دورية أكاديمية
أعرض في EDS

Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials.

التفاصيل البيبلوغرافية
العنوان: Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials.
المؤلفون: McKenna MC; Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Room 5.43, Pearse Street, Dublin 2, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland., Lope J; Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Room 5.43, Pearse Street, Dublin 2, Ireland., Tan EL; Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Room 5.43, Pearse Street, Dublin 2, Ireland., Bede P; Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, Room 5.43, Pearse Street, Dublin 2, Ireland. bedep@tcd.ie.; Department of Neurology, St James's Hospital, Dublin, Ireland. bedep@tcd.ie.
المصدر: Brain imaging and behavior [Brain Imaging Behav] 2022 Dec; Vol. 16 (6), pp. 2755-2767. Date of Electronic Publication: 2022 Aug 03.
نوع المنشور: Systematic Review; Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Secaucus, NJ : Springer
مواضيع طبية MeSH: Frontotemporal Dementia*/diagnostic imaging , Frontotemporal Dementia*/genetics, Humans ; Magnetic Resonance Imaging/methods ; Mutation ; tau Proteins/metabolism ; Progranulins/genetics ; Progranulins/metabolism ; Gray Matter/diagnostic imaging ; Gray Matter/metabolism
مستخلص: Computational imaging and quantitative biomarkers offer invaluable insights in the pre-symptomatic phase of neurodegenerative conditions several years before clinical manifestation. In recent years, there has been a focused effort to characterize pre-symptomatic cerebral changes in familial frontotemporal dementias using computational imaging. Accordingly, a systematic literature review was conducted of original articles investigating pre-symptomatic imaging changes in frontotemporal dementia focusing on study design, imaging modalities, data interpretation, control cohorts and key findings. The review is limited to the most common genotypes: chromosome 9 open reading frame 72 (C9orf72), progranulin (GRN), or microtubule-associated protein tau (MAPT) genotypes. Sixty-eight studies were identified with a median sample size of 15 (3-141) per genotype. Only a minority of studies were longitudinal (28%; 19/68) with a median follow-up of 2 (1-8) years. MRI (97%; 66/68) was the most common imaging modality, and primarily grey matter analyses were conducted (75%; 19/68). Some studies used multimodal analyses 44% (30/68). Genotype-associated imaging signatures are presented, innovative study designs are highlighted, common methodological shortcomings are discussed and lessons for future studies are outlined. Emerging academic observations have potential clinical implications for expediting the diagnosis, tracking disease progression and optimising the timing of pharmaceutical trials.
(© 2022. The Author(s).)
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معلومات مُعتمدة: HRB EIA-2017-019 Ireland Health Research Board; JPND-Cofund-2-2019-1 Ireland Health Research Board
فهرسة مساهمة: Keywords: Biomarker; Frontotemporal dementia; MRI; Neuroimaging; Pre-symptomatic; Prodromal
المشرفين على المادة: 0 (tau Proteins)
0 (Progranulins)
تواريخ الأحداث: Date Created: 20220803 Date Completed: 20221202 Latest Revision: 20221203
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9712335
DOI: 10.1007/s11682-022-00711-z
PMID: 35920960
قاعدة البيانات: MEDLINE
الوصف
تدمد:1931-7565
DOI:10.1007/s11682-022-00711-z