دورية أكاديمية
أعرض في EDS

Cooled and traditional thermal radiofrequency ablation of genicular nerves in patients with chronic knee pain: a comparative outcomes analysis.

التفاصيل البيبلوغرافية
العنوان: Cooled and traditional thermal radiofrequency ablation of genicular nerves in patients with chronic knee pain: a comparative outcomes analysis.
المؤلفون: Wu BP; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA wup@ccf.org., Grits D; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA., Foorsov V; Department of Orthopedic Surgery/Regional Medical Group, Northwestern Medicine, Chicago, Illinois, USA., Xu J; Department of Pain Management, Cleveland Clinic, Cleveland, Ohio, USA., Tankha P; Center for Comprehensive Pain Recovery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA., Bolash RB; Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
المصدر: Regional anesthesia and pain medicine [Reg Anesth Pain Med] 2022 Aug 03. Date of Electronic Publication: 2022 Aug 03.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 9804508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8651 (Electronic) Linking ISSN: 10987339 NLM ISO Abbreviation: Reg Anesth Pain Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : [London, United Kingdom] : BMJ
Original Publication: Secaucus, NJ : Churchill Livingstone, c1998-
مستخلص: Introduction: Genicular nerve radiofrequency ablation (GNRFA) is a minimally invasive intervention for patients with chronic knee pain (CKP) not responding to conservative treatments. Few investigations have compared treatment outcomes of cooled-RFA (c-RFA) and thermal-RFA (t-RFA), two common approaches of GNRFA. This study aims to investigate and compare outcomes, including probability of treatment success, between c-RFA and t-RFA in patients with CKP.
Methods: This retrospective cohort study analyzed a total of 208 propensity score matched patients, including 104 patients who received c-RFA and 104 patients who received t-RFA. The primary outcome was probability of pain relief after the procedure, defined as reduction in Numeric Rating Scale (NRS) pain score of 2 or greater. The secondary outcomes were degree of NRS pain score reductions, duration of relief, and the probability of patients receiving TKA within 1 year of treatment.
Results: T-RFA was associated with a higher probability of pain relief within 1, 3, and 6 months after procedure when compared with c-RFA. Probabilities of pain relief from t-RFA and c-RFA were 62% (95% CI 51% to 71%) and 43% (95% CI 34% to 53%; p=0.01) within 1 month, 78% (95% CI 68% to 85%) and 55% (95% CI 45% to 64%; p<0.001) within 3 months, and 79% (95% CI 70% to 86%) and 59% (95% CI 49% to 68%; p<0.01) within 6 months, respectively. t-RFA was also associated with greater mean NRS pain score reduction at 1 month after procedure: -4.71 (95% CI -5.3 to -4.1) when compared with -3.59 (95% CI -4.3 to -2.9; p=0.02) from c-RFA. T-RFA and c-RFA were comparable in pain score reduction at 3, 6, 9 and 12 months after procedure. Both groups demonstrated comparable duration of relief and probability of patients receiving TKA within 1 year.
Discussion: Both t-RFA and c-RFA effectively reduced NRS pain scores in most patients with CKP within the 1 year follow-up period. Genicular nerve t-RFA was associated with a higher probability of treatment success and a greater degree of pain relief at 1 month after the procedure when compared with c-RFA in propensity score matched patients with CKP.
Competing Interests: Competing interests: The authors have no conflict of interest related to this manuscript. JX is a consultant for Genentech. RBB is a consultant for Medtronic, Agnovos, and Pfizer.
(© American Society of Regional Anesthesia & Pain Medicine 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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معلومات مُعتمدة: K08 CA228039 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: chronic pain; lower extremity; outcomes; pain management; technology
تواريخ الأحداث: Date Created: 20220803 Latest Revision: 20240216
رمز التحديث: 20240217
مُعرف محوري في PubMed: PMC9895122
DOI: 10.1136/rapm-2022-103693
PMID: 35922077
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8651
DOI:10.1136/rapm-2022-103693