دورية أكاديمية
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model.
العنوان: | Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model. |
---|---|
المؤلفون: | Aknouch I; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands.; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands.; Viroclinics Xplore, Schaijk, The Netherlands., Sridhar A; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands a.sridhar@amsterdamumc.nl d.pajkrt@amsterdamumc.nl.; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands., Freeze E; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands.; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands., Giugliano FP; Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology and Metabolism, Tytgat Institute for Intestinal and Liver Research, Amsterdam, The Netherlands., van Keulen BJ; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Vrije Universiteit Emma Children's Hospital, Dutch National Human Milk Bank, Amsterdam, The Netherlands., Romijn M; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Vrije Universiteit Emma Children's Hospital, Dutch National Human Milk Bank, Amsterdam, The Netherlands., Calitz C; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands.; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands., García-Rodríguez I; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands.; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands., Mulder L; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands.; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands., Wildenberg ME; Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology and Metabolism, Tytgat Institute for Intestinal and Liver Research, Amsterdam, The Netherlands., Muncan V; Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology and Metabolism, Tytgat Institute for Intestinal and Liver Research, Amsterdam, The Netherlands., van Gils MJ; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., van Goudoever JB; Department of Pediatrics, Amsterdam UMC, University of Amsterdam, Vrije Universiteit Emma Children's Hospital, Dutch National Human Milk Bank, Amsterdam, The Netherlands., Stittelaar KJ; Department of Epidemiology, Bioinformatics and Animals Models, Wageningen University, Wageningen Bioveterinary Research, Wageningen, The Netherlands., Wolthers KC; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands., Pajkrt D; Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands a.sridhar@amsterdamumc.nl d.pajkrt@amsterdamumc.nl. |
المصدر: | Life science alliance [Life Sci Alliance] 2022 Aug 04; Vol. 5 (12). Date of Electronic Publication: 2022 Aug 04. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Woodbury, NY] : Life Science Alliance, LLC, [2018]- |
مواضيع طبية MeSH: | COVID-19* , SARS-CoV-2*, Antibodies, Viral ; Antiviral Agents/pharmacology ; Humans ; Milk, Human |
مستخلص: | Human milk is important for antimicrobial defense in infants and has well demonstrated antiviral activity. We evaluated the protective ability of human milk against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a human fetal intestinal cell culture model. We found that, in this model, human milk blocks SARS-CoV-2 replication, irrespective of the presence of SARS-CoV-2 spike-specific antibodies. Complete inhibition of both enveloped Middle East respiratory syndrome coronavirus and human respiratory syncytial virus infections was also observed, whereas no inhibition of non-enveloped enterovirus A71 infection was seen. Transcriptome analysis after 24 h of the intestinal monolayers treated with human milk showed large transcriptomic changes from human milk treatment, and subsequent analysis suggested that <i>ATP1A1</i> down-regulation by milk might be of importance. Inhibition of ATP1A1 blocked SARS-CoV-2 infection in our intestinal model, whereas no effect on EV-A71 infection was seen. Our data indicate that human milk has potent antiviral activity against particular (enveloped) viruses by potentially blocking the ATP1A1-mediated endocytic process. (© 2022 Aknouch et al.) |
References: | Science. 2020 Mar 13;367(6483):1260-1263. (PMID: 32075877) Am J Cardiovasc Drugs. 2007;7(3):173-89. (PMID: 17610345) J Virol. 2015 Apr;89(8):4434-48. (PMID: 25653449) Nat Med. 2020 Jul;26(7):1077-1083. (PMID: 32405028) Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7. (PMID: 27141961) Bioinformatics. 2013 Dec 1;29(23):3060-6. (PMID: 24045772) Genome Biol. 2021 Aug 23;22(1):242. (PMID: 34425859) Viruses. 2020 Nov 23;12(11):. (PMID: 33238561) Patterns (N Y). 2020 Sep 11;1(6):100090. (PMID: 32838343) Lancet. 2020 May 9;395(10235):1481. (PMID: 32353326) Clin Infect Dis. 2020 Nov 19;71(16):2236-2239. (PMID: 32297925) Innovation (Camb). 2021 Jul 01;2(3):100141. (PMID: 34557778) Nature. 2009 May 14;459(7244):262-5. (PMID: 19329995) Biometals. 2004 Jun;17(3):295-9. (PMID: 15222481) Euro Surveill. 2014 May 29;19(21):. (PMID: 24906375) Int Breastfeed J. 2021 Oct 18;16(1):83. (PMID: 34663389) BMC Bioinformatics. 2013 Apr 15;14:128. (PMID: 23586463) PLoS Pathog. 2019 Aug 5;15(8):e1007963. (PMID: 31381610) J Gen Virol. 1992 Apr;73 ( Pt 4):995-8. (PMID: 1634881) J Hum Lact. 2021 Aug;37(3):469-476. (PMID: 33982613) Genomics. 2004 Sep;84(3):587-91. (PMID: 15498465) Jpn J Med Sci Biol. 1994 Apr;47(2):73-85. (PMID: 7853749) J Nutr. 2008 Sep;138(9):1801S-1806S. (PMID: 18716190) OMICS. 2012 May;16(5):284-7. (PMID: 22455463) Bioorg Med Chem. 2006 Oct 1;14(19):6486-91. (PMID: 16828555) J Exp Med. 2021 Mar 1;218(3):. (PMID: 33231615) PLoS One. 2013 Aug 14;8(8):e70867. (PMID: 23967126) Lancet. 2020 Jun 6;395(10239):1757-1758. (PMID: 32446324) Arch Virol. 2020 Jul;165(7):1517-1526. (PMID: 32322993) J Infect Dis. 1995 Aug;172(2):380-8. (PMID: 7622881) Clin Microbiol Rev. 2000 Jul;13(3):371-84. (PMID: 10885982) PLoS One. 2021 Aug 4;16(8):e0255335. (PMID: 34347801) Nature. 2020 Jul;583(7815):E22. (PMID: 32555542) J Med Microbiol. 2021 May;70(5):. (PMID: 34038343) Am J Respir Cell Mol Biol. 2018 Aug;59(2):145-157. (PMID: 29624415) Int J Clin Pract. 2021 Jul;75(7):e14175. (PMID: 33763939) Sci Rep. 2020 Oct 1;10(1):16200. (PMID: 33004837) Front Nutr. 2020 Aug 25;7:136. (PMID: 32984396) Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):. (PMID: 34452991) Front Immunol. 2023 Jan 05;13:1060438. (PMID: 36685600) Front Cell Infect Microbiol. 2020 Jun 09;10:272. (PMID: 32656095) JAMA Pediatr. 2021 Mar 1;175(3):260-266. (PMID: 33284345) N Engl J Med. 2020 May 7;382(19):e49. (PMID: 32320556) Curr Top Microbiol Immunol. 2013;372:3-38. (PMID: 24362682) Int J Clin Pract. 2021 Oct;75(10):e14606. (PMID: 34228870) Nat Microbiol. 2021 Oct;6(10):1219-1232. (PMID: 34471255) Curr Protoc. 2021 Mar;1(3):e90. (PMID: 33780170) Biomedicines. 2021 Mar 26;9(4):. (PMID: 33810394) Arch Dis Child Fetal Neonatal Ed. 2022 Mar;107(2):216-221. (PMID: 34417223) Antiviral Res. 2002 Aug;55(2):341-55. (PMID: 12103434) J Hum Lact. 2021 Aug;37(3):485-491. (PMID: 34308720) Lancet. 1985 Apr 20;1(8434):896-8. (PMID: 2858746) BMC Bioinformatics. 2020 Jun 29;21(1):267. (PMID: 32600310) Hypertension. 2005 May;45(5):1024-8. (PMID: 15837822) Pediatr Res. 1977 Dec;11(12):1177-9. (PMID: 22838) mBio. 2021 Feb 9;12(1):. (PMID: 33563823) J Clin Invest. 2015 Mar 2;125(3):1215-27. (PMID: 25664854) Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2384-9. (PMID: 8146127) Lancet Child Adolesc Health. 2019 Apr;3(4):264-273. (PMID: 30878119) Curr Opin Virol. 2018 Apr;29:79-86. (PMID: 29656244) Cell Mol Gastroenterol Hepatol. 2021;11(4):935-948. (PMID: 33186749) BioData Min. 2014 Apr 29;7:3. (PMID: 24872843) JAMA. 2020 Oct 6;324(13):1347-1348. (PMID: 32822495) Science. 2020 Aug 7;369(6504):643-650. (PMID: 32540902) Matern Child Nutr. 2020 Oct;16(4):e13032. (PMID: 32472745) Science. 2020 Jul 3;369(6499):50-54. (PMID: 32358202) Nutrients. 2021 May 13;13(5):. (PMID: 34068142) PLoS Pathog. 2020 Oct 30;16(10):e1009037. (PMID: 33125439) J Gen Virol. 1988 Nov;69 ( Pt 11):2797-807. (PMID: 3183629) Nat Microbiol. 2021 Mar;6(3):339-353. (PMID: 33349665) Eur J Biochem. 1985 Apr 15;148(2):353-7. (PMID: 2859195) Ann N Y Acad Sci. 2021 Jan;1484(1):32-54. (PMID: 32860259) iScience. 2020 Nov 20;23(11):101735. (PMID: 33134887) |
سلسلة جزيئية: | GENBANK NC_019843 |
المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Antiviral Agents) |
تواريخ الأحداث: | Date Created: 20220804 Date Completed: 20220808 Latest Revision: 20240902 |
رمز التحديث: | 20240902 |
مُعرف محوري في PubMed: | PMC9354649 |
DOI: | 10.26508/lsa.202201432 |
PMID: | 35926873 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2575-1077 |
---|---|
DOI: | 10.26508/lsa.202201432 |