دورية أكاديمية
Sex-specific Regulation of Prolactin Secretion by Pituitary Bradykinin Receptors.
| العنوان: | Sex-specific Regulation of Prolactin Secretion by Pituitary Bradykinin Receptors. |
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| المؤلفون: | Abeledo-Machado A; Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Peña-Zanoni M; Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Bornancini D; Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Camilletti MA; Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Faraoni EY; Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Marcial A; Laboratorio de Endocrinología Molecular de la Reproducción, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Rulli S; Laboratorio de Endocrinología Molecular de la Reproducción, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Alhenc-Gelas F; INSERM U1138, Universite Paris-Cite, Sorbonne Universite, Centre de Recherche des Cordeliers, Paris, France., Díaz-Torga GS; Laboratorio de Fisio-Patología Hormonal, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina. |
| المصدر: | Endocrinology [Endocrinology] 2022 Sep 01; Vol. 163 (9). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
| مواضيع طبية MeSH: | Pituitary Neoplasms*/genetics , Pituitary Neoplasms*/metabolism , Prolactinoma*/genetics , Prolactinoma*/metabolism, Animals ; Female ; Humans ; Kinins ; Male ; Mice ; Prolactin/metabolism ; Receptor, Bradykinin B2/agonists ; Receptor, Bradykinin B2/genetics ; Receptor, Bradykinin B2/metabolism ; Receptors, Bradykinin |
| مستخلص: | Sex differences in the control of prolactin secretion are well documented. Sex-related differences in intrapituitary factors regulating lactotroph function have recently attracted attention. Sex differences in prolactinoma development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for poorly understood reasons. Kallikrein, the enzyme releasing kinins has been found in the pituitary, but there is no information on pituitary kinin receptors and their function. In the present work, we characterized pituitary bradykinin receptors (BRs) at the messenger RNA and protein levels in 2 mouse models of prolactinoma, Drd2 receptor gene inactivation and hCGβ gene overexpression, in both males and females, wild type or genomically altered. BR B2 (B2R) accounted for 97% or more of total pituitary BRs in both models, regardless of genotype, and was present in lactotrophs, somatotrophs, and gonadotrophs. Male pituitaries displayed higher level of B2R than females, regardless of genotype. Pituitary B2R gene expression was downregulated by estrogen in both males and females but only in females by dopamine. Activation of B1R or B2R by selective pharmacological agonists induced prolactin release in male pituitaries but inhibited prolactin secretion in female pituitaries. Increased B2R content was observed in pituitaries of mutated animals developing prolactinomas, compared to their respective wild-type controls. The present study documents a novel sex-related difference in the control of prolactin secretion and suggests that kinins are involved, through B2R activation, in lactotroph function and prolactinoma development. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: bradykinin receptor; kinin; lactotrophs; prolactin; prolactinoma; sex differences |
| المشرفين على المادة: | 0 (Kinins) 0 (Receptor, Bradykinin B2) 0 (Receptors, Bradykinin) 9002-62-4 (Prolactin) |
| تواريخ الأحداث: | Date Created: 20220721 Date Completed: 20220728 Latest Revision: 20220907 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1210/endocr/bqac108 |
| PMID: | 35863039 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7170 |
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| DOI: | 10.1210/endocr/bqac108 |