دورية أكاديمية
Inter-Individual Variability in Lipid Response: A Narrative Review.
| العنوان: | Inter-Individual Variability in Lipid Response: A Narrative Review. |
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| المؤلفون: | Patnaik S; Northwestern University Feinberg School of Medicine, Chicago, Ill., Pollevick ME; Northwestern University Feinberg School of Medicine, Chicago, Ill., Lara-Breitinger KM; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minn., Stone NJ; Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Medicine (Cardiology) and Preventive Medicine, Vascular Center of the Bluhm Cardiovascular Institute of Northwestern Memorial Hospital, Chicago, Ill. Electronic address: nstoneMD1@gmail.com. |
| المصدر: | The American journal of medicine [Am J Med] 2022 Dec; Vol. 135 (12), pp. 1427-1433.e7. Date of Electronic Publication: 2022 Jul 22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0267200 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-7162 (Electronic) Linking ISSN: 00029343 NLM ISO Abbreviation: Am J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Excerpta Medica Original Publication: New York, Donnelly. |
| مواضيع طبية MeSH: | Anticholesteremic Agents*/therapeutic use , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use, Humans ; Cholesterol, LDL ; Ezetimibe/pharmacology ; Hypolipidemic Agents/therapeutic use ; Proprotein Convertase 9 |
| مستخلص: | Lipid-lowering guidelines emphasize shared decision-making between clinicians and patients, resulting in patients anticipating the degree of response from diet or drug therapy. Challenging for physicians is understanding the sources of variability complicating their management decisions, which include non-adherence, genetic considerations, additional lipid parameters including lipoprotein (a) levels, and rare systemic responses limiting benefits that result in non-responsiveness to monoclonal antibody injection. In this narrative review, we focus on the variability of low-density lipoprotein cholesterol (LDL-C) response to guideline-directed interventions such as statins, ezetimibe, bile acid sequestrants, fibrates, proprotein/convertase subtilisin-kexin type 9 inhibitors, and LDL-C-lowering diets. We hypothesize that the variability in individual lipid responses is multifactorial. We provide an illustrative model with a check list that can be used to identify factors that may be present in the individual patient. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diet; Dose–response; Ezetemibe; Fibrates; Hyperlipidemia; LDL-C; Lipid-lowering therapy; Low-density lipoprotein cholesterol; PCSK9 inhibitors; Statins; Variability |
| المشرفين على المادة: | 0 (Cholesterol, LDL) 0 (Anticholesteremic Agents) EOR26LQQ24 (Ezetimibe) 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 0 (Hypolipidemic Agents) EC 3.4.21.- (Proprotein Convertase 9) |
| تواريخ الأحداث: | Date Created: 20220725 Date Completed: 20221122 Latest Revision: 20221122 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.amjmed.2022.06.018 |
| PMID: | 35878687 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1555-7162 |
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| DOI: | 10.1016/j.amjmed.2022.06.018 |