دورية أكاديمية
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Genetic and Genomic Characterization of a New Beef Cattle Composite Breed (Purunã) Developed for Production in Pasture-Based Systems.

التفاصيل البيبلوغرافية
العنوان: Genetic and Genomic Characterization of a New Beef Cattle Composite Breed (Purunã) Developed for Production in Pasture-Based Systems.
المؤلفون: Mulim HA; Department of Animal Science, Federal University of Bahia, Salvador, Brazil., Brito LF; Department of Animal Sciences, Purdue University, West Lafayette, IN, United States., Batista Pinto LF; Department of Animal Science, Federal University of Bahia, Salvador, Brazil., Moletta JL; Agronomic Institute of Paraná-IAPAR, Ponta Grossa, Brazil., Da Silva LR; NEOGEN Corporation, Pindamonhangaba, Brazil., Pedrosa VB; Department of Animal Science, Federal University of Bahia, Salvador, Brazil.; Department of Animal Sciences, Purdue University, West Lafayette, IN, United States.; Department of Animal Science, State University of Ponta Grossa, Ponta Grossa, Brazil.
المصدر: Frontiers in genetics [Front Genet] 2022 Jul 18; Vol. 13, pp. 858970. Date of Electronic Publication: 2022 Jul 18 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation.
مستخلص: Purunã is a composite beef cattle breed, developed in Southern Brazil by crossing the Angus, Charolais, Canchim, and Caracu breeds. The goal of this study was to perform the first genetic characterization of the Purunã breed, based on both pedigree and genomic information. For this, 100 randomly selected animals were genotyped, and 11,205 animals born from 1997 to 2019 had pedigree information. The genetic analyses performed were principal component analysis, admixture, phylogenic tree, pedigree and genomic inbreeding, linkage disequilibrium (LD), effective population size (Ne), consistency of the gametic phase, runs of homozygosity (ROH), heterozygosity-enriched regions (HERs), and functional analyses of the ROH and HER regions identified. Our findings indicate that Purunã is more genetically related to the Charolais, Canchim, and Angus breeds than Caracu or Nellore. The levels of inbreeding were shown to be small based on all the metrics evaluated and ranged from -0.009 to 0.029. A low (-0.12-0.31) correlation of the pedigree-based inbreeding compared to all the genomic inbreeding coefficients evaluated was observed. The LD average was 0.031 (±0.0517), and the consistency of the gametic phase was shown to be low for all the breed pairs, ranging from 0.42 to 0.27 to the distance of 20 Mb. The Ne values based on pedigree and genomic information were 158 and 115, respectively. A total of 1,839 ROHs were found, and the majority of them are of small length (<4 Mb). An important homozygous region was identified on BTA5 with pathways related to behavioral traits (sensory perception, detection of stimulus, and others), as well as candidate genes related to heat tolerance ( MY O 1A ), feed conversion rate ( RDH5 ), and reproduction ( AMDHD1 ). A total of 1,799 HERs were identified in the Purunã breed with 92.3% of them classified within the 0.5-1 Mb length group, and 19 HER islands were identified in the autosomal genome. These HER islands harbor genes involved in growth pathways, carcass weight ( SDCBP ), meat and carcass quality ( MT2A ), and marbling deposition ( CISH ). Despite the genetic relationship between Purunã and the founder breeds, a multi-breed genomic evaluation is likely not feasible due to their population structure and low consistency of the gametic phase among them.
Competing Interests: Author LD is employed by the company NEOGEN Corporation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Mulim, Brito, Batista Pinto, Moletta, Da Silva and Pedrosa.)
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فهرسة مساهمة: Keywords: beef cattle; genomic diversity; inbreeding coefficient; persistency of the gametic phase; runs of heterozygosity; runs of homozygosity
تواريخ الأحداث: Date Created: 20220804 Latest Revision: 20220805
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9341487
DOI: 10.3389/fgene.2022.858970
PMID: 35923708
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-8021
DOI:10.3389/fgene.2022.858970