دورية أكاديمية
The Role of PIM Kinases in Pediatric Solid Tumors.
| العنوان: | The Role of PIM Kinases in Pediatric Solid Tumors. |
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| المؤلفون: | Julson JR; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Marayati R; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Beierle EA; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Stafman LL; Division of Pediatric Surgery, Department of Surgery, Vanderbilt University, Nashville, TN 37240, USA. |
| المصدر: | Cancers [Cancers (Basel)] 2022 Jul 22; Vol. 14 (15). Date of Electronic Publication: 2022 Jul 22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مستخلص: | PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials. |
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| معلومات مُعتمدة: | T32 CA229102 United States CA NCI NIH HHS; CA229102 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: PIM kinase; hepatoblastoma; neuroblastoma; osteosarcoma; pediatric |
| تواريخ الأحداث: | Date Created: 20220727 Latest Revision: 20230825 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9332273 |
| DOI: | 10.3390/cancers14153565 |
| PMID: | 35892829 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2072-6694 |
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| DOI: | 10.3390/cancers14153565 |