دورية أكاديمية
Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect.
العنوان: | Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect. |
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المؤلفون: | Shehata TM; Food and Security in Saudi Arabia, Scientific Research, Graduate Studies and Scientific Research, King Faisal University, Alhofuf 36362, Al-Ahsa, Saudi Arabia.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Alhofuf 31982, Al-Ahsa, Saudi Arabia.; Department of Pharmaceutics, College of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Almostafa MM; Food and Security in Saudi Arabia, Scientific Research, Graduate Studies and Scientific Research, King Faisal University, Alhofuf 36362, Al-Ahsa, Saudi Arabia.; Department of Chemistry, College of Science, King Faisal University, Alhofuf 31982, Al-Ahsa, Saudi Arabia., Elsewedy HS; Food and Security in Saudi Arabia, Scientific Research, Graduate Studies and Scientific Research, King Faisal University, Alhofuf 36362, Al-Ahsa, Saudi Arabia.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Alhofuf 31982, Al-Ahsa, Saudi Arabia. |
المصدر: | Polymers [Polymers (Basel)] 2022 Jul 26; Vol. 14 (15). Date of Electronic Publication: 2022 Jul 26. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101545357 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4360 (Electronic) Linking ISSN: 20734360 NLM ISO Abbreviation: Polymers (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : MDPI |
مستخلص: | Diabetes mellitus (DM) is a metabolic disorder associated with an increased blood glucose level. The world health burden of DM has increased as a result of numerous causes that necessitates suitable treatment. Pioglitazone (PGZ) is a generally prescribed medication for managing type II diabetes. However, its low solubility creates complications for its formulation. Therefore, the aim of the current study was to incorporate PGZ into a nanoemulsion (NE) formulation prepared with Nigella sativa oil (NSO) to boost the action of PGZ. To our knowledge, no previous study has addressed the combination and synergistic effect of PGZ and NSO as a hypoglycemic NE formulation intended for oral administration. An experiment was designed to test several PGZ-loaded NE formulations, varying factors such as NSO, surfactant and co-surfactant concentrations. These factors were investigated for their influence on responses including particle size and in vitro release. An optimized PGZ-loaded NE was selected and examined for its morphology, kinetic activity and stability. Further, the anti-diabetic effect of the optimized formulation was evaluated using diabetically induced rats. The optimized formula exhibited a good particle size of 167.1 nm and in vitro release of 89.5%. A kinetic study revealed that the drug release followed the Korsmeyer-Peppas mechanism. Additionally, the PGZ-loaded NE formulation was found to be stable, showing non-significant variation in the evaluated parameters when stored at 4 and 25 °C for a period of 3 months. In vivo investigation of the PGZ-loaded NE formulation showed a significant reduction in blood glucose level, which appeared to be enhanced by the presence of NSO. In conclusion, NS-NE could be a promising nanocarrier for enhancing the hypoglycemic effect of PGZ. |
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معلومات مُعتمدة: | Grant No., CHAIR47. the Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia [Grant No. CHAIR47]. The APC was funded by the sam |
فهرسة مساهمة: | Keywords: Nigella sativa; diabetes; hypoglycemia; nanoemulsion; optimization; pioglitazone |
تواريخ الأحداث: | Date Created: 20220727 Latest Revision: 20220731 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9332742 |
DOI: | 10.3390/polym14153021 |
PMID: | 35893989 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2073-4360 |
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DOI: | 10.3390/polym14153021 |