دورية أكاديمية
Activity of Delafloxacin and Levofloxacin against Stenotrophomonas maltophilia at Simulated Plasma and Intrapulmonary pH Values.
العنوان: | Activity of Delafloxacin and Levofloxacin against Stenotrophomonas maltophilia at Simulated Plasma and Intrapulmonary pH Values. |
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المؤلفون: | Vialichka A; College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA., Biagi M; College of Pharmacy, University of Illinois Chicago, Rockford, Illinois, USA., Meyer K; College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA., Wu T; College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA., Shajee A; College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA., Tan X; College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA., Wenzler E; College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA. |
المصدر: | Microbiology spectrum [Microbiol Spectr] 2022 Aug 31; Vol. 10 (4), pp. e0270521. Date of Electronic Publication: 2022 Jul 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : ASM Press, 2013- |
مواضيع طبية MeSH: | Gram-Negative Bacterial Infections* , Stenotrophomonas maltophilia*, Anti-Bacterial Agents/pharmacology ; Fluoroquinolones/pharmacology ; Humans ; Hydrogen-Ion Concentration ; Levofloxacin/pharmacology ; Microbial Sensitivity Tests |
مستخلص: | Fluoroquinolones have become a popular treatment option for Stenotrophomonas maltophilia infections. Although levofloxacin is most commonly used, delafloxacin demonstrates comparable in vitro activity when evaluated under standard susceptibility testing conditions at neutral pH. At acidic pH, the activity of the anionic delafloxacin is improved, while the activity of the zwitterionic levofloxacin is reduced. Because the human respiratory tract has a pH of ~6.6 and is the most common site of S. maltophilia infection, it is vital to understand the activity of these agents in this environment. Therefore, levofloxacin and delafloxacin were tested against clinical S. maltophilia isolates via broth microdilution testing ( n = 37) and time-kill analysis ( n = 5) in neutral cation-adjusted Mueller-Hinton broth (CAMHB) (pH 7.3) and acidic CAMHB (aCAMHB) (pH 6.5). In CAMHB, MIC |
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فهرسة مساهمة: | Keywords: Stenotrophomonas maltophilia; acidic environment; delafloxacin; epithelial lining fluid; fluoroquinolone; levofloxacin; pH; pharmacodynamics; pneumonia; susceptibility testing; time-kill assay |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Fluoroquinolones) 6315412YVF (delafloxacin) 6GNT3Y5LMF (Levofloxacin) |
تواريخ الأحداث: | Date Created: 20220721 Date Completed: 20220908 Latest Revision: 20231020 |
رمز التحديث: | 20231020 |
مُعرف محوري في PubMed: | PMC9431699 |
DOI: | 10.1128/spectrum.02705-21 |
PMID: | 35862943 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2165-0497 |
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DOI: | 10.1128/spectrum.02705-21 |