دورية أكاديمية

Different effects for different questions: An illustration using short cervix and the risk of preterm birth.

التفاصيل البيبلوغرافية
العنوان: Different effects for different questions: An illustration using short cervix and the risk of preterm birth.
المؤلفون: Ross RK; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Cole SR; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Westreich D; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Edwards JK; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Musonda P; Department of Epidemiology and Biostatistics, School of Public Health, University of Zambia, Lusaka, Zambia., Vwalika B; Department of Obstetrics and Gynecology, School of Medicine, University of Zambia, Lusaka, Zambia., Kasaro MP; University of North Carolina Global Projects Zambia, Lusaka, Zambia., Price JT; Department of Obstetrics and Gynecology, School of Medicine, University of Zambia, Lusaka, Zambia.; University of North Carolina Global Projects Zambia, Lusaka, Zambia.; Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Stringer JSA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
المصدر: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2023 Mar; Vol. 160 (3), pp. 842-849. Date of Electronic Publication: 2022 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3479 (Electronic) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : Malden, MA : Wiley
Original Publication: [New York, NY] Hoeber Medical Division, Harper & Row, [c1969-
مواضيع طبية MeSH: Premature Birth*/epidemiology , Premature Birth*/etiology, Female ; Pregnancy ; Infant, Newborn ; Humans ; Cervix Uteri/diagnostic imaging ; Prospective Studies ; Cervical Length Measurement ; Zambia/epidemiology
مستخلص: Objective: To illustrate the difference between exposure effects and population attributable effects.
Methods: We examined the effect of mid-pregnancy short cervical length (<25 mm) on preterm birth using data from a prospective cohort of pregnant women in Lusaka, Zambia. Preterm birth was live birth or stillbirth before 37 weeks of pregnancy. For estimation, we used multivariable regression and parametric g-computation.
Results: Among 1409 women included in the analysis, short cervix was rare (2.4%); 13.6% of births were preterm. Exposure effect estimates were large (marginal risk ratio 2.86, 95% confidence interval [CI] 1.80-4.54), indicating that the preterm birth risk was substantially higher among women with a short cervix compared with women without a short cervix. However, the population attributable effect estimates were close to the null (risk ratio 1.06, 95% CI 1.02-1.10), indicating that an intervention to counteract the impact of short cervix on preterm birth would have minimal effect on the population risk of preterm birth.
Conclusion: Although authors often refer to "the" effect, there are actually different types of effects, as we have illustrated here. In planning research, it is important to consider which effect to estimate to ensure that the estimate aligns with the research objective.
(© 2022 International Federation of Gynecology and Obstetrics.)
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معلومات مُعتمدة: K01 TW010857 United States TW FIC NIH HHS; R01 AI157758 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: exposure effect; population attributable effect; preterm birth; short cervix
تواريخ الأحداث: Date Created: 20220728 Date Completed: 20230214 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC11155393
DOI: 10.1002/ijgo.14372
PMID: 35899762
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3479
DOI:10.1002/ijgo.14372