دورية أكاديمية
أعرض في EDS

Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

التفاصيل البيبلوغرافية
العنوان: Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.
المؤلفون: Villarreal-Renteria AI; Institute of Research in Biomedical Sciences (IICB), University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico; Translational Nutritional Sciences, University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco México Guadalajara, Mexico. Electronic address: andrea.villarreal@live.com.mx., Herrera-Echauri DD; Department of Public Health, University Center for Health Sciences (CUCS) University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico. Electronic address: dulce.echauri@hotmail.com., Rodríguez-Rocha NP; Translational Nutritional Sciences, University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco México Guadalajara, Mexico; Department of Public Health, University Center for Health Sciences (CUCS) University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico. Electronic address: norma.rodriguez@academicos.udg.mx., Zuñiga LY; Department of Health and Disease, University Center of Tonala (CUT), University of Guadalajara, 555 Nuevo Periferico, ZC 45425 Tonala, Jalisco, Mexico. Electronic address: lauray.zuniga@academicos.udg.mx., Muñoz-Valle JF; Institute of Research in Biomedical Sciences (IICB), University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico; Translational Nutritional Sciences, University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco México Guadalajara, Mexico. Electronic address: drjosefranciscomv@cucs.udg.mx., García-Arellano S; Institute of Research in Biomedical Sciences (IICB), University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico. Electronic address: samuel.garcia4566@academicos.udg.mx., Bernal-Orozco MF; Translational Nutritional Sciences, University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco México Guadalajara, Mexico. Electronic address: fernanda.bernal@academicos.udg.mx., Macedo-Ojeda G; Institute of Research in Biomedical Sciences (IICB), University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico; Translational Nutritional Sciences, University Center for Health Sciences (CUCS), University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco México Guadalajara, Mexico; Department of Public Health, University Center for Health Sciences (CUCS) University of Guadalajara, 950 Sierra Mojada, ZC 44340 Guadalajara, Jalisco, Mexico. Electronic address: gabriela.macedo@cucs.udg.mx.
المصدر: Complementary therapies in medicine [Complement Ther Med] 2022 Nov; Vol. 70, pp. 102852. Date of Electronic Publication: 2022 Jul 14.
نوع المنشور: Journal Article; Meta-Analysis; Review; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Scotland NLM ID: 9308777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6963 (Electronic) Linking ISSN: 09652299 NLM ISO Abbreviation: Complement Ther Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Edinburgh : Elsevier
Original Publication: Edinburgh ; New York : Churchill Livingstone, c1993-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2* , Flax* , Insulin Resistance* , Prediabetic State*, Blood Glucose ; Dietary Supplements ; Glycated Hemoglobin ; Glycemic Control ; Humans ; Insulin ; Randomized Controlled Trials as Topic
مستخلص: Background: Prediabetes and type 2 Diabetes Mellitus (T2DM) are characterized by increased blood sugar concentration and insulin resistance. Although there are only a few reports of potential benefits of flaxseed's consumption on different metabolic parameters, there is no evidence of its effect among people with these conditions.
Objectives: The present systematic review and meta-analysis aimed to assess the effect of flaxseed supplementation on glycemic control variables and insulin resistance in prediabetes and T2DM.
Methods: A literature search was conducted through PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science, to identify Randomized Control Trials (RCTs) that evaluated the effect of milled or ground flaxseed supplementation on fasting blood glucose, HbA1c, insulin concentrations, or HOMA-IR. The data were analyzed using Comprehensive Meta-Analysis (CMA) software version 3.3 in a fixed-effect model.
Results: Seven studies were included in the systematic review and the meta-analysis, the results showed a significant reduction on fasting blood sugar (SMD: -0.392, 95% CI: -0.596, -0.187, p = <0.001, I 2 = 64.81%) insulin concentrations, (SMD: -0.287, 95% CI: -0.534, -0.041, p = 0.022, I 2 = 32.53%), HbA1c (SMD: -0.442, 95% CI: -0.770, -0.114, p = 0.008, I 2 = 11.058%), and HOMA-IR (SMD: -0.284, 95% CI: -0.530, -0.038, p = 0.024, I 2 = 0.00%) after flaxseed supplementation.
Conclusions: Flaxseed supplementation seems to improve glycemic control variables and insulin resistance in prediabetes and T2DM; however, more RCTs are needed to have more decisive evidence about doses, method of supplementation, and the possible effect of synergy with the dietetic treatment.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Blood glucose; Flax; Flaxseed; Glycemic control; HbA1c; Insulin resistance; Linseed; Linum usitatissimum; Prediabetes; Type 2 diabetes mellitus
المشرفين على المادة: 0 (Blood Glucose)
0 (Glycated Hemoglobin A)
0 (Insulin)
تواريخ الأحداث: Date Created: 20220717 Date Completed: 20220830 Latest Revision: 20221207
رمز التحديث: 20221213
DOI: 10.1016/j.ctim.2022.102852
PMID: 35843472
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6963
DOI:10.1016/j.ctim.2022.102852