دورية أكاديمية
أعرض في EDS

Mammography screening is associated with more favourable breast cancer tumour characteristics and better overall survival: case-only analysis of 3739 Asian breast cancer patients.

التفاصيل البيبلوغرافية
العنوان: Mammography screening is associated with more favourable breast cancer tumour characteristics and better overall survival: case-only analysis of 3739 Asian breast cancer patients.
المؤلفون: Lim ZL; Genome Institute of Singapore, Laboratory of Women's Health & Genetics, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore., Ho PJ; Genome Institute of Singapore, Laboratory of Women's Health & Genetics, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore., Khng AJ; Genome Institute of Singapore, Laboratory of Women's Health & Genetics, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore., Yeoh YS; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Ong ATW; Department of Surgery, National University Hospital, Singapore, 119054, Singapore., Tan BKT; Department of General Surgery, Sengkang General Hospital, Singapore, 544886, Singapore.; Department of Breast Surgery, Singapore General Hospital, Singapore, 168753, Singapore.; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore., Tan EY; Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, 308232, Singapore., Tan SM; Division of Breast Surgery, Changi General Hospital, Singapore, 529889, Singapore., Lim GH; Breast Department, KK Women's and Children's Hospital, Singapore, 229899, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore., Lee JA; Duke-NUS Medical School, Singapore, 169857, Singapore., Tan VK; Department of Breast Surgery, Singapore General Hospital, Singapore, 168753, Singapore.; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore., Hu J; Department of General Surgery, Ng Teng Fong General Hospital, Singapore, 609606, Singapore., Li J; Genome Institute of Singapore, Laboratory of Women's Health & Genetics, 60 Biopolis Street, Genome, #02-01, Singapore, 138672, Singapore. lijm1@gis.a-star.edu.sg.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. lijm1@gis.a-star.edu.sg., Hartman M; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.; Department of Surgery, National University Hospital, Singapore, 119054, Singapore.
المصدر: BMC medicine [BMC Med] 2022 Aug 04; Vol. 20 (1), pp. 239. Date of Electronic Publication: 2022 Aug 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مواضيع طبية MeSH: Breast Neoplasms*/diagnostic imaging , Early Detection of Cancer*, Cohort Studies ; Female ; Humans ; Mammography ; Mass Screening
مستخلص: Background: Early detection of breast cancer (BC) through mammography screening (MAM) is known to reduce mortality. We examined the differential effect that mammography has on BC characteristics and overall survival and the sociodemographic determinants of MAM utilization in a multi-ethnic Asian population.
Methods: This study included 3739 BC patients from the Singapore Breast Cancer Cohort (2010-2018). Self-reported sociodemographic characteristics were collected using a structured questionnaire. Clinical data were obtained through medical records. Patients were classified as screeners (last screening mammogram ≤ 2 years before diagnosis), non-screeners (aware but did not attend or last screen > 2years), and those unaware of MAM. Associations between MAM behaviour (MB) and sociodemographic factors and MB and tumour characteristics were examined using multinomial regression. Ten-year overall survival was modelled using Cox regression.
Results: Patients unaware of screening were more likely diagnosed with late stage (OR stage III vs stage I (Ref) [95% CI]: 4.94 [3.45-7.07], p < 0.001), high grade (OR poorly vs well-differentiated (reference) : 1.53 [1.06-2.20], p = 0.022), nodal-positive, large size (OR >5cm vs ≤2cm (reference) : 5.06 [3.10-8.25], p < 0.001), and HER2-positive tumours (OR HER2-negative vs HER2-positive (reference) : 0.72 [0.53-0.97], p = 0.028). Similar trends were observed between screeners and non-screeners with smaller effect sizes. Overall survival was significantly shorter than screeners in the both groups (HR non-screeners : 1.89 [1.22-2.94], p = 0.005; HR unaware : 2.90 [1.69-4.98], p < 0.001). Non-screeners and those unaware were less health conscious, older, of Malay ethnicity, less highly educated, of lower socioeconomic status, more frequently ever smokers, and less physically active. Among screeners, there were more reported personal histories of benign breast surgeries or gynaecological conditions and positive family history of breast cancer.
Conclusions: Mammography attendance is associated with more favourable BC characteristics and overall survival. Disparities in the utility of MAM services suggest that different strategies may be needed to improve MAM uptake.
(© 2022. The Author(s).)
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فهرسة مساهمة: Keywords: Breast cancer; Cancer survival; Mammography screening; Sociodemographics and health outcomes
تواريخ الأحداث: Date Created: 20220803 Date Completed: 20220805 Latest Revision: 20220807
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9351273
DOI: 10.1186/s12916-022-02440-y
PMID: 35922814
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-7015
DOI:10.1186/s12916-022-02440-y