دورية أكاديمية
أعرض في EDS

Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds.

التفاصيل البيبلوغرافية
العنوان: Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds.
المؤلفون: Cristina-Silva C; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., Amaral-Silva L; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., Santos KM; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., Correa GM; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., da Silva WC; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., Fernandes MHMR; Department of Animal Science, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., da Silva GSF; Institute of Biological Sciences, Department of Physiology and Biophysics, Federal University of Minas Gerais (ICB/UFMG), Belo Horizonte, Brazil., Gargaglioni LH; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil., Almeida MC; Center for Natural and Human Sciences, Federal University of ABC (UFABC), São Bernardo do Campo, Brazil., Bicego KC; Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, Sao Paulo State University, Jaboticabal, Brazil.
المصدر: Frontiers in physiology [Front Physiol] 2022 Jul 15; Vol. 13, pp. 892828. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Transient receptor potential vanilloid 4 (TRPV4) channels are sensitive to warm ambient temperatures (T a s), triggering heat loss responses in adult rats in a T a s range of ∼26-30°C. In birds, however, the thermoregulatory role of TRPV4 has never been shown. Here, we hypothesized that stimulation of TRPV4 induces thermolytic responses for body temperature (T b ) maintenance in birds, and that this function is already present in early life, when the T a range for TRPV4 activation does not represent a warm condition for these animals. We first demonstrated the presence of TRPV4 in the dorsal and ventral skin of chickens ( Gallus gallus domesticus ) by immunohistochemistry. Then, we evaluated the effects of the TRPV4 agonist, RN1747, and the TRPV4 antagonists, HC067047 and GSK2193874, on T b and thermoeffectors at different T a s in 5-day-old chicks and 60-day-old adult chickens. For the chicks, RN1747 transiently reduced T b both in thermoneutrality (31°C) and in a cold T a for this phase (26°C), which relied on huddling behavior inhibition. The TRPV4 antagonists alone did not affect T b or thermoeffectors but blocked the T b decrease and huddling inhibition promoted by RN1747. For the adults, TRPV4 antagonism increased T b when animals were exposed to 28°C (suprathermoneutral condition for adults), but not to 19°C. In contrast, RN1747 decreased T b by reducing metabolic rate and activating thermal tachypnea at 19°C, a T a below the activation range of TRPV4. Our results indicate that peripheral TRPV4 receptors are functional in early life, but may be inhibited at that time when the range of activation (∼26-30°C) represents cold T a for chicks, and become physiologically relevant for T b maintenance when the activation T a range for TRPV4 becomes suprathermoneutral for adult chickens.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Cristina-Silva, Amaral-Silva, Santos, Correa, da Silva, Fernandes, da Silva, Gargaglioni, Almeida and Bicego.)
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فهرسة مساهمة: Keywords: Metabolism; body temperature; chicken; huddling; peripheral thermoreceptor; thermolysis; thermoregulation
تواريخ الأحداث: Date Created: 20220801 Latest Revision: 20220802
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9337882
DOI: 10.3389/fphys.2022.892828
PMID: 35910562
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2022.892828