دورية أكاديمية
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Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.

التفاصيل البيبلوغرافية
العنوان: Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom.
المؤلفون: Monteiro ML; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., Lima DB; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., Freire KA; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, 09210580, SP, Brazil., Nicolaski Pedron C; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, 09210580, SP, Brazil., Magalhães EP; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., Silva BP; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., García-Jareño AB; Targeted Therapies on Cancer and Inflammation Lab and Peptide Synthesis Platform, Centro de Investigación Príncipe Felipe, Valencia, 46012, Spain., De Oliveira CS; Department of Biophysics, Universidade Federal de São Paulo, São Paulo, SP, 04044020, Brazil., Nunes JVS; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., Marinho MM; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., Menezes RRPPB; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil., Orzaéz M; Targeted Therapies on Cancer and Inflammation Lab and Peptide Synthesis Platform, Centro de Investigación Príncipe Felipe, Valencia, 46012, Spain., Oliveira Junior VX; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, 09210580, SP, Brazil; Department of Biophysics, Universidade Federal de São Paulo, São Paulo, SP, 04044020, Brazil., Martins AMC; Department of Clinical and Toxicological Analysis, Faculdade de Farmácia, Universidade Federal do Ceará, Fortaleza, 60430372, CE, Brazil. Electronic address: martinsalice@gmail.com.
المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Nov 05; Vol. 241, pp. 114624. Date of Electronic Publication: 2022 Jul 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: Paris, S.E.C.T. [etc.]
مواضيع طبية MeSH: Chagas Disease*/drug therapy , Trypanocidal Agents*/therapeutic use , Trypanosoma cruzi*, Humans ; Peptides/pharmacology ; Peptides/therapeutic use ; Venoms
مستخلص: Chagas disease is caused by the parasite Trypanosoma cruzi and affects millions of people worldwide, having no effective cure. The main sanitary emergency is related to patients with chronic infection, which accumulate comorbidities causing patient death. However, actual chemotherapeutic treatments do not effectively address the chronic forms of the disease. Invertebrates are a relevant source of antimicrobial peptides (AMPs) as part of the innate immune system for their protection. The AMP M-PONTX-Dq3a, isolated from the Dinoponera quadriceps ant venom, has shown very effective antimicrobial and trypanocidal activities. Although M-PONTX-Dq3a has better activity that the current therapies, the peptide length has limited its possibilities to reach clinical application. In this investigation, we aimed to dissect the trypanocidal effect of M-PONTX-Dq3a fragments and to study the activity of substituted analogs, to improve not only peptide trypanocidal activity and bioavailability, but also production costs. Our studies have led to the identification of two smaller peptides, M-PONTX-Dq3a [1-15] and [Lys] 3 -M-PONTX-Dq3a [3-153-15 with similar trypanocidal activities that the parent peptide has against the three forms of T. cruzi benznidazole-resistant Y strain. Both peptides represent promising candidates to develop novel and effective trypanocidal bio-therapeutic agents, opening new avenues for the treatment of chronic patients.
(Copyright © 2022 Elsevier Masson SAS. All rights reserved.)
فهرسة مساهمة: Keywords: Ant venom peptide; Antimicrobial peptides; Chagas disease; M-PONTX-Dq3a; Trypanosoma cruzi
المشرفين على المادة: 0 (Peptides)
0 (Trypanocidal Agents)
0 (Venoms)
تواريخ الأحداث: Date Created: 20220807 Date Completed: 20220901 Latest Revision: 20220906
رمز التحديث: 20221213
DOI: 10.1016/j.ejmech.2022.114624
PMID: 35933786
قاعدة البيانات: MEDLINE
الوصف
تدمد:1768-3254
DOI:10.1016/j.ejmech.2022.114624