دورية أكاديمية
أعرض في EDS

Trends in COVID-19 patient characteristics in a large electronic health record database in the United States: A cohort study.

التفاصيل البيبلوغرافية
العنوان: Trends in COVID-19 patient characteristics in a large electronic health record database in the United States: A cohort study.
المؤلفون: Liang C; Optum Epidemiology, Boston, MA, United States of America., Ogilvie RP; Optum Epidemiology, Boston, MA, United States of America., Doherty M; Optum Epidemiology, Boston, MA, United States of America., Clifford CR; Optum Epidemiology, Boston, MA, United States of America., Chomistek AK; Optum Epidemiology, Boston, MA, United States of America., Gately R; Optum Epidemiology, Boston, MA, United States of America., Song J; Optum Epidemiology, Boston, MA, United States of America., Enger C; Optum Epidemiology, Boston, MA, United States of America., Seeger J; Optum Epidemiology, Boston, MA, United States of America., Lin ND; IQVIA, King of Prussia, PA, United States of America., Wang FT; Optum Epidemiology, Boston, MA, United States of America.
المصدر: PloS one [PLoS One] 2022 Jul 20; Vol. 17 (7), pp. e0271501. Date of Electronic Publication: 2022 Jul 20 (Print Publication: 2022).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: COVID-19*/epidemiology , COVID-19*/therapy, Cohort Studies ; Electronic Health Records ; Hospitalization ; Humans ; Male ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; United States/epidemiology
مستخلص: Background: Electronic health record (EHR) databases provide an opportunity to facilitate characterization and trends in patients with COVID-19.
Methods: Patients with COVID-19 were identified based on an ICD-10 diagnosis code for COVID-19 (U07.1) and/or a positive SARS-CoV-2 viral lab result from January 2020 to November 2020. Patients were characterized in terms of demographics, healthcare utilization, clinical comorbidities, therapies, laboratory results, and procedures/care received, including critical care, intubation/ventilation, and occurrence of death were described, overall and by month.
Results: There were 393,773 patients with COVID-19 and 56,996 with a COVID-19 associated hospitalization. A greater percentage of patients hospitalized with COVID-19 relative to all COVID-19 cases were older, male, African American, and lived in the Northeast and South. The most common comorbidities before admission/infection date were hypertension (40.8%), diabetes (29.5%), and obesity (23.8%), and the most common diagnoses during hospitalization were pneumonia (59.6%), acute respiratory failure (44.8%), and dyspnea (28.0%). A total of 85.7% of patients hospitalized with COVID-19 had CRP values > 10 mg/L, 75.5% had fibrinogen values > 400 mg/dL, and 76.8% had D-dimer values > 250 ng/mL. Median values for platelets, CRP, lactate dehydrogenase, D-dimer, and fibrinogen tended to decrease from January-March to November. The use of chloroquine/hydroxychloroquine during hospitalization peaked by March (71.2%) and was used rarely by May (5.1%) and less than 1% afterwards, while the use of remdesivir had increased by May (10.0%) followed by dexamethasone by June (27.7%). All-cause mortality was 3.2% overall and 15.0% among those hospitalized; 21.0% received critical care and 16.0% received intubation/ventilation/ECMO.
Conclusions: This study characterizes US patients with COVID-19 and their management during hospitalization over the first eleven months of this disease pandemic.
Competing Interests: All coauthors are current or former employees of Optum and may own stock in UnitedHealth Group. Nancy Lin is currently an employee of IQVIA. Caihua Liang is currently an employee of Pfizer. This does not alter our adherence to PLOS ONE policies on sharing data and materials
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تواريخ الأحداث: Date Created: 20220720 Date Completed: 20220722 Latest Revision: 20220728
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9299343
DOI: 10.1371/journal.pone.0271501
PMID: 35857793
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0271501