دورية أكاديمية
أعرض في EDS

Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration.

التفاصيل البيبلوغرافية
العنوان: Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration.
المؤلفون: Cadiz Diaz A; Department of Biology, University of Miami, Coral Gables, FL 33146., Schmidt NA; Department of Biology, University of Miami, Coral Gables, FL 33146., Yamazaki M; Department of Regenerative Biology and Medicine, MDI Biological Laboratory, Bar Harbor, ME 04672., Hsieh CJ; Department of Biology, University of Miami, Coral Gables, FL 33146., Lisse TS; Department of Biology, University of Miami, Coral Gables, FL 33146.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL 33136., Rieger S; Department of Biology, University of Miami, Coral Gables, FL 33146.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL 33136.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 26; Vol. 119 (30), pp. e2115009119. Date of Electronic Publication: 2022 Jul 19.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Axons*/physiology , Hydrogen Peroxide*/metabolism , NADPH Oxidases*/genetics , NADPH Oxidases*/physiology , Nerve Regeneration*/genetics , Wound Healing*/genetics , Wound Healing*/physiology , Zebrafish Proteins*/genetics , Zebrafish Proteins*/physiology, Animals ; Keratinocytes/physiology ; Sensory Receptor Cells/physiology ; Zebrafish
مستخلص: Tissue wounding induces cutaneous sensory axon regeneration via hydrogen peroxide (H 2 O 2 ) that is produced by the epithelial NADPH oxidase, Duox1. Sciatic nerve injury instead induces axon regeneration through neuronal uptake of the NADPH oxidase, Nox2, from macrophages. We therefore reasoned that the tissue environment in which axons are damaged stimulates distinct regenerative mechanisms. Here, we show that cutaneous axon regeneration induced by tissue wounding depends on both neuronal and keratinocyte-specific mechanisms involving H 2 O 2 signaling. Genetic depletion of H 2 O 2 in sensory neurons abolishes axon regeneration, whereas keratinocyte-specific H 2 O 2 depletion promotes axonal repulsion, a phenotype mirrored in duox1 mutants. Intriguingly, cyba mutants, deficient in the essential Nox subunit, p22Phox, retain limited axon regenerative capacity but display delayed Wallerian degeneration and axonal fusion, observed so far only in invertebrates. We further show that keratinocyte-specific oxidation of the epidermal growth factor receptor (EGFR) at a conserved cysteine thiol (C797) serves as an attractive cue for regenerating axons, leading to EGFR-dependent localized epidermal matrix remodeling via the matrix-metalloproteinase, MMP-13. Therefore, wound-induced cutaneous axon de- and regeneration depend on the coordinated functions of NADPH oxidases mediating distinct processes following injury.
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معلومات مُعتمدة: P20 GM103423 United States GM NIGMS NIH HHS; P20 GM104318 United States GM NIGMS NIH HHS; R01 CA215973 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: EGFR; Wallerian degeneration; axon fusion; axon regeneration; hydrogen peroxide
المشرفين على المادة: 0 (Zebrafish Proteins)
0 (duox protein, zebrafish)
BBX060AN9V (Hydrogen Peroxide)
EC 1.6.3.- (NADPH Oxidases)
تواريخ الأحداث: Date Created: 20220720 Date Completed: 20220722 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC9340058
DOI: 10.1073/pnas.2115009119
PMID: 35858442
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.2115009119