دورية أكاديمية
أعرض في EDS

HDL cholesterol levels and susceptibility to COVID-19.

التفاصيل البيبلوغرافية
العنوان: HDL cholesterol levels and susceptibility to COVID-19.
المؤلفون: Chidambaram V; Department of Internal Medicine, University of Arkansas for Medical Sciences, AR, USA., Kumar A; Department of Internal Medicine, University of Arkansas for Medical Sciences, AR, USA., Majella MG; Department of Community Medicine, Sri Venkateshwaraa Medical College Hospital & Research Centre, Pondicherry, India., Seth B; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Sivakumar RK; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China., Voruganti D; Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Bavineni M; Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Baghal A; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Gates K; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Kumari A; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Al'Aref SJ; Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Galiatsatos P; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Karakousis PC; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Mehta JL; Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Division of Cardiovascular Medicine, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. Electronic address: mehtajl@uams.edu.
المصدر: EBioMedicine [EBioMedicine] 2022 Aug; Vol. 82, pp. 104166. Date of Electronic Publication: 2022 Jul 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2014]-
مواضيع طبية MeSH: COVID-19*, Aged ; COVID-19 Testing ; Cholesterol ; Cholesterol, HDL ; Humans ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Triglycerides
مستخلص: Background: Host cell-membrane cholesterol, an important player in viral infections, is in constant interaction with serum high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C). Low serum lipid levels during hospital admission are associated with COVID-19 severity. However, the effect of antecedent serum lipid levels on SARS-CoV-2 infection risk has not been explored.
Methods: From our retrospective cohort from the Arkansas Clinical Data-Repository, we used log-binomial regression to assess the risk of SARS-CoV-2 infection among the trajectories of lipid levels during the 2 years antecedent to COVID-19 testing, identified using group-based-trajectory modelling. We used mixed-effects linear regression to assess the serum lipid level trends followed up to the time of, and 2-months following COVID-19 testing.
Findings: Among the 11001 individuals with a median age of 59 years (IQR 46-70), 1340 (12.2%) tested positive for COVID-19. The highest trajectory for antecedent serum HDL-C was associated with the lowest SARS-CoV-2 infection risk (RR 0.63, 95%CI 0.46-0.86). Antecedent serum LDL-C, total cholesterol (TC), and triglycerides (TG) were not independently associated with SARS-CoV-2 infection risk. In COVID-19 patients, serum HDL-C (-7.7, 95%CI -9.8 to -5.5 mg/dL), and LDL-C (-6.29, 95%CI -12.2 to -0.37 mg/dL), but not TG levels, decreased transiently at the time of testing.
Interpretation: Higher antecedent serum HDL-C, but not LDL-C, TC, or TG, levels were associated with a lower SARS-CoV-2 infection risk. Serum HDL-C, and LDL-C levels declined transiently at the time of infection. Further studies are needed to determine the potential role of lipid-modulating therapies in the prevention and management of COVID-19.
Funding: Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1 TR003107.
Competing Interests: Declaration of interests We declare no conflicts of interest.
(Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: LDL; Risk; SARS-CoV-2; Total cholesterol; Triglycerides
المشرفين على المادة: 0 (Cholesterol, HDL)
0 (Triglycerides)
97C5T2UQ7J (Cholesterol)
تواريخ الأحداث: Date Created: 20220717 Date Completed: 20220816 Latest Revision: 20220816
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9284176
DOI: 10.1016/j.ebiom.2022.104166
PMID: 35843172
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-3964
DOI:10.1016/j.ebiom.2022.104166