دورية أكاديمية
Spike-heparan sulfate interactions in SARS-CoV-2 infection.
| العنوان: | Spike-heparan sulfate interactions in SARS-CoV-2 infection. |
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| المؤلفون: | Kearns FL; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/fiona_chembot., Sandoval DR; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Casalino L; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/LCasalino88., Clausen TM; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Rosenfeld MA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/mia_rosenfeld., Spliid CB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Amaro RE; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: https://twitter.com/RommieAmaro., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jesko@health.ucsd.edu. |
| المصدر: | Current opinion in structural biology [Curr Opin Struct Biol] 2022 Oct; Vol. 76, pp. 102439. Date of Electronic Publication: 2022 Jul 06. |
| نوع المنشور: | Journal Article; Review; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9107784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-033X (Electronic) Linking ISSN: 0959440X NLM ISO Abbreviation: Curr Opin Struct Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: London : Elsevier Science Original Publication: London, UK : Current Biology, 1991- |
| مواضيع طبية MeSH: | COVID-19*, Angiotensin-Converting Enzyme 2 ; Asparagine/metabolism ; Binding Sites ; Heparitin Sulfate ; Humans ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism |
| مستخلص: | Recent biochemical, biophysical, and genetic studies have shown that heparan sulfate, a major component of the cellular glycocalyx, participates in infection of SARS-CoV-2 by facilitating the so-called open conformation of the spike protein, which is required for binding to ACE2. This review highlights the involvement of heparan sulfate in the SARS-CoV-2 infection cycle and argues that there is a high degree of coordination between host cell heparan sulfate and asparagine-linked glycans on the spike in enabling ACE2 binding and subsequent infection. The discovery that spike protein binding and infection depends on both viral and host glycans provides insights into the evolution, spread and potential therapies for SARS-CoV-2 and its variants. Competing Interests: Conflict of interest J.D.E is a cofounder and T.M.C., and D.R.S. are consultants of Covicept Therapeutics, Inc. J.D.E. and the Regents of the University of California have licensed a university invention to and have an equity interest in TEGA Therapeutics, Inc., a vendor for heparan sulfate. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| معلومات مُعتمدة: | P01 HL131474 United States HL NHLBI NIH HHS; R01 GM132826 United States GM NIGMS NIH HHS; T32 DK007044 United States DK NIDDK NIH HHS; U19 AI171954 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Spike Glycoprotein, Coronavirus) 0 (spike protein, SARS-CoV-2) 7006-34-0 (Asparagine) 9050-30-0 (Heparitin Sulfate) EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) |
| تواريخ الأحداث: | Date Created: 20220804 Date Completed: 20220928 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| مُعرف محوري في PubMed: | PMC9257145 |
| DOI: | 10.1016/j.sbi.2022.102439 |
| PMID: | 35926454 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-033X |
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| DOI: | 10.1016/j.sbi.2022.102439 |