دورية أكاديمية
أعرض في EDS

Prokaryotic innate immunity through pattern recognition of conserved viral proteins.

التفاصيل البيبلوغرافية
العنوان: Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
المؤلفون: Gao LA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Society of Fellows, Harvard University, Cambridge, MA 02138, USA., Wilkinson ME; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Strecker J; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Makarova KS; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA., Macrae RK; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Koonin EV; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA., Zhang F; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
المصدر: Science (New York, N.Y.) [Science] 2022 Aug 12; Vol. 377 (6607), pp. eabm4096. Date of Electronic Publication: 2022 Aug 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Archaea*/immunology , Archaea*/virology , Archaeal Proteins*/chemistry , Archaeal Proteins*/classification , Archaeal Proteins*/genetics , Bacteria*/immunology , Bacteria*/virology , Bacterial Proteins*/chemistry , Bacterial Proteins*/classification , Bacterial Proteins*/genetics , Immunity, Innate* , NLR Proteins*/chemistry , NLR Proteins*/genetics , Receptors, Pattern Recognition*/chemistry , Receptors, Pattern Recognition*/classification , Receptors, Pattern Recognition*/genetics , Viral Proteins*/chemistry , Viral Proteins*/genetics, Animals ; Bacteriophages ; Cryoelectron Microscopy ; Phylogeny
مستخلص: Many organisms have evolved specialized immune pattern-recognition receptors, including nucleotide-binding oligomerization domain-like receptors (NLRs) of the STAND superfamily that are ubiquitous in plants, animals, and fungi. Although the roles of NLRs in eukaryotic immunity are well established, it is unknown whether prokaryotes use similar defense mechanisms. Here, we show that antiviral STAND (Avs) homologs in bacteria and archaea detect hallmark viral proteins, triggering Avs tetramerization and the activation of diverse N-terminal effector domains, including DNA endonucleases, to abrogate infection. Cryo-electron microscopy reveals that Avs sensor domains recognize conserved folds, active-site residues, and enzyme ligands, allowing a single Avs receptor to detect a wide variety of viruses. These findings extend the paradigm of pattern recognition of pathogen-specific proteins across all three domains of life.
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معلومات مُعتمدة: DP1 HL141201 United States HL NHLBI NIH HHS; R01 HG009761 United States HG NHGRI NIH HHS; United States HHMI Howard Hughes Medical Institute
المشرفين على المادة: 0 (Archaeal Proteins)
0 (Bacterial Proteins)
0 (NLR Proteins)
0 (Receptors, Pattern Recognition)
0 (Viral Proteins)
تواريخ الأحداث: Date Created: 20220811 Date Completed: 20220815 Latest Revision: 20230322
رمز التحديث: 20230322
مُعرف محوري في PubMed: PMC10028730
DOI: 10.1126/science.abm4096
PMID: 35951700
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.abm4096