New quantification method for monitoring 18 l-amino acids levels in schizophrenic patients by high-performance liquid chromatography coupled to tandem quadrupole mass spectrometer.

التفاصيل البيبلوغرافية
العنوان:	New quantification method for monitoring 18 l-amino acids levels in schizophrenic patients by high-performance liquid chromatography coupled to tandem quadrupole mass spectrometer.
المؤلفون:	Kaddah MMY; Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications, New Borg El-Arab, Alexandria, Egypt., Ali HM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Hammad SF; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt., El-Malla SF; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
المصدر:	Biomedical chromatography : BMC [Biomed Chromatogr] 2022 Nov; Vol. 36 (11), pp. e5472. Date of Electronic Publication: 2022 Aug 09.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE
أسماء مطبوعة:	Publication: 1990- : Chichester : Wiley Original Publication: London : Heyden & Son, c1986-1990
مواضيع طبية MeSH:	Schizophrenia* , Tandem Mass Spectrometry*/methods, Amines ; Amino Acids ; Chromatography, High Pressure Liquid/methods ; Formates ; Humans ; Methanol ; Water
مستخلص:	A fast, uncomplicated, sensitive and fully validated high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method has been developed for estimating l-amino acids in the plasma of schizophrenic patients. The gradient-elution chromatographic method was implemented with the Luna® PFP column (50 × 2.0 mm, 5 μm), and a mobile phase of 0.1% formic acid in water and methanol was used. The intra- and interday variability of the l-amino acids was <13.11%, their accuracy ranged from 85.14 to 116.75% at the quality control levels and the lower limit of quantification ranged from 2.5 to 15 nm. The extraction efficiency (apparent recovery) of amino acids from healthy plasma was employed by spiking the plasma with standard amino acids at the quality control levels. Their percentage recoveries ranged from 80.4 to 119.94%. Our method has a short run time and fast sample preparation compared with existing methods, which suffer from long preparative steps and/or time-consuming analysis, restricted reagents and the suboptimal performance characteristics of presently available technologies. Therefore, the proposed HPLC-MS/MS method was effectively applied for monitoring the l-amino acids in the plasma of schizophrenic patients and healthy volunteers. (© 2022 John Wiley & Sons Ltd.)
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فهرسة مساهمة:	Keywords: amino acids; liquid chromatography-tandem mass spectrometry; metabolic disorders; schizophrenia
المشرفين على المادة:	0 (Amines) 0 (Amino Acids) 0 (Formates) 059QF0KO0R (Water) Y4S76JWI15 (Methanol)
تواريخ الأحداث:	Date Created: 20220730 Date Completed: 20221004 Latest Revision: 20221004
رمز التحديث:	20221213
DOI:	10.1002/bmc.5472
PMID:	35906747
قاعدة البيانات:	MEDLINE

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تدمد:	1099-0801
DOI:	10.1002/bmc.5472