دورية أكاديمية
Objective Physical Activity Accumulation and Brain Volume in Older Adults: An MRI and Whole-Brain Volume Study.
| العنوان: | Objective Physical Activity Accumulation and Brain Volume in Older Adults: An MRI and Whole-Brain Volume Study. |
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| المؤلفون: | Melo Neves L; Post-Graduate Program in Health Sciences, Santo Amaro University, UNISA, São Paulo, Brazil.; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., Ritti-Dias R; Universidade Nove de Julho, São Paulo, Brazil., Juday V; Anhembi Morumbi University, UAM, São Paulo, Brazil., Marquesini R; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil., Mendes Gerage A; Federal University of Santa Catarina, UFSC, Florianópolis, Brazil., Cândido Laurentino G; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.; São Judas University, São Paulo, Brazil., Hoffmann Nunes R; Dasa Laboratório, São Paulo, Brazil.; Faculty of Medical Science, Santa Casa de São Paulo, São Paulo, Brazil., Stubbs B; Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Ugrinowitsch C; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil. |
| المصدر: | The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2023 Jun 01; Vol. 78 (6), pp. 902-910. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press Original Publication: Washington, DC : Gerontological Society of America, c1995- |
| مواضيع طبية MeSH: | Exercise* , Brain*/diagnostic imaging , Brain*/pathology, Humans ; Aged ; Magnetic Resonance Imaging ; Atrophy ; Accelerometry |
| مستخلص: | A decrease in brain volume (ie, brain atrophy) is a marker of cognitive health in older adults. Insufficient weekly accumulation of moderate and vigorous physical activity (MVPA) has been associated with lower brain volume. As this association has been established for a small number of brain areas and structures and atrophy rates seem to be nonuniform between them, more comprehensive analyses are warranted. We compared the volume of 71 brain areas and structures in 45 older adults who met and did not meet objectively measured MVPA recommendations. In addition, we used multiple regression models to determine whether cardiorespiratory fitness (VO2PEAK), MVPA, and health-related risk factors could affect the atrophy of brain areas and structures. An accelerometer (GT9-X ActiGraph) was worn for 7 days. Participants were then classified into 2 groups: <150 minutes MVPA (<150'MVPA; n = 20) and ≥150 minutes MVPA (≥150'MVPA; n = 25) per week. Older adults who accumulated ≥150'MVPA per week had significantly higher absolute and relative (% of intracranial volume) volumes of 39 and 9 brain areas and structures, respectively, than those who accumulated <150'MVPA per week. Higher VO2PEAK seems to be a key predictor of the atrophy of brain areas and structures. In conclusion, meeting weekly physical activity recommendations seems to have a widespread effect on preserving the volume of more than 30 brain areas and structures in older adults. VO2PEAK seems to be the most frequent and important predictor of brain volume preservation. (© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | ICA-CL-2017-03-001 United Kingdom DH_ Department of Health; United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Brain aging; Cognition; Exercise; Human aging |
| تواريخ الأحداث: | Date Created: 20220720 Date Completed: 20230605 Latest Revision: 20230613 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1093/gerona/glac150 |
| PMID: | 35857361 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-535X |
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| DOI: | 10.1093/gerona/glac150 |