دورية أكاديمية
أعرض في EDS

Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect.

التفاصيل البيبلوغرافية
العنوان: Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect.
المؤلفون: Shehata TM; Food and Security in Saudi Arabia, Scientific Research, Graduate Studies and Scientific Research, King Faisal University, Alhofuf 36362, Al-Ahsa, Saudi Arabia.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Alhofuf 31982, Al-Ahsa, Saudi Arabia.; Department of Pharmaceutics, College of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Almostafa MM; Food and Security in Saudi Arabia, Scientific Research, Graduate Studies and Scientific Research, King Faisal University, Alhofuf 36362, Al-Ahsa, Saudi Arabia.; Department of Chemistry, College of Science, King Faisal University, Alhofuf 31982, Al-Ahsa, Saudi Arabia., Elsewedy HS; Food and Security in Saudi Arabia, Scientific Research, Graduate Studies and Scientific Research, King Faisal University, Alhofuf 36362, Al-Ahsa, Saudi Arabia.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Alhofuf 31982, Al-Ahsa, Saudi Arabia.
المصدر: Polymers [Polymers (Basel)] 2022 Jul 26; Vol. 14 (15). Date of Electronic Publication: 2022 Jul 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101545357 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4360 (Electronic) Linking ISSN: 20734360 NLM ISO Abbreviation: Polymers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Diabetes mellitus (DM) is a metabolic disorder associated with an increased blood glucose level. The world health burden of DM has increased as a result of numerous causes that necessitates suitable treatment. Pioglitazone (PGZ) is a generally prescribed medication for managing type II diabetes. However, its low solubility creates complications for its formulation. Therefore, the aim of the current study was to incorporate PGZ into a nanoemulsion (NE) formulation prepared with Nigella sativa oil (NSO) to boost the action of PGZ. To our knowledge, no previous study has addressed the combination and synergistic effect of PGZ and NSO as a hypoglycemic NE formulation intended for oral administration. An experiment was designed to test several PGZ-loaded NE formulations, varying factors such as NSO, surfactant and co-surfactant concentrations. These factors were investigated for their influence on responses including particle size and in vitro release. An optimized PGZ-loaded NE was selected and examined for its morphology, kinetic activity and stability. Further, the anti-diabetic effect of the optimized formulation was evaluated using diabetically induced rats. The optimized formula exhibited a good particle size of 167.1 nm and in vitro release of 89.5%. A kinetic study revealed that the drug release followed the Korsmeyer-Peppas mechanism. Additionally, the PGZ-loaded NE formulation was found to be stable, showing non-significant variation in the evaluated parameters when stored at 4 and 25 °C for a period of 3 months. In vivo investigation of the PGZ-loaded NE formulation showed a significant reduction in blood glucose level, which appeared to be enhanced by the presence of NSO. In conclusion, NS-NE could be a promising nanocarrier for enhancing the hypoglycemic effect of PGZ.
References: Artif Cells Nanomed Biotechnol. 2015;43(5):334-44. (PMID: 24641773)
RSC Adv. 2020 Dec 9;10(71):43894-43903. (PMID: 35519703)
3 Biotech. 2015 Apr;5(2):123-127. (PMID: 28324579)
Molecules. 2021 Jun 07;26(11):. (PMID: 34200144)
Polymers (Basel). 2021 Feb 14;13(4):. (PMID: 33672981)
Gels. 2022 Apr 15;8(4):. (PMID: 35448146)
Drug Deliv Transl Res. 2015 Feb;5(1):51-62. (PMID: 25787339)
Iran J Pharm Res. 2017 Winter;16(Suppl):2-23. (PMID: 29844772)
Indian J Pharm Sci. 2009 Mar;71(2):139-42. (PMID: 20336212)
Gels. 2022 Apr 22;8(5):. (PMID: 35621560)
Colloids Surf B Biointerfaces. 2021 Sep;205:111868. (PMID: 34034223)
J Endocrinol Invest. 2014 Nov;37(11):1031-40. (PMID: 25125023)
Gels. 2021 Dec 25;8(1):. (PMID: 35049551)
Cardiovasc Endocrinol. 2017 Feb 15;6(1):8-16. (PMID: 31646113)
Drug Deliv Transl Res. 2021 Apr;11(2):471-497. (PMID: 33528830)
J Pharm Anal. 2018 Feb;8(1):45-54. (PMID: 29568667)
Pharmaceutics. 2020 Mar 12;12(3):. (PMID: 32178278)
Pak J Pharm Sci. 2020 Nov;33(6(Supplementary)):2847-2857. (PMID: 33879446)
J Pharmacol Exp Ther. 2001 Sep;298(3):865-72. (PMID: 11504778)
Int J Nanomedicine. 2017 Oct 05;12:7291-7309. (PMID: 29042776)
AAPS PharmSciTech. 2014 Aug;15(4):822-33. (PMID: 24687241)
Gels. 2021 Nov 18;7(4):. (PMID: 34842709)
Pharmaceutics. 2022 Feb 16;14(2):. (PMID: 35214157)
Expert Opin Pharmacother. 2006 Mar;7(4):463-76. (PMID: 16503818)
Int J Mol Sci. 2012 Oct 11;13(10):13049-64. (PMID: 23202937)
Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:245-253. (PMID: 30184748)
Nanomaterials (Basel). 2017 Jul 22;7(7):. (PMID: 28737673)
Molecules. 2019 Nov 20;24(23):. (PMID: 31756981)
Plants (Basel). 2021 Apr 09;10(4):. (PMID: 33918742)
Pharmaceutics. 2021 Jan 28;13(2):. (PMID: 33525642)
Asian J Pharm Sci. 2021 Jan;16(1):62-76. (PMID: 33613730)
Drug Dev Ind Pharm. 2019 Dec;45(12):1907-1914. (PMID: 31621436)
Evid Based Complement Alternat Med. 2019 May 12;2019:1528635. (PMID: 31214267)
Clin Exp Pharmacol Physiol. 2021 Nov;48(11):1445-1453. (PMID: 34297870)
Pharmaceutics. 2019 Jun 11;11(6):. (PMID: 31212607)
Int J Mol Sci. 2020 Mar 06;21(5):. (PMID: 32155866)
معلومات مُعتمدة: Grant No., CHAIR47. the Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia [Grant No. CHAIR47]. The APC was funded by the sam
فهرسة مساهمة: Keywords: Nigella sativa; diabetes; hypoglycemia; nanoemulsion; optimization; pioglitazone
تواريخ الأحداث: Date Created: 20220727 Latest Revision: 20220731
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9332742
DOI: 10.3390/polym14153021
PMID: 35893989
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4360
DOI:10.3390/polym14153021