دورية أكاديمية
أعرض في EDS

Clinicopathology and Treatment Patterns of Head and Neck Cancers in Ethiopia.

التفاصيل البيبلوغرافية
العنوان: Clinicopathology and Treatment Patterns of Head and Neck Cancers in Ethiopia.
المؤلفون: Fekadu A; Department of Radiation Oncology, Addis Ababa University, Addis Ababa, Ethiopia., Rick TJ; Department of Radiation Oncology, Erasmus MC, Rotterdam, the Netherlands., Tigeneh W; Department of Radiation Oncology, Addis Ababa University, Addis Ababa, Ethiopia., Kantelhardt EJ; Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Incrocci L; Department of Radiation Oncology, Erasmus MC, Rotterdam, the Netherlands., Jemal A; Surveillance and Health Service Research, American Cancer Society, Atlanta, GA.
المصدر: JCO global oncology [JCO Glob Oncol] 2022 Aug; Vol. 8, pp. e2200073.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101760170 Publication Model: Print Cited Medium: Internet ISSN: 2687-8941 (Electronic) Linking ISSN: 26878941 NLM ISO Abbreviation: JCO Glob Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Alexandria, VA : American Society of Clinical Oncology, [2020]-
مواضيع طبية MeSH: Head and Neck Neoplasms*/epidemiology , Head and Neck Neoplasms*/therapy, Cobalt ; Cross-Sectional Studies ; Ethiopia/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
مستخلص: Purpose: Head and neck cancers are the third most common cancers treated with radiation in Ethiopia. There is, however, a lack of published data on clinical and pathological characteristics and treatment patterns of head and neck cancers in the country. The objective of the study was to assess clinical and pathological characteristics and treatment patterns of head and neck cancers at Tikur Anbessa Specialized Hospital, which housed the only radiotherapy facility in Ethiopia during the study period.
Materials and Methods: A retrospective cross-sectional study design with a simple random sampling of histologically confirmed head and neck cancers treated from 2014 to 2017 with analysis of descriptive data.
Results: Three hundred twenty-one patient charts were analyzed in this study from a total population of 1,377 from the department cancer registry. The male to female ratio was 2:1. The median age was 45 years (interquartile range, 26-59). The most common primary site of head and neck cancers was nasopharynx (128 of 321, 40%), and the major histologic type was squamous cell carcinoma (285 of 321, 89%). Majority of the cases had advanced disease (stage III-IVC, 221 of 251, 88%), but 92% had potentially curable disease (231 of 321). Cobalt radiotherapy was used for 67% of all patients receiving treatment (184 of 273). Induction chemotherapy followed by radiotherapy was frequently used for curative intent patients (75 of 231, 32%). There was long duration between diagnosis and initiation of treatment, with 56% (148 of 264) waiting longer than 3 months.
Conclusion: Majority of patients with head and neck cancers seen in Ethiopia presented at advanced stage of disease, received cobalt radiotherapy, and had protracted treatment initiation. These findings underscore the need for additional investments to improve research capacity and increase the availability of high-quality radiotherapy and supportive services to deliver optimal care for patients with head and neck cancer and other cancer patients in the country.
Competing Interests: Tara J. RickResearch Funding: Varian Medical Systems (Inst)Travel, Accommodations, Expenses: Varian Medical Systems Luca IncrocciHonoraria: Varian Medical SystemsResearch Funding: Varian Medical Systems (Inst)No other potential conflicts of interest were reported.
References: Radiother Oncol. 2014 Mar;110(3):377-84. (PMID: 24630534)
BMC Cancer. 2021 May 12;21(1):540. (PMID: 33980204)
Lancet. 2019 Jul 6;394(10192):64-80. (PMID: 31178151)
Lancet. 2003 Sep 20;362(9388):933-40. (PMID: 14511925)
J Natl Cancer Inst. 2015 Dec 16;108(4):. (PMID: 26681800)
Trop Doct. 2005 Jan;35(1):2-4. (PMID: 15712528)
Oral Oncol. 2014 Apr;50(4):282-90. (PMID: 24405882)
Lancet Oncol. 2011 Feb;12(2):153-9. (PMID: 21233014)
Pract Radiat Oncol. 2017 Jul - Aug;7(4):246-253. (PMID: 28428019)
J Glob Oncol. 2019 Feb;5:1-8. (PMID: 30763144)
Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):230-235. (PMID: 31928635)
Health Educ Behav. 2016 Aug;43(4):420-7. (PMID: 27091222)
Lancet. 2013 Jun 29;381(9885):2238-9. (PMID: 23388077)
Int J Radiat Oncol Biol Phys. 2008 Dec 1;72(5):1368-77. (PMID: 18455329)
N Engl J Med. 2007 Oct 25;357(17):1695-704. (PMID: 17960012)
Laryngoscope. 1995 Mar;105(3 Pt 1):247-50. (PMID: 7877412)
Lancet Oncol. 2013 Apr;14(4):e142-51. (PMID: 23561745)
J Clin Oncol. 2015 Oct 10;33(29):3262-8. (PMID: 26351339)
J Clin Oncol. 2016 Mar 1;34(7):684-90. (PMID: 26729432)
Int J Radiat Oncol Biol Phys. 2014 May 1;89(1):13-20. (PMID: 24613816)
Radiother Oncol. 2021 Mar;156:281-293. (PMID: 33515668)
Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):929-36. (PMID: 11958885)
BMC Med. 2014 Dec 18;12:243. (PMID: 25518855)
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1765-77. (PMID: 17035381)
J Clin Oncol. 2014 Sep 1;32(25):2735-43. (PMID: 25049329)
J Clin Oncol. 2005 Dec 1;23(34):8636-45. (PMID: 16275937)
JCO Glob Oncol. 2021 Sep;7:1500-1508. (PMID: 34665667)
Am J Transl Res. 2016 Nov 15;8(11):4532-4547. (PMID: 27904660)
Oncologist. 2010;15(9):994-1001. (PMID: 20798198)
Medicine (Baltimore). 2017 Jun;96(26):e7285. (PMID: 28658124)
Otolaryngol Head Neck Surg. 2020 Mar;162(3):296-303. (PMID: 31906785)
J Glob Oncol. 2019 Nov;5:1-8. (PMID: 31834831)
Int J Radiat Oncol Biol Phys. 2000 Aug 1;48(1):7-16. (PMID: 10924966)
Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):998-1004. (PMID: 20338694)
المشرفين على المادة: 3G0H8C9362 (Cobalt)
تواريخ الأحداث: Date Created: 20220808 Date Completed: 20220810 Latest Revision: 20221013
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9470133
DOI: 10.1200/GO.22.00073
PMID: 35939776
قاعدة البيانات: MEDLINE
الوصف
تدمد:2687-8941
DOI:10.1200/GO.22.00073