دورية أكاديمية
Exploring Factors Associated with Decisions about Feminizing Genitoplasty in Differences of Sex Development.
| العنوان: | Exploring Factors Associated with Decisions about Feminizing Genitoplasty in Differences of Sex Development. |
|---|---|
| المؤلفون: | Kremen J; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: jessica.kremen@childrens.harvard.edu., Harris RM; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Aston CE; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma., Perez M; Oklahoma State University, Stillwater, Oklahoma., Austin PF; Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., Baskin L; University of California San Francisco Medical Center, UCSF School of Medicine, San Francisco, California., Cheng EY; Lurie Children's Hospital of Chicago, Feinberg School of Medicine of Northwestern University, Chicago, Illinois., Fried A; John R. Oishei Children's Hospital, Buffalo, New York., Kolon T; Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania., Kropp B; Oklahoma State University, Stillwater, Oklahoma; OKC Kids, Oklahoma City, Oklahoma., Lakshmanan Y; Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan., Nokoff NJ; Childrens Hospital of Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Palmer B; Cook Children's Medical Center, University of Oklahoma, College of Medicine, Oklahoma City, Oklahoma., Paradis A; St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri., Poppas D; New York Presbyterian Hospital, Weill Cornell Medical College, New York City, New York., Reyes KJS; Cook Children's Medical Center, University of Oklahoma, College of Medicine, Oklahoma City, Oklahoma., Wolfe-Christensen C; Cook Children's Medical Center, University of Oklahoma, College of Medicine, Oklahoma City, Oklahoma., Diamond DA; Golisano Children's Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York., Tishelman AC; Boston College, Morrissey College of Arts and Sciences, Boston, Massachusetts., Mullins LL; Oklahoma State University, Stillwater, Oklahoma., Wisniewski AB; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma., Chan YM; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. |
| المصدر: | Journal of pediatric and adolescent gynecology [J Pediatr Adolesc Gynecol] 2022 Dec; Vol. 35 (6), pp. 638-646. Date of Electronic Publication: 2022 Aug 07. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 9610774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4332 (Electronic) Linking ISSN: 10833188 NLM ISO Abbreviation: J Pediatr Adolesc Gynecol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: New York : Elsevier Science Original Publication: Philadelphia, PA : Chapman & Hall, 1996- |
| مواضيع طبية MeSH: | Adrenal Hyperplasia, Congenital*/psychology , Plastic Surgery Procedures*, Child ; Female ; Humans ; Infant ; Gynecologic Surgical Procedures ; Parents/psychology ; Sexual Development ; Virilism ; Longitudinal Studies |
| مستخلص: | Study Objective: Infants with genital development considered atypical for assigned female sex may undergo feminizing genitoplasty (clitoroplasty and/or vaginoplasty) in early life. We sought to identify factors associated with parent/caregiver decisions regarding genitoplasty for their children with genital virilization. Design: Longitudinal, observational study SETTING: Twelve pediatric centers in the United States with multidisciplinary differences/disorders of sex development clinics, 2015-2020 PARTICIPANTS: Children under 2 years old with genital appearance atypical for female sex of rearing and their parents/caregivers INTERVENTIONS/OUTCOME MEASURES: Data on the child's diagnosis and anatomic characteristics before surgery were extracted from the medical record. Parents/caregivers completed questionnaires on psychosocial distress, experience of uncertainty, cosmetic appearance of their child's genitalia, and demographic characteristics. Urologists rated cosmetic appearance. For 58 patients from the study cohort with genital virilization being raised as girls or gender-neutral, we compared these data across 3 groups based on the child's subsequent surgical intervention: (i) no surgery (n = 5), (ii) vaginoplasty without clitoroplasty (V-only) (n = 15), and (iii) vaginoplasty and clitoroplasty (V+C) (n = 38). Results: Fathers' and urologists' ratings of genital appearance were more favorable in the no-surgery group than in the V-only and V+C groups. Clitorophallic length was greater in the V+C group compared with the V-only group, with substantial overlap between groups. Mothers' depressive and anxious symptoms were lower in the no-surgery group compared with the V-only and V+C groups. Conclusions: Surgical decisions were associated with fathers' and urologists' ratings of genital appearance, the child's anatomic characteristics, and mothers' depressive and anxious symptoms. Further research on surgical decision-making is needed to inform counseling practices. (Copyright © 2022. Published by Elsevier Inc.) |
| التعليقات: | Comment in: J Pediatr Adolesc Gynecol. 2023 Feb;36(1):3-4. (PMID: 36336140) Comment in: J Pediatr Adolesc Gynecol. 2023 Apr;36(2):173. (PMID: 36574826) |
| References: | J Pediatr Urol. 2013 Dec;9(6 Pt B):1103-7. (PMID: 23693144) J Pediatr Psychol. 2017 Jun 1;42(5):544-558. (PMID: 27026663) J Pediatr Urol. 2022 Feb;18(1):36.e1-36.e17. (PMID: 34876378) Arch Sex Behav. 2021 Apr;50(3):913-923. (PMID: 33712989) J Pediatr Urol. 2006 Jun;2(3):148-62. (PMID: 18947601) Endocrine. 2021 Sep;73(3):723-733. (PMID: 34021489) J Adv Nurs. 2011 Oct;67(10):2220-30. (PMID: 21418287) J Pediatr Urol. 2020 Oct;16(5):568-575. (PMID: 32624410) J Urol. 2019 Nov;202(5):1046-1051. (PMID: 31268850) J Pediatr Urol. 2014 Feb;10(1):8-10. (PMID: 24528671) J Pediatr Psychol. 2005 Dec;30(8):631-43. (PMID: 15772363) Pediatrics. 2018 Aug;142(2):. (PMID: 30045929) J Endocr Soc. 2018 Dec 13;3(1):264-272. (PMID: 30623164) Endocr Dev. 2014;27:210-21. (PMID: 25247658) Endocr Rev. 2000 Jun;21(3):245-91. (PMID: 10857554) Int J Pediatr Endocrinol. 2017;2017:3. (PMID: 28149309) Acta Paediatr. 2015 Dec;104(12):1286-90. (PMID: 26524391) |
| معلومات مُعتمدة: | R01 HD074579 United States HD NICHD NIH HHS; U54 GM104938 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Congenital adrenal hyperplasia; Disorders of sex development; Intersex persons |
| تواريخ الأحداث: | Date Created: 20220810 Date Completed: 20221130 Latest Revision: 20231202 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9701156 |
| DOI: | 10.1016/j.jpag.2022.08.004 |
| PMID: | 35948206 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-4332 |
|---|---|
| DOI: | 10.1016/j.jpag.2022.08.004 |