دورية أكاديمية
Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anticolon cancer, and anti-Alzheimer potentials.
| العنوان: | Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anticolon cancer, and anti-Alzheimer potentials. |
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| المؤلفون: | Zhang M; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, China., Xue J; Health Management Center, QingDao Municipal Hospital, QingDao, ShanDong Province, China., Chen X; Second Department of Encephalopathy, Xi'an Chinese Medicine Hospital, Xi'an, Shaanxi, China., Elsaid FG; Department of Biology, Science College, King Khalid University, Abha, Saudi Arabia.; Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt., Salem ET; Department of Basic Science, Faculty of Physical Therapy, Horus University-Egypt, New Damietta, Egypt., Ghanem RA; Department of Oral biology, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Gamasa, Egypt., El-Kott AF; Department of Biology, Science College, King Khalid University, Abha, Saudi Arabia.; Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt., Xu Z; Department of Gastrointestinal Surgery, Jinan Central Hospital, No.105, Jiefang Road, Jinan, Shangdong, China. |
| المصدر: | Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2023 Apr; Vol. 70 (2), pp. 730-745. Date of Electronic Publication: 2022 Aug 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8609465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8744 (Electronic) Linking ISSN: 08854513 NLM ISO Abbreviation: Biotechnol Appl Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Malden : Wiley-Blackwell Original Publication: San Diego : Academic Press, [cl986]- |
| مواضيع طبية MeSH: | Alzheimer Disease*/drug therapy , Neoplasms*, Humans ; Butyrylcholinesterase/metabolism ; Molecular Docking Simulation ; Acetylcholinesterase/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Resveratrol/pharmacology ; Molecular Structure ; Structure-Activity Relationship |
| مستخلص: | In this study, we worked on anticolon cancer effects and anti-Alzheimer's disease with molecular docking studies. Hamamelitannin, flavokawain A, and triacetyl resveratrol compounds showed good inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. The inhibition effects of flavokawain A, hamamelitannin, and triacetyl resveratrol on AChE and BuChE enzymes were determined spectrophotometrically conforming to Ellman. IC (© 2022 International Union of Biochemistry and Molecular Biology, Inc.) |
| References: | Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000;47:549-55. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997;275:218-20. Urbain A, Marston A, Queiroz EF, Ndjoko K. Hostettmann Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004;70:1011-4. Sung SH, Kang SY, Lee KY, Park MJ, Kim JH, Park JH, et al. (+)-α-Viniferin, a stilbene trimer from Caragana chamlague inhibits acetylcholinesterase. Biol Pharm Bull. 2002;25:125-7. Roddick JG. The acetylcholinesterase inhibitory activity of steroidal glycoalkaloids and their aglycones. Phytochemistry. 1989;28:2631-4. Rhee IK, Meent MV, Ingkaninan K, Verpoorte R. Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. J Chromatogr A. 2001;915:217-23. Perry NSL, Houghton PG, Theolad AE, Jenner P, Perry EK. In vitro inhibition of human erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol. 2000;52:895-902. Orhan I, Sener B, Choudhary MI, Khalid A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J Ethnopharmacol. 2004;91:57-60. Marston A, Kissling J, Hostettmann K. A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants. Phytochem Anal. 2002;13:51-54. Brlihlmann C, Marston A, Hostettmann K, Carrupt PA, Testa B. Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors. Chem Biodivers. 2004;1:819-29. Mihǎşan M. What in silico molecular docking can do for the “bench-working biologists.” J Biosci. 2012;37, no. 6:1089-95. B-Rao C, Subramanian J, Sharma SD. Managing protein flexibility in docking and its applications.” Drug Discovery Today. 2009;14:394-400. Meng X-Y, Zhang H-X, Mezei M, Cui M. Molecular docking: a powerful approach for structure-based drug discovery.” Current Computer Aided-Drug Design. 2012;7:146-57. Fan J, Fu A, Zhang L. Progress in molecular docking.” Quantitative Biology. 2019;7:83-89. Borges-Canha M, Portela-Cidade JP, Dinis-Ribeiro M, et al. Role of colonic microbiota in colorectal carcinogenesis: a systematic review. Rev Esp Enferm Dig. 2015;107:659-71. Saunders MD, Kimmey MB. Colonic pseudo-obstruction: the dilated colon in the ICU. Semin Gastrointest Dis. 2003;14:20-27. Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88-95. Chung YK, Heo HJ, Kim EK, Kim HK, Huh TL, Lim Y, et al. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol Cells. 2001;11:137-43. Liu Z-B, Zhang T, Ye X, Liu Z-Q, Sun X, Zhang L-L, et al. Natural substances derived from herbs or plants are promising sources of anticancer agents against colorectal cancer via triggering apoptosis. J Pharm Pharmacol. 2022;74:162-78. Cheung J, Gary EN, Shiomi K, Rosenberry TL. Structures of human acetylcholinesterase bound to dihydrotanshinone i and territrem B show peripheral site flexibility.” ACS Med Chem Lett. Nov. 2013;4:1091-6,. Rosenberry TL et al., Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: a crystallographic, kinetic and calorimetric study.” Molecules. 2017;22. https://doi.org/10.3390/molecules22122098. “Schrödinger Release 2020-4: Protein Preparation Wizard; Epik, Schrödinger, LLC, New York, NY 2016; Impact, Schrödinger, LLC, New York, NY 2016; Prime, Schrödinger, LLC, New York, NY 2020.”. Chigurupati S, Selvaraj M, Mani V, Selvarajan KK, Mohammad JI, Kaveti B, et al. Identification of novel acetylcholinesterase inhibitors: indolopyrazoline derivatives and molecular docking studies. Bioorg Chem. 2016;67:9-17. “Schrödinger Release 2020-4: LigPrep, Schrödinger, LLC, New York, NY 2020.”. Nascimento ECM, Martins JBL, Gargano R, Santos ML. Theoretical study of classical acetylcholinesterase inhibitors. Chem Phys Lett. 2008;458:285-9. Nascimento ECM, Martins JBL. Electronic structure and PCA analysis of covalent and non-covalent acetylcholinesterase inhibitors. J Mol Model. 2011;17:1371-9. Kiametis AS, Martins JBL, Romeiro LAS, Gargano R. Acetylcholinesterase inhibitors: modeling potential candidates. Int J Quantum Chem. 2013;113:1461-6. Castro A, Martinez A. Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors. Curr Pharm Des. 2006;12:4377-87. Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP. Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. Biochemistry. 1997;36(48):14642-51. Rajesh RV, Chitra L, Layer PG, Boopathy R. The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie. 2009a;91 (9):1087-94. Manoharan I, Boopathy R, Darvesh S, Lockridge O. A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India. Clin Chim Acta. 2007;378(1-2):128-35. Lockridge O. Substance P hydrolysis by human serum cholinesterase. J Neurochem. 1982;39(1):106-10. Rajesh RV, Layer PG, Boopathy R. High aryl acylamidase activity associated with cobra venom acetylcholinesterase: biological significance. Biochimie. 2009b;91 (11-12):1450-6. Larrimore KE, Kazan IC, Kannan L, Kendle RP, Jamal T, Barcus M, et al. Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity. Sci Rep. 2017;7:1-14,. Türe A, Kahraman DC, Cetin-Atalay R, Helvacıoğlu S, Charehsaz M, Küçükgüzel İ. Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine-(thio)urea hybrids as potential kinase inhibitors.” Comput Biol Chem. 2019;78:227-41,. Scarano A, Chieppa M, Santino A. Looking at flavonoid biodiversity in horticultural crops: a colored mine with nutritional benefits. Plants-Basel. 2018;7:1-22. Lin M, Zhang J, Chen X. Bioactive flavonoids in Moringa oleifera and their health-promoting properties. J Funct Foods. 2018;47:469-79. Aranganathan S, Selvam JP, Nalini N. Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study. J Pharm Pharmacol. 2008;60(10);1385-92. Fenton JI, Hord NG. Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity. Nutr Cancer. 2004;48(2);182-8. Kuntz S, Wenzel U, Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr. 1999;38(3):133-42. |
| فهرسة مساهمة: | Keywords: anticolon cancer; cholinesterase enzymes; enzyme inhibition; molecular modeling; natural compounds |
| المشرفين على المادة: | EC 3.1.1.8 (Butyrylcholinesterase) EC 3.1.1.7 (Acetylcholinesterase) 0 (Cholinesterase Inhibitors) Q369O8926L (Resveratrol) Z4320A2K26 (hamamelitannin) 0 (flavokawain A) |
| تواريخ الأحداث: | Date Created: 20220807 Date Completed: 20230414 Latest Revision: 20230414 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/bab.2394 |
| PMID: | 35933706 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1470-8744 |
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| DOI: | 10.1002/bab.2394 |