دورية أكاديمية
Heritability of R2* iron in the basal ganglia and cortex.
| العنوان: | Heritability of R2* iron in the basal ganglia and cortex. |
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| المؤلفون: | Hofer E; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Styria, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Styria, Austria., Pirpamer L; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Styria, Austria., Langkammer C; Department of Neurology, Medical University of Graz, Styria, Austria., Tinauer C; Department of Neurology, Medical University of Graz, Styria, Austria., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA., Schmidt H; Research Unit-Genetic Epidemiology, Gottfried Schatz Research Centre for Cell Signalling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Styria, Austria., Schmidt R; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Styria, Austria. |
| المصدر: | Aging [Aging (Albany NY)] 2022 Aug 09; Vol. 14 (16), pp. 6415-6426. Date of Electronic Publication: 2022 Aug 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
| مواضيع طبية MeSH: | Basal Ganglia* , Iron*, Aged ; Brain ; Cerebral Cortex/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Middle Aged |
| مستخلص: | Background: While iron is essential for normal brain functioning, elevated concentrations are commonly found in neurodegenerative diseases and are associated with impaired cognition and neurological deficits. Currently, only little is known about genetic and environmental factors that influence brain iron concentrations. Methods: Heritability and bivariate heritability of regional brain iron concentrations, assessed by R2* relaxometry at 3 Tesla MRI, were estimated with variance components models in 130 middle-aged to elderly participants of the Austrian Stroke Prevention Family Study. Results: Heritability of R2* iron ranged from 0.46 to 0.82 in basal ganglia and from 0.65 to 0.76 in cortical lobes. Age and BMI explained up to 12% and 9% of the variance of R2* iron, while APOE ε4 carrier status, hypertension, diabetes, hypercholesterolemia, sex and smoking explained 5% or less. The genetic correlation of R2* iron among basal ganglionic nuclei and among cortical lobes ranged from 0.78 to 0.87 and from 0.65 to 0.97, respectively. R2* rates in basal ganglia and cortex were not genetically correlated. Conclusions: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes. |
| References: | Magn Reson Imaging. 2016 Jan;34(1):51-9. (PMID: 26435459) Age (Dordr). 2015 Oct;37(5):100. (PMID: 26378028) J Alzheimers Dis. 2010;20(1):333-41. (PMID: 20164577) Nat Rev Neurosci. 2004 Nov;5(11):863-73. (PMID: 15496864) Lancet Neurol. 2014 Oct;13(10):1045-60. (PMID: 25231526) J Neurochem. 1958 Oct;3(1):41-51. (PMID: 13611557) Neuroimage. 2010 Dec;53(4):1181-96. (PMID: 20637289) Radiology. 2010 Nov;257(2):455-62. (PMID: 20843991) PLoS One. 2018 Mar 21;13(3):e0193839. (PMID: 29561895) Neuroimage Clin. 2017 Nov 08;17:530-540. (PMID: 29201641) J Cereb Blood Flow Metab. 2014 Jan;34(1):43-51. (PMID: 24064496) Diabetes Care. 2008 Jan;31 Suppl 1:S55-60. (PMID: 18165338) Sci Rep. 2016 Oct 17;6:35514. (PMID: 27748454) Nature. 2020 May;581(7806):71-76. (PMID: 32376954) Radiology. 2020 Sep;296(3):619-626. (PMID: 32602825) J Alzheimers Dis. 2021;79(3):1203-1211. (PMID: 33427739) Neurobiol Aging. 2009 Mar;30(3):337-52. (PMID: 17869382) Am J Hum Genet. 1998 May;62(5):1198-211. (PMID: 9545414) AAPS J. 2017 Jul;19(4):921-930. (PMID: 28397097) JAMA Neurol. 2017 Jan 1;74(1):122-125. (PMID: 27893873) J Cereb Blood Flow Metab. 2019 Nov;39(11):2117-2131. (PMID: 29911470) Nutr Neurosci. 2019 May;22(5):335-343. (PMID: 29034829) Neuroepidemiology. 1994;13(6):308-13. (PMID: 7800110) J Am Coll Cardiol. 2009 Sep 29;54(14):1364-405. (PMID: 19778679) J Diabetes Res. 2020 Sep 25;2020:7242530. (PMID: 33062715) Neuropsychopharmacology. 2011 Jun;36(7):1375-84. (PMID: 21389980) Obesity (Silver Spring). 2019 Jun;27(6):932-942. (PMID: 30985999) Front Aging Neurosci. 2021 Apr 14;13:611891. (PMID: 33935681) Neurobiol Aging. 2015 Feb;36(2):925-32. (PMID: 25443291) Free Radic Biol Med. 2001 Feb 15;30(4):447-50. (PMID: 11182300) Magn Reson Med. 2014 Mar;71(3):1103-7. (PMID: 23657963) Neurobiol Dis. 2014 Feb;62:172-8. (PMID: 24121126) Front Pharmacol. 2014 Jul 08;5:165. (PMID: 25071582) Neuroimage. 2011 Jan 15;54(2):750-9. (PMID: 20923707) PLoS One. 2018 Mar 8;13(3):e0193867. (PMID: 29518107) Biometals. 2018 Oct;31(5):705-714. (PMID: 30043289) J Neurosci. 2015 Apr 29;35(17):6731-43. (PMID: 25926451) Nat Rev Neurosci. 2013 Aug;14(8):551-64. (PMID: 23820773) Neurobiol Aging. 2021 Oct;106:183-196. (PMID: 34284261) Am J Hum Genet. 1999 Aug;65(2):531-44. (PMID: 10417295) Neuroimage. 2006 Jul 1;31(3):968-80. (PMID: 16530430) J Nutr. 2011 Apr 1;141(4):729S-739S. (PMID: 21346098) Cereb Cortex. 2004 Jan;14(1):11-22. (PMID: 14654453) Neurobiol Aging. 2015 Apr;36(4):1678-1685. (PMID: 25680267) Neuro Endocrinol Lett. 2004 Oct;25(5):331-9. (PMID: 15580166) Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3834-9. (PMID: 20133720) Antioxid Redox Signal. 2014 Mar 10;20(8):1324-63. (PMID: 23815406) Sci Rep. 2016 Nov 09;6:36669. (PMID: 27827408) Neurology. 1999 Jul 13;53(1):132-9. (PMID: 10408549) Neuroimage. 2018 Oct 1;179:117-133. (PMID: 29890327) Nature. 2018 Oct;562(7726):210-216. (PMID: 30305740) Neuroimage. 2014 Jun;93 Pt 2:189-200. (PMID: 23357070) Diabetes Care. 2014 Nov;37(11):3076-83. (PMID: 25125507) Neurobiol Aging. 2016 Jul;43:149-55. (PMID: 27255824) Alzheimers Dement (Amst). 2020 Feb 07;12(1):e12002. (PMID: 32211498) Mol Psychiatry. 2020 Nov;25(11):2932-2941. (PMID: 30778133) Nat Rev Genet. 2013 Jul;14(7):507-15. (PMID: 23774735) AJNR Am J Neuroradiol. 2021 Apr;42(4):688-693. (PMID: 33509922) Neuroscience. 2017 Oct 24;362:141-151. (PMID: 28842186) Nat Commun. 2015 May 19;6:6760. (PMID: 25988319) Front Neurosci. 2021 Jan 15;14:606182. (PMID: 33519360) |
| فهرسة مساهمة: | Keywords: brain iron; genetic and environmental factors; genetic correlation; heritability; magnetic resonance imaging |
| المشرفين على المادة: | E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20220811 Date Completed: 20220913 Latest Revision: 20221117 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9467397 |
| DOI: | 10.18632/aging.204212 |
| PMID: | 35951362 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-4589 |
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| DOI: | 10.18632/aging.204212 |