دورية أكاديمية
Gut Microbiota in Monozygotic Twins Discordant for Parkinson's Disease.
| العنوان: | Gut Microbiota in Monozygotic Twins Discordant for Parkinson's Disease. |
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| المؤلفون: | Bolliri C; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy.; Clinical Nutrition Unit, ASST-Pini-CTO, Milan, Italy., Fontana A; Department for Sustainable Food Process (DiSTAS), Università Cattolica del Sacro Cuore, Cremona, Italy., Cereda E; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Barichella M; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy.; Clinical Nutrition Unit, ASST-Pini-CTO, Milan, Italy., Cilia R; Fondazione IRCCS Istituto Neurologico Carlo Besta, Parkinson and Movement Disorders Unit, Milan, Italy., Ferri V; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy.; Clinical Nutrition Unit, ASST-Pini-CTO, Milan, Italy., Caronni S; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy.; Clinical Nutrition Unit, ASST-Pini-CTO, Milan, Italy., Calandrella D; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy.; Parkinson Institute Milan, ASST-Pini-CTO, Milan, Italy., Morelli L; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy., Pezzoli G; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy.; Parkinson Institute Milan, ASST-Pini-CTO, Milan, Italy. |
| المصدر: | Annals of neurology [Ann Neurol] 2022 Oct; Vol. 92 (4), pp. 631-636. Date of Electronic Publication: 2022 Aug 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: Boston, Little, Brown. |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*/genetics , Parkinson Disease*/genetics , Parkinson Disease*/pathology, Bile Acids and Salts ; Feces ; Humans ; Twins, Monozygotic |
| مستخلص: | Differences in gut microbiota between Parkinson's disease patients and controls seem to depend on multiple-frequently unmeasured-confounders. Monozygotic twins offer a unique model for controlling several factors responsible for interpersonal variation in gut microbiota. Fecal samples from 20 monozygotic twin pairs (n = 40) discordant for Parkinson's disease were studied (metagenomic shotgun analysis). Paired data analysis detected minimal differences in bacterial taxa abundance at species level (Bacteroides pectinophilus [p = 0.037], Bifidobacterium pseudocatenulatum [p = 0.050], and Bifidobacterium catenulatum [p = 0.025]) and in predicted metabolic pathways (primary bile acid biosynthesis [p = 0.037]). Additional studies are warranted to understand the role of gut microbiota in the pathogenesis of Parkinson's disease. ANN NEUROL 2022;92:631-636. (© 2022 American Neurological Association.) |
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| المشرفين على المادة: | 0 (Bile Acids and Salts) |
| تواريخ الأحداث: | Date Created: 20220719 Date Completed: 20220920 Latest Revision: 20221107 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ana.26454 |
| PMID: | 35852145 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-8249 |
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| DOI: | 10.1002/ana.26454 |