تقرير
Mesenchymal Stromal Cell Secretome for Therapeutic Application in Skin Wound Healing: A Systematic Review of Preclinical Studies.
| العنوان: | Mesenchymal Stromal Cell Secretome for Therapeutic Application in Skin Wound Healing: A Systematic Review of Preclinical Studies. |
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| المؤلفون: | Marques da Silva M; Department of Cell Biology, Embryology, and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil., Olsson DC; Department of Veterinary Medicine, Federal Institute of Santa Catarina, Florianópolis, Brazil., Teixeira BL; Department of Cell Biology, Embryology, and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil., Jeremias TDS; Department of Cell Biology, Embryology, and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil., Trentin AG; Department of Cell Biology, Embryology, and Genetics, Federal University of Santa Catarina, Florianópolis, Brazil.; National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil. |
| المصدر: | Cells, tissues, organs [Cells Tissues Organs] 2023; Vol. 212 (6), pp. 567-582. Date of Electronic Publication: 2022 Jul 22. |
| نوع المنشور: | Systematic Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 100883360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1422-6421 (Electronic) Linking ISSN: 14226405 NLM ISO Abbreviation: Cells Tissues Organs Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, c1999- |
| مواضيع طبية MeSH: | Mesenchymal Stem Cells* , Mesenchymal Stem Cell Transplantation*/methods, Rats ; Mice ; Animals ; Endothelial Cells ; Secretome ; Skin/injuries ; Wound Healing ; Collagen |
| مستخلص: | Non-healing skin wounds remain a challenge in the healthcare system. In this sense, it is suggested that the secretome of mesenchymal stromal cells (MSCs) can be effective as a therapeutic strategy for regenerative medicine. Therefore, this systematic review aimed to determine the effects of treatment with a secretome derived from MSCs on the healing of skin wounds in a preclinical model of rodents (mice and rats). Studies were systematically retrieved from 6 databases and gray literature that provided 1,172 records, of which 25 met the inclusion criteria for qualitative analysis. Results revealed substantial heterogeneity among studies concerning experimental designs and methodologies, resulting in a high risk of bias. Together, the selected studies reported that treatment improved wound healing by (1) accelerating wound closure and improving skin repair quality; (2) reducing inflammation by decreasing the number of cells and inflammatory cytokines, accompanied by polarization of the M2 macrophage; (3) complete re-epithelialization and epidermal reorganization; (4) neovascularization promoted by proliferation of endothelial cells (CD34+) and increased levels of pro-angiogenic mediators; (5) better scar quality promoted by increased expression of collagen types I and III, as well as improved deposition and remodeling of collagen fibers. In conclusion, despite the need for alignment of methodological protocols and transparent reports in future studies, results show that the secretome of MSCs from different tissue sources corresponds to a promising tool of regenerative medicine for the treatment of skin wounds. (© 2022 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Animal studies; Conditioned media; Mesenchymal stem cells; Secretory vesicles; Wound healing |
| المشرفين على المادة: | 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20220724 Date Completed: 20231216 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| DOI: | 10.1159/000526093 |
| PMID: | 35871510 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-6421 |
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| DOI: | 10.1159/000526093 |