دورية أكاديمية
أعرض في EDS

Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation.

التفاصيل البيبلوغرافية
العنوان: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation.
المؤلفون: Croft CA; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France., Thaller A; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France., Marie S; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France., Doisne JM; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France., Surace L; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France., Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, UMR 1163, Paris, France.; Imagine Institute, Université Paris Cité, Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France., Bustamante J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, UMR 1163, Paris, France.; Imagine Institute, Université Paris Cité, Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, UMR 1163, Paris, France.; Imagine Institute, Université Paris Cité, Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France.; Howard Hughes Medical Institute, New York, NY, USA., Di Santo JP; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France. james.di-santo@pasteur.fr.
المصدر: Nature communications [Nat Commun] 2022 Jul 27; Vol. 13 (1), pp. 4344. Date of Electronic Publication: 2022 Jul 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Immunity, Innate* , Lymphocytes*, Cell Differentiation ; Humans ; Interleukin-23 ; Killer Cells, Natural ; Lymphoid Progenitor Cells/physiology ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Receptors, Notch/metabolism
مستخلص: Innate lymphoid cells (ILCs) include cytotoxic natural killer cells and distinct groups of cytokine-producing innate helper cells which participate in immune defense and promote tissue homeostasis. Circulating human ILC precursors (ILCP) able to generate all canonical ILC subsets via multi-potent or uni-potent intermediates according to our previous work. Here we show potential cooperative roles for the Notch and IL-23 signaling pathways for human ILC differentiation from blood ILCP using single cell cloning analyses and validate these findings in patient samples with rare genetic deficiencies in IL12RB1 and RORC. Mechanistically, Notch signaling promotes upregulation of the transcription factor RORC, enabling acquisition of Group 1 (IFN-γ) and Group 3 (IL-17A, IL-22) effector functions in multi-potent and uni-potent ILCP. Interfering with RORC or signaling through its target IL-23R compromises ILC3 effector functions but also generally suppresses ILC production from multi-potent ILCP. Our results identify a Notch->RORC- > IL-23R pathway which operates during human ILC differentiation. These observations may help guide protocols to expand functional ILC subsets in vitro with an aim towards novel ILC therapies for human disease.
(© 2022. The Author(s).)
References: J Exp Med. 2011 Oct 24;208(11):2321-33. (PMID: 22006976)
Immunol Cell Biol. 2019 Apr;97(4):360-367. (PMID: 30264912)
Immunity. 2018 Sep 18;49(3):464-476.e4. (PMID: 30193847)
Cell Rep. 2016 Jul 12;16(2):392-404. (PMID: 27346359)
J Immunol. 2016 Jun 1;196(11):4731-8. (PMID: 27183613)
Curr Opin Microbiol. 2021 Oct;63:83-91. (PMID: 34274597)
Inflamm Cell Signal. 2016;3(3):. (PMID: 28286805)
Cell. 2012 Oct 12;151(2):289-303. (PMID: 23021777)
Nature. 2010 Apr 29;464(7293):1367-70. (PMID: 20200518)
Nat Immunol. 2013 Mar;14(3):221-9. (PMID: 23334791)
Medicine (Baltimore). 2010 Nov;89(6):381-402. (PMID: 21057261)
Front Immunol. 2020 Mar 12;11:348. (PMID: 32226427)
Nat Immunol. 2021 Oct;22(10):1210-1217. (PMID: 34545250)
Nat Immunol. 2011 Sep 11;12(11):1055-62. (PMID: 21909091)
Nat Rev Immunol. 2013 Feb;13(2):145-9. (PMID: 23348417)
Cell. 2018 Aug 23;174(5):1054-1066. (PMID: 30142344)
Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):143-51. (PMID: 24265932)
Cell. 2017 Mar 9;168(6):1086-1100.e10. (PMID: 28283063)
J Exp Med. 2007 Nov 26;204(12):2925-34. (PMID: 17998388)
Immunity. 2018 Jun 19;48(6):1091-1103. (PMID: 29924975)
ACS Chem Biol. 2012 Apr 20;7(4):672-7. (PMID: 22292739)
Nat Med. 2016 Mar;22(3):319-23. (PMID: 26878233)
J Exp Med. 2019 Aug 5;216(8):1762-1776. (PMID: 31201208)
Semin Immunol. 2014 Dec;26(6):454-70. (PMID: 25453225)
Immunity. 2000 Nov;13(5):715-25. (PMID: 11114383)
J Clin Invest. 2020 Jun 1;130(6):3158-3171. (PMID: 32163377)
Eur J Immunol. 2021 Jul;51(7):1792-1798. (PMID: 33728641)
J Histochem Cytochem. 2004 Apr;52(4):509-16. (PMID: 15034002)
J Immunol. 2013 Jan 15;190(2):521-5. (PMID: 23255360)
J Exp Med. 2016 Jul 25;213(8):1589-608. (PMID: 27401342)
Front Immunol. 2019 Dec 13;10:2895. (PMID: 31921156)
J Exp Med. 2016 Apr 4;213(4):569-83. (PMID: 26976630)
J Exp Med. 2008 Jul 7;205(7):1543-50. (PMID: 18591412)
Biomed J. 2021 Apr;44(2):133-143. (PMID: 33863682)
Eur J Immunol. 2019 Jan;49(1):11-18. (PMID: 30350853)
Cytokine Growth Factor Rev. 2019 Feb;45:1-8. (PMID: 30563755)
Nature. 2010 Jan 28;463(7280):540-4. (PMID: 20023630)
J Immunol. 2016 Feb 1;196(3):1070-80. (PMID: 26712946)
Nat Immunol. 2012 Jan 22;13(3):229-36. (PMID: 22267218)
Sci Immunol. 2018 Dec 21;3(30):. (PMID: 30578351)
Science. 2015 Aug 7;349(6248):606-613. (PMID: 26160376)
Immunity. 2017 Nov 21;47(5):820-833. (PMID: 29166586)
Front Cell Dev Biol. 2016 Jan 13;3:85. (PMID: 26793707)
Sci Signal. 2016 May 03;9(426):ra45. (PMID: 27141929)
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11489-94. (PMID: 20534524)
Curr Opin Immunol. 2016 Feb;38:75-85. (PMID: 26707651)
Front Immunol. 2017 Apr 18;8:419. (PMID: 28458667)
Immunity. 2016 May 17;44(5):1140-50. (PMID: 27178467)
Front Immunol. 2012 Apr 09;3:72. (PMID: 22566953)
Immunity. 2013 Jul 25;39(1):148-59. (PMID: 23890069)
Nat Immunol. 2004 Jan;5(1):64-73. (PMID: 14691482)
Hum Mutat. 2013 Oct;34(10):1329-39. (PMID: 23864330)
Science. 1998 May 29;280(5368):1432-5. (PMID: 9603732)
Immunity. 2013 Apr 18;38(4):769-81. (PMID: 23453631)
Immunity. 2017 Jan 17;46(1):148-161. (PMID: 27986455)
Immunity. 2014 Dec 18;41(6):988-1000. (PMID: 25500367)
Immunity. 2018 Nov 20;49(5):915-928.e5. (PMID: 30446384)
Immunity. 2008 Dec 19;29(6):958-70. (PMID: 19084435)
Cell Res. 2021 May;31(5):554-568. (PMID: 33420427)
Neurosci Lett. 2013 Apr 29;541:161-6. (PMID: 23466692)
Turk J Pediatr. 2016;58(3):331-336. (PMID: 28266204)
J Immunol. 2017 Oct 15;199(8):2777-2793. (PMID: 28893953)
J Immunol. 2009 Jun 15;182(12):7381-8. (PMID: 19494260)
Immunity. 1997 Oct;7(4):493-504. (PMID: 9354470)
J Immunol. 2020 Nov 15;205(10):2679-2693. (PMID: 33020148)
Nat Immunol. 2009 Jan;10(1):66-74. (PMID: 19029905)
Cell. 2006 Sep 22;126(6):1121-33. (PMID: 16990136)
معلومات مُعتمدة: R01 AI095983 United States AI NIAID NIH HHS; United States HHMI Howard Hughes Medical Institute
المشرفين على المادة: 0 (Interleukin-23)
0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
0 (RORC protein, human)
0 (Receptors, Notch)
تواريخ الأحداث: Date Created: 20220727 Date Completed: 20220729 Latest Revision: 20230317
رمز التحديث: 20230320
مُعرف محوري في PubMed: PMC9329340
DOI: 10.1038/s41467-022-32089-3
PMID: 35896601
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-32089-3