دورية أكاديمية
To fight or not to fight: activation of the mPFC during decision to engage in aggressive behavior after ethanol consumption in a novel murine model.
| العنوان: | To fight or not to fight: activation of the mPFC during decision to engage in aggressive behavior after ethanol consumption in a novel murine model. |
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| المؤلفون: | Miczek KA; Department of Psychology, Tufts University, Medford, MB, 02155, USA. Klaus.Miczek@tufts.edu.; Department of Neuroscience, Tufts University, Boston, MA, 02111, USA. Klaus.Miczek@tufts.edu., Akdilek N; Department of Psychology, Tufts University, Medford, MB, 02155, USA., Ferreira VMM; Department of Psychology, Tufts University, Medford, MB, 02155, USA.; Universidade de Brasilea, Instituto de Psicologia, Brasilia, Brazil., Leonard MZ; Department of Psychology, Tufts University, Medford, MB, 02155, USA., Marinelli LR; Department of Psychology, Tufts University, Medford, MB, 02155, USA., Covington HE 3rd; Department of Psychology, Tufts University, Medford, MB, 02155, USA. |
| المصدر: | Psychopharmacology [Psychopharmacology (Berl)] 2022 Oct; Vol. 239 (10), pp. 3249-3261. Date of Electronic Publication: 2022 Aug 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Aggression* , Alcohol Drinking*, Animals ; Disease Models, Animal ; Ethanol/pharmacology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-fos |
| مستخلص: | Rationale: Alcohol consumption is a common antecedent of aggressive behavior. The effects of alcohol on the decision to engage in aggression in preference over pro-social interaction are hypothesized to arise from augmented function within the medial prefrontal cortex (mPFC). Objective: In a newly developed procedure, we studied social decision-making in male C57BL/6 J mice based on preferentially seeking access to either sociosexual interactions with a female partner or the opportunity to attack an intruder male. While deciding to engage in aggressive vs. sociosexual behavior, corresponding neural activation was assessed via c-Fos immunoreactivity in cortical, amygdaloid and tegmental regions of interest. A further objective was to investigate how self-administered alcohol impacted social choice. Methods: During repeated confrontations with an intruder male in their home cage, experimental mice engaged in species-specific sequence of pursuit, threat, and attack behavior within < 2 min. Mice were then conditioned to respond at one of two separate illuminated operanda in an experimental chamber (octagon) attached to their home cage; completion of 10 responses (fixed ratio 10; FR10) was reinforced by access to either a female or a male intruder which were presented in the resident's home cage. Brains were harvested following choice between the concurrently available aggressive and sociosexual options and processed for c-Fos immunoreactivity across 10 brain regions. In two separate groups, mice were trained to rapidly self-administer ethanol prior to a social choice trial in order to examine the effects of alcohol on social choice, sociosexual, aggressive acts and postures, and concurrent c-Fos activity in the mPFC and limbic regions. Results and Discussion: Eight out of 65 mice consistently chose to engage in aggressive behavior in preference to sociosexual contact with a female when each outcome was concurrently available. Self-administered alcohol (experiment 1: 1.2 ± 0.02 g/kg; experiment 2: 0, 1.0, 1.5, and 1.8 g/kg) increased responding for the aggressive option in mice that previously opted predominantly for access to sociosexual interactions with the female. When choosing the aggressive, but not the sociosexual option, the prelimbic area of the mPFC revealed increased c-Fos activity, guiding future detailed inquiry into the neural mechanisms for aggressive choice. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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(PMID: 10.1007/BF00428408) |
| معلومات مُعتمدة: | R01 AA013983 United States AA NIAAA NIH HHS; R01 DA031734 United States DA NIDA NIH HHS; AA013983 United States AA NIAAA NIH HHS; DA031734 United States DA NIDA NIH HHS |
| فهرسة مساهمة: | Keywords: Aggression; Chain schedule of reinforcement; Choice; Decision-making; Immediate early gene; Motivation; Prelimbic prefrontal cortex; Sexual behavior; Ventral tegmental area |
| المشرفين على المادة: | 0 (Proto-Oncogene Proteins c-fos) 3K9958V90M (Ethanol) |
| تواريخ الأحداث: | Date Created: 20220811 Date Completed: 20220920 Latest Revision: 20231002 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9481716 |
| DOI: | 10.1007/s00213-022-06208-3 |
| PMID: | 35951078 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-2072 |
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| DOI: | 10.1007/s00213-022-06208-3 |