دورية أكاديمية
أعرض في EDS

An Insulin Receptor-Binding Multifunctional Protein from Tamarindus indica L. Presents a Hypoglycemic Effect in a Diet-Induced Type 2 Diabetes-Preclinical Study.

التفاصيل البيبلوغرافية
العنوان: An Insulin Receptor-Binding Multifunctional Protein from Tamarindus indica L. Presents a Hypoglycemic Effect in a Diet-Induced Type 2 Diabetes-Preclinical Study.
المؤلفون: Costa I; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil., Lima M; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil., Medeiros A; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil., Bezerra L; Chemistry Postgraduate Program, Science Center, Federal University of Ceará, Fortaleza 60020-903, Brazil., Santos P; Federal Institute of Education, Science and Technology of Rio Grande do Norte, Macau 59500-000, Brazil., Serquiz A; Nutrition Course, University Center of Rio Grande do Norte, Natal 59014-545, Brazil., Lima M; Veterinary Medicine Course, Potiguar University, Natal 59056-000, Brazil., Oliveira G; Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil., Santos E; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil.; Biochemistry Department, Biosciences Center, Federal University of Rio Grande, Natal 59075-000, Brazil.; Tropical Medicine Institute, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil., Maciel B; Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil.; Nutrition Department, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil., Monteiro N; Chemistry Postgraduate Program, Science Center, Federal University of Ceará, Fortaleza 60020-903, Brazil.; Analytical Chemistry and Physical Chemistry Department, Science Center, Federal University of Ceará, Fortaleza 60020-903, Brazil., Morais AH; Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil.; Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil.; Nutrition Department, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59075-000, Brazil.
المصدر: Foods (Basel, Switzerland) [Foods] 2022 Jul 25; Vol. 11 (15). Date of Electronic Publication: 2022 Jul 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101670569 Publication Model: Electronic Cited Medium: Print ISSN: 2304-8158 (Print) Linking ISSN: 23048158 NLM ISO Abbreviation: Foods Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: The objectives of this study were to evaluate the hypoglycemic effect of the trypsin inhibitor isolated from tamarind seeds (TTI) in an experimental model of T2DM and the in silico interaction between the conformational models of TTI 56/287 and the insulin receptor (IR). After inducing T2DM, 15 male Wistar rats were randomly allocated in three groups ( n = 5): 1-T2DM group without treatment; 2-T2DM group treated with adequate diet; and 3-T2DM treated with TTI (25 mg/kg), for 10 days. Insulinemia and fasting glucose were analyzed, and the HOMA-IR and HOMA-β were calculated. The group of animals treated with TTI presented both lower fasting glucose concentrations ( p = 0.0031) and lower HOMA-IR indexes ( p = 0.0432), along with higher HOMA-β indexes ( p = 0.0052), than the animals in the other groups. The in silico analyses showed that there was an interaction between TTIp 56/287 and IR with interaction potential energy (IPE) of -1591.54 kJ mol -1 (±234.90), being lower than that presented by insulin and IR: -894.98 kJ mol -1 (±32.16). In addition, the presence of amino acids, type of binding and place of interaction other than insulin were identified. This study revealed the hypoglycemic effect of a bioactive molecule of protein origin from Tamarind seeds in a preclinical model of T2DM. Furthermore, the in silico analysis allowed the prediction of its binding in the IR, raising a new perspective for explaining TTI's action on the glycemic response.
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معلومات مُعتمدة: 426116/2018-6 National Council for Scientific and Technological Development; 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: hypoglycemic agent; molecular docking simulation; plant proteins; tamarind; trypsin inhibitor
تواريخ الأحداث: Date Created: 20220727 Latest Revision: 20220731
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9332146
DOI: 10.3390/foods11152207
PMID: 35892791
قاعدة البيانات: MEDLINE
الوصف
تدمد:2304-8158
DOI:10.3390/foods11152207