دورية أكاديمية
The epitranscriptome in ageing and stress resistance: A systematic review.
| العنوان: | The epitranscriptome in ageing and stress resistance: A systematic review. |
|---|---|
| المؤلفون: | Wagner A; Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria., Schosserer M; Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria; Institute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria. Electronic address: markus.schosserer@meduniwien.ac.at. |
| المصدر: | Ageing research reviews [Ageing Res Rev] 2022 Nov; Vol. 81, pp. 101700. Date of Electronic Publication: 2022 Jul 28. |
| نوع المنشور: | Journal Article; Review; Systematic Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | MicroRNAs* , Saccharomyces cerevisiae*/genetics, Aging/genetics ; AlkB Homolog 8, tRNA Methyltransferase ; Animals ; Humans ; Methyltransferases/genetics ; Methyltransferases/metabolism ; RNA, Messenger/genetics ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism |
| مستخلص: | Modifications of RNA, collectively called the "epitranscriptome", might provide novel biomarkers and innovative targets for interventions in geroscience but are just beginning to be studied in the context of ageing and stress resistance. RNA modifications modulate gene expression by affecting translation initiation and speed, miRNA binding, RNA stability, and RNA degradation. Nonetheless, the precise underlying molecular mechanisms and physiological consequences of most alterations of the epitranscriptome are still only poorly understood. We here systematically review different types of modifications of rRNA, tRNA and mRNA, the methodology to analyze them, current challenges in the field, and human disease associations. Furthermore, we compiled evidence for a connection between individual enzymes, which install RNA modifications, and lifespan in yeast, worm and fly. We also included resistance to different stressors and competitive fitness as search criteria for genes potentially relevant to ageing. Promising candidates identified by this approach include RCM1/NSUN5, RRP8, and F33A8.4/ZCCHC4 that introduce base methylations in rRNA, the methyltransferases DNMT2 and TRM9/ALKBH8, as well as factors involved in the thiolation or A to I editing in tRNA, and finally the m 6 A machinery for mRNA. Competing Interests: Competing interests The authors have no competing interests to declare. (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Ageing; Caenorhabditis elegans; Drosophila melanogaster; Epitranscriptome; Geroscience; Lifespan; RNA modification; Saccharomyces cerevisiae |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (RNA, Messenger) 0 (RNA, Ribosomal) 9014-25-9 (RNA, Transfer) EC 1.14.11.- (ALKBH8 protein, human) EC 1.14.11.- (AlkB Homolog 8, tRNA Methyltransferase) EC 2.1.1.- (Methyltransferases) |
| تواريخ الأحداث: | Date Created: 20220731 Date Completed: 20221018 Latest Revision: 20230130 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.arr.2022.101700 |
| PMID: | 35908668 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1872-9649 |
|---|---|
| DOI: | 10.1016/j.arr.2022.101700 |