دورية أكاديمية
Heritability of R2* iron in the basal ganglia and cortex.
العنوان: | Heritability of R2* iron in the basal ganglia and cortex. |
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المؤلفون: | Hofer E; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Styria, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Styria, Austria., Pirpamer L; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Styria, Austria., Langkammer C; Department of Neurology, Medical University of Graz, Styria, Austria., Tinauer C; Department of Neurology, Medical University of Graz, Styria, Austria., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA., Schmidt H; Research Unit-Genetic Epidemiology, Gottfried Schatz Research Centre for Cell Signalling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Styria, Austria., Schmidt R; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Styria, Austria. |
المصدر: | Aging [Aging (Albany NY)] 2022 Aug 09; Vol. 14 (16), pp. 6415-6426. Date of Electronic Publication: 2022 Aug 09. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
مواضيع طبية MeSH: | Basal Ganglia* , Iron*, Aged ; Brain ; Cerebral Cortex/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Middle Aged |
مستخلص: | Background: While iron is essential for normal brain functioning, elevated concentrations are commonly found in neurodegenerative diseases and are associated with impaired cognition and neurological deficits. Currently, only little is known about genetic and environmental factors that influence brain iron concentrations. Methods: Heritability and bivariate heritability of regional brain iron concentrations, assessed by R2* relaxometry at 3 Tesla MRI, were estimated with variance components models in 130 middle-aged to elderly participants of the Austrian Stroke Prevention Family Study. Results: Heritability of R2* iron ranged from 0.46 to 0.82 in basal ganglia and from 0.65 to 0.76 in cortical lobes. Age and BMI explained up to 12% and 9% of the variance of R2* iron, while APOE ε4 carrier status, hypertension, diabetes, hypercholesterolemia, sex and smoking explained 5% or less. The genetic correlation of R2* iron among basal ganglionic nuclei and among cortical lobes ranged from 0.78 to 0.87 and from 0.65 to 0.97, respectively. R2* rates in basal ganglia and cortex were not genetically correlated. Conclusions: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes. |
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فهرسة مساهمة: | Keywords: brain iron; genetic and environmental factors; genetic correlation; heritability; magnetic resonance imaging |
المشرفين على المادة: | E1UOL152H7 (Iron) |
تواريخ الأحداث: | Date Created: 20220811 Date Completed: 20220913 Latest Revision: 20221117 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC9467397 |
DOI: | 10.18632/aging.204212 |
PMID: | 35951362 |
قاعدة البيانات: | MEDLINE |
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