دورية أكاديمية
أعرض في EDS

Non-micronized and micronized curcumin do not prevent the behavioral and neurochemical effects induced by acute stress in zebrafish.

التفاصيل البيبلوغرافية
العنوان: Non-micronized and micronized curcumin do not prevent the behavioral and neurochemical effects induced by acute stress in zebrafish.
المؤلفون: Sachett A; Programa de Pós-Graduação Em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Gallas-Lopes M; Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil., Benvenutti R; Programa de Pós-Graduação Em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Marcon M; Departamento de Bioquímica, Farmacologia e Fisiologia, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Linazzi AM; Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil., Aguiar GPS; Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó (Unochapecó), Chapecó, SC, Brazil., Herrmann AP; Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil.; Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Oliveira JV; Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó (Unochapecó), Chapecó, SC, Brazil.; Departamento de Engenharia Química e de Alimentos, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil., Siebel AM; Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó (Unochapecó), Chapecó, SC, Brazil., Piato A; Programa de Pós-Graduação Em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. angelopiato@ufrgs.br.; Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite, 500/305, Porto Alegre, RS, 90050-170, Brazil. angelopiato@ufrgs.br.
المصدر: Pharmacological reports : PR [Pharmacol Rep] 2022 Aug; Vol. 74 (4), pp. 736-744. Date of Electronic Publication: 2022 Jul 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : Cham, Switzerland : Springer International Publishing
Original Publication: Kraków, Poland : Institute of Pharmacology, Polish Academy of Sciences, c2005-
مواضيع طبية MeSH: Curcumin*/pharmacology , Curcumin*/therapeutic use, Animals ; Antioxidants/pharmacology ; Humans ; Oxidative Stress ; Thiobarbituric Acid Reactive Substances ; Zebrafish
مستخلص: Background: Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. (Zingiberaceae), presents neuroprotective properties and can modulate neuronal pathways related to mental disorders. However, curcumin has low bioavailability, which can compromise its use. The micronization process can reduce mean particle diameter and improve this compound's bioavailability and therapeutic potential.
Methods: We compared the behavioral (open tank test, OTT) and neurochemical (thiobarbituric acid reactive substances (TBARS) and non-protein thiols (NPSH) levels) effects of non-micronized curcumin (CUR, 10 mg/kg, ip) and micronized curcumin (MC, 10 mg/kg, ip) in adult zebrafish subjected to a 90-min acute restraint stress (ARS) protocol.
Results: ARS increased the time spent in the central area and the number of crossings and decreased the immobility time of the animals in the OTT. These results suggest an increase in locomotor activity and a decrease in thigmotaxis behavior. Both CUR and MC were not able to prevent these effects. Furthermore, ARS also induced oxidative damage by increasing TBARS and decreasing NPSH levels. Both CUR and MC did not prevent these effects.
Conclusion: ARS-induced behavioral and biochemical effects were not blocked by any curcumin preparation. Therefore, we conclude that curcumin does not have acute anti-stress effects in zebrafish.
(© 2022. The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences.)
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فهرسة مساهمة: Keywords: Acute restraint stress; Curcumin; Open tank test; Oxidative damage; Zebrafish
المشرفين على المادة: 0 (Antioxidants)
0 (Thiobarbituric Acid Reactive Substances)
IT942ZTH98 (Curcumin)
تواريخ الأحداث: Date Created: 20220719 Date Completed: 20220805 Latest Revision: 20220805
رمز التحديث: 20231215
DOI: 10.1007/s43440-022-00389-6
PMID: 35852770
قاعدة البيانات: MEDLINE
الوصف
تدمد:2299-5684
DOI:10.1007/s43440-022-00389-6