دورية أكاديمية
Keratinocytes secrete multiple inflammatory and immune biomarkers, which are regulated by LL-37, in a psoriasis mimicking microenvironment.
العنوان: | Keratinocytes secrete multiple inflammatory and immune biomarkers, which are regulated by LL-37, in a psoriasis mimicking microenvironment. |
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المؤلفون: | Sigurgrimsdottir H; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Department of Immunology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland., Bjornsdottir EO; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Department of Immunology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland., Eysteinsdottir JH; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Department of Immunology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland., Olafsson JH; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Sigurgeirsson B; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Agnarsson BA; Department of Pathology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland., Einarsdottir HK; Department of Immunology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland., Freysdottir J; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Department of Immunology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland., Ludviksson BR; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Department of Immunology, Landspitali-the National University Hospital of Iceland, Reykjavík, Iceland. |
المصدر: | Scandinavian journal of immunology [Scand J Immunol] 2021 Dec; Vol. 94 (6), pp. e13096. Date of Electronic Publication: 2021 Oct 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0323767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3083 (Electronic) Linking ISSN: 03009475 NLM ISO Abbreviation: Scand J Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Oxford : Blackwell Scientific Publications Original Publication: Oslo, Universitetsforlaget. |
مواضيع طبية MeSH: | Psoriasis* , Vascular Endothelial Growth Factor A*/metabolism, Biomarkers/metabolism ; Chemokines/metabolism ; Humans ; Keratinocytes/metabolism ; Skin/pathology |
مستخلص: | Psoriasis is an autoimmune disease driven by a Th17 response linked to the antimicrobial peptide (AMP) LL-37 that has been connected to the induction and chronicity of psoriasis. We show that keratinocytes secrete various immune biomarkers with a direct link to psoriasis immunopathogenesis. Under pro-inflammatory microenvironmental conditions, LL-37 was found to regulate keratinocyte secretion of various immune biomarkers (eg C-X-C motif chemokine ligand (CXCL)8 and interleukin (IL)-1β) and alter extracellular signal-regulated kinase (ERK)1/2 signalling. However, during neutral conditions LL-37 induced a different pattern of keratinocyte immune biomarker secretion (eg vascular endothelial growth factor, CXCL8 and IL-6). Thus, an interesting pattern emerged regarding the immunomodulatory effects of LL-37 on keratinocytes; in general, expression of immune biomarkers that were upregulated in a Th1-like microenvironment was downregulated in the presence of LL-37. In contrast, LL-37 reinforced the Th17 response. In active psoriatic skin lesions, LL-37 expression was found to be significantly upregulated, which was also evident from the unique diffuse epidermic expression pattern not found in healthy skin. Finally, successful phototherapy of psoriasis patients converted this LL-37 inflammatory psoriatic skin pattern into a more localized basal layer expression as found in healthy controls. Thus, these findings demonstrate that LL-37 has a significant role in skin immune homeostasis and that its interplay with keratinocytes may have a more direct role in the immunopathogenesis of psoriasis than previously thought. (© 2021 The Scandinavian Foundation for Immunology.) |
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معلومات مُعتمدة: | Icelandic Research Fund; Landspitali University Hospital Research Fund |
فهرسة مساهمة: | Keywords: keratinocytes; psoriasis and antimicrobial peptides |
المشرفين على المادة: | 0 (Biomarkers) 0 (Chemokines) 0 (Vascular Endothelial Growth Factor A) |
تواريخ الأحداث: | Date Created: 20220725 Date Completed: 20220726 Latest Revision: 20220726 |
رمز التحديث: | 20221213 |
DOI: | 10.1111/sji.13096 |
PMID: | 35872634 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-3083 |
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DOI: | 10.1111/sji.13096 |