دورية أكاديمية
Machine operator's lung outbreak due to Eikenella corrodens.
| العنوان: | Machine operator's lung outbreak due to Eikenella corrodens. |
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| المؤلفون: | Perečinský S; Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef Šafárik University and the L. Pasteur University Hospital, Rastislavova, Kosice, Slovak Republic., Murínová L; Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef Šafárik University and the L. Pasteur University Hospital, Rastislavova, Kosice, Slovak Republic., Tomčová J; Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef Šafárik University and the L. Pasteur University Hospital, Rastislavova, Kosice, Slovak Republic., Poľanová M; Department of Clinical Microbiology, The National Institute of Tuberculosis, Respiratory Diseases and Thoracic Surgery, Vyšné Hágy, Vysoké Tatry, Slovak Republic., Legáth Ľ; Department of Occupational Medicine and Clinical Toxicology, Medical Faculty, Pavol Jozef Šafárik University and the L. Pasteur University Hospital, Rastislavova, Kosice, Slovak Republic. |
| المصدر: | Occupational medicine (Oxford, England) [Occup Med (Lond)] 2022 Dec 07; Vol. 72 (8), pp. 522-526. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9205857 Publication Model: Print Cited Medium: Internet ISSN: 1471-8405 (Electronic) Linking ISSN: 09627480 NLM ISO Abbreviation: Occup Med (Lond) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : London : Oxford University Press Original Publication: Oxford, UK : Published quarterly on behalf of the Society of Occupational Medicine by Butterworth-Heinemann, c1992- |
| مواضيع طبية MeSH: | Eikenella corrodens* , Lung*, Female ; Humans ; Europe |
| مستخلص: | Background: Outbreaks of hypersensitivity pneumonitis (HP) are not uncommon in workplaces where metalworking fluids (MWFs) are used. The recirculation of MWFs leads to microbiological contamination, which is responsible for outbreaks. Most outbreak reports come from USA and the UK; however, no similar reports have been published from Central Europe. Aims: To describe an outbreak of MWF-associated HP in workers from a compressor assembly manufacturing facility in Slovak Republic and to identify the potential antigens responsible for the outbreak. Methods: We investigated the history of worker's symptoms, physical examinations, lung function tests, radiographic scans and lung biopsies. The MWF samples were analysed for different strains of bacteria and fungi. Antigen extracts were produced from the microorganisms isolated from MWFs, and positive precipitin reactions were evaluated. Results: MWF-associated HP was diagnosed in 21 men and 6 women. All workers had work-related dyspnoea and cough with abnormal pulmonary diffusing capacity. Twenty-four cases had evidence of interstitial lung disease. Four cases were classified as having fibrotic HP. Nineteen microbial isolates (12 bacteria and 7 fungi) were cultured from the MWFs. Twenty-five cases had a positive response to at least one isolate. Eikenella corrodens and Bacillus subtilis were the most frequently reacting antigens (in 15 and 12 workers, respectively). Conclusions: Despite decreasing reports of MWF-associated HP outbreaks over the past several decades, we describe one of the largest outbreaks in Europe. While the bacterium E. corrodens was found in the MWF samples, its relationship to the disease should be further investigated. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| تواريخ الأحداث: | Date Created: 20220806 Date Completed: 20221215 Latest Revision: 20231003 |
| رمز التحديث: | 20231003 |
| DOI: | 10.1093/occmed/kqac077 |
| PMID: | 35932246 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1471-8405 |
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| DOI: | 10.1093/occmed/kqac077 |