دورية أكاديمية
أعرض في EDS

Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.

التفاصيل البيبلوغرافية
العنوان: Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.
المؤلفون: Pirozzolo I; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.; Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA., Sepulveda M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Chen L; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Wang Y; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Lei YM; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.; Exelixis, Alameda, California, USA., Li Z; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Li R; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA., Sattar H; Department of Pathology and., Theriault B; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Belkaid Y; National Institutes of Health, Bethesda, Maryland, USA., Chong AS; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Alegre ML; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
المصدر: The Journal of clinical investigation [J Clin Invest] 2022 Sep 01; Vol. 132 (17). Date of Electronic Publication: 2022 Sep 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
مواضيع طبية MeSH: Graft Rejection* , Organ Transplantation*, Animals ; Humans ; Immunity ; Mice ; Skin Transplantation ; Transplantation, Homologous
مستخلص: Solid organ transplantation is the preferred treatment for end-stage organ failure. Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts. Strikingly, barrier organs colonized with microbiota have significantly shorter half-lives than non-barrier transplanted organs, even in immunosuppressed hosts. We previously demonstrated that skin allografts monocolonized with the common human commensal Staphylococcus epidermidis (S.epi) are rejected faster than germ-free (GF) allografts in mice because the presence of S.epi augments the effector alloimmune response locally in the graft. Here, we tested whether host immune responses against graft-resident commensal microbes, including S.epi, can damage colonized grafts independently from the alloresponse. Naive hosts mounted an anticommensal T cell response to colonized, but not GF, syngeneic skin grafts. Whereas naive antigraft commensal T cells modestly damaged colonized syngeneic skin grafts, hosts with prior anticommensal T cell memory mounted a post-transplant immune response against graft-resident commensals that significantly damaged colonized, syngeneic skin grafts. Importantly, allograft recipients harboring this host-versus-commensal immune response resisted immunosuppression. The dual effects of host-versus-commensal and host-versus-allograft responses may partially explain why colonized organs have poorer outcomes than sterile organs in the clinic.
التعليقات: Comment in: Am J Transplant. 2022 Nov;22(11):2495. (PMID: 36346085)
References: Cell Rep. 2019 Dec 3;29(10):2990-2997.e2. (PMID: 31801067)
J Thorac Dis. 2015 Mar;7(3):549-51. (PMID: 25922738)
J Immunol. 2013 Feb 1;190(3):970-6. (PMID: 23255361)
Cell. 2018 Feb 8;172(4):784-796.e18. (PMID: 29358051)
Science. 2019 Jan 18;363(6424):227-228. (PMID: 30655428)
Nature. 1974 Jul 12;250(462):116-29. (PMID: 4152308)
Transplantation. 2017 Oct;101(10):2449-2454. (PMID: 27941430)
Annu Rev Immunol. 2019 Apr 26;37:521-546. (PMID: 30726153)
Am J Kidney Dis. 1996 Aug;28(2):159-72. (PMID: 8768909)
J Immunol. 2009 Dec 15;183(12):7810-6. (PMID: 19923456)
J Immunol. 2019 Nov 1;203(9):2443-2450. (PMID: 31578270)
Curr Opin Immunol. 2019 Aug;59:101-108. (PMID: 31265968)
Nat Commun. 2019 Sep 27;10(1):4401. (PMID: 31562311)
Am J Transplant. 2018 Feb;18(2):289-292. (PMID: 28722285)
Sci Immunol. 2019 Jul 5;4(37):. (PMID: 31278120)
Nat Immunol. 2019 Jun;20(6):756-764. (PMID: 31110315)
Nat Rev Microbiol. 2018 Mar;16(3):143-155. (PMID: 29332945)
Science. 2019 Jan 4;363(6422):. (PMID: 30523076)
Microbiome. 2018 May 25;6(1):96. (PMID: 29793539)
Clin Neuropharmacol. 2010 Mar-Apr;33(2):91-101. (PMID: 20061941)
Sci Immunol. 2019 Mar 8;4(33):. (PMID: 30850393)
Nature. 2009 Jul 2;460(7251):108-12. (PMID: 19543266)
Cell Host Microbe. 2017 Apr 12;21(4):467-477.e5. (PMID: 28343820)
Nature. 1971 Jul 23;232(5308):230-5. (PMID: 4937075)
Nature. 2015 Apr 2;520(7545):104-8. (PMID: 25539086)
JCI Insight. 2019 Jul 16;5:. (PMID: 31310590)
Front Immunol. 2018 Oct 16;9:2394. (PMID: 30386342)
J Clin Invest. 2016 Jul 1;126(7):2736-44. (PMID: 27322054)
Nature. 2013 Aug 8;500(7461):232-6. (PMID: 23842501)
Cell Mol Immunol. 2020 Mar;17(3):237-246. (PMID: 30948792)
J Clin Invest. 2014 Aug;124(8):3579-89. (PMID: 24983319)
Immunity. 2021 Jan 12;54(1):84-98.e5. (PMID: 33212014)
Immunogenetics. 1999 Nov;50(3-4):116-23. (PMID: 10602873)
Immunity. 2015 Nov 17;43(5):1011-21. (PMID: 26588783)
Eur J Immunol. 1993 Dec;23(12):3318-26. (PMID: 8258346)
J Bacteriol. 2018 Apr 9;200(9):. (PMID: 29440258)
Adv Chronic Kidney Dis. 2016 Sep;23(5):281-286. (PMID: 27742381)
J Immunol. 2017 Oct 1;199(7):2451-2459. (PMID: 28855310)
ISME J. 2020 Oct;14(10):2367-2380. (PMID: 32518248)
Nature. 2012 Feb 29;483(7388):227-31. (PMID: 22388819)
معلومات مُعتمدة: P30 DK042086 United States DK NIDDK NIH HHS; R01 AI115716 United States AI NIAID NIH HHS; T32 AI007090 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Adaptive immunity; Immunology; Memory; Transplantation
تواريخ الأحداث: Date Created: 20220714 Date Completed: 20220908 Latest Revision: 20230221
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9435649
DOI: 10.1172/JCI153403
PMID: 35834335
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-8238
DOI:10.1172/JCI153403