تقرير
Lactotroph PitNET/adenoma associated to granulomatous hypophysitis in a patient with Crohn's disease: A case report.
| العنوان: | Lactotroph PitNET/adenoma associated to granulomatous hypophysitis in a patient with Crohn's disease: A case report. |
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| المؤلفون: | Pietrantoni A; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia and Pathology Service Spedali Civili of Brescia, Brescia, Italy., Serioli S; Neurosurgery, Department of Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Cominelli M; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia and Pathology Service Spedali Civili of Brescia, Brescia, Italy., Lodoli G; Neuroradiology, Spedali Civili of Brescia, Brescia, Italy., Stefini R; Department of Neurosurgery, ASST West Milan - Legnano Hospital, Milan, Italy., Villanacci V; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia and Pathology Service Spedali Civili of Brescia, Brescia, Italy., Poliani PL; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia and Pathology Service Spedali Civili of Brescia, Brescia, Italy. |
| المصدر: | Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2023 Feb; Vol. 43 (1), pp. 104-109. Date of Electronic Publication: 2022 Aug 10. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Asia Country of Publication: Australia NLM ID: 9606526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1789 (Electronic) Linking ISSN: 09196544 NLM ISO Abbreviation: Neuropathology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000-> : Melbourne, Australia : Blackwell Science Asia Original Publication: Sendai, Japan : The Society, [1993- |
| مواضيع طبية MeSH: | Crohn Disease*/complications , Lactotrophs* , Pituitary Neoplasms*/complications , Pituitary Neoplasms*/diagnosis , Hypophysitis*/complications , Hypophysitis*/diagnosis , Prolactinoma*/complications, Male ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/complications |
| مستخلص: | Granulomatous hypophysitis is a rare and poorly understood condition. Although certain cases are treated as primary pituitary autoimmune disorders, rare cases may be associated with pituitary neuroendocrine tumours (PitNETs) and systemic inflammatory diseases. Here, we report a case of a 47-year-old man that underwent endoscopic trans-sphenoidal excision of a pituitary mass diagnosed as PitNET. On histologic evaluation, the neoplasm showed an admixture of granulomas with extensive inflammatory infiltrate and lactotroph PitNET/adenoma. Careful anamnestic examination revealed a diagnosis of Crohn's disease 20 years prior. Although rarely done, both PitNET and Crohn's disease may be associated with granulomatous hypophysitis, and our patient had both conditions. During the 6-year follow-up, PitNETs and hypophysitis did not recur, while Crohn's disease was only partially controlled by medical therapy. To our knowledge, this is the first description of association of granulomatous hypophysitis, PitNET and Crohn's disease. (© 2022 The Authors. Neuropathology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Neuropathology.) |
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| فهرسة مساهمة: | Keywords: Crohn's disease; granulomatous disorders; hypophysitis; lactotroph PitNET/adenoma; pituitary neuroendocrine tumours |
| تواريخ الأحداث: | Date Created: 20220811 Date Completed: 20230203 Latest Revision: 20230413 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10087785 |
| DOI: | 10.1111/neup.12857 |
| PMID: | 35949102 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1440-1789 |
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| DOI: | 10.1111/neup.12857 |