancer Cell Lines.
المؤلفون: Askarian S; Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 91775-1159, Mashhad, Iran.; Department of Medical Biotechnology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran., Nasab NK; Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 91775-1159, Mashhad, Iran., Aghaee-Bakhtiari SH; Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 91775-1159, Mashhad, Iran., Abadi MHJN; Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 91775-1159, Mashhad, Iran., Oskuee RK; Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 91775-1159, Mashhad, Iran. Oskueekr@mums.ac.ir.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Oskueekr@mums.ac.ir.
المصدر: Molecular biotechnology [Mol Biotechnol] 2023 Jan; Vol. 65 (1), pp. 97-107. Date of Electronic Publication: 2022 Jul 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE
أسماء مطبوعة: Publication: [Cham] : Springer
Original Publication: Totowa, NJ : Humana Press, c1994-
مواضيع طبية MeSH: DNA*/genetics , Prostatic Neoplasms*/genetics, Humans ; Male ; Cell Line ; Plasmids/genetics ; Transfection
مستخلص: Selection of targeted and efficient carriers to deliver drugs and genes to cells and tissues is still a major challenge and to overcome this obstacle, aptamers conjugated to nanoparticles have been broadly examined. To assess whether polycation of aptamers can improve plasmid delivery efficacy, we investigated the effect of three DNA-aptamers (AS1411, WY-5a, and Sgs-8) conjugated to branched polyethylenimine (b-PEI; MW ∼25 kDa) with different combinations of gene (plasmid) for delivery to prostate cancer cell lines (DU145 and PC3). According to transfection assessments, the dual conjugation of aptamers (AS:WY) with b-PEI produced the best results and increased the efficiency of plasmid delivery to up to three folds compared to unmodified PEI. Surprisingly, triple aptamer arrangement not only reduced transfection ability but also showed cytotoxicity. While our results demonstrated potential synergistic effects of AS1411 and WY-5a aptamers for gene delivery, it is important to note that the present evidence relies on the aptamer and cell types.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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معلومات مُعتمدة: Grant No: 951396 Mashhad University of Medical Sciences
فهرسة مساهمة: Keywords: Aptamer; Gene delivery; Non-viral vector; Polyethylenimine; Prostate cancer
المشرفين على المادة: 9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20220714 Date Completed: 20230110 Latest Revision: 20230111
رمز التحديث: 20240628
DOI: 10.1007/s12033-022-00528-7
PMID: 35834121
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0305
DOI:10.1007/s12033-022-00528-7