دورية أكاديمية
أعرض في EDS

Restructured membrane contacts rewire organelles for human cytomegalovirus infection.

التفاصيل البيبلوغرافية
العنوان: Restructured membrane contacts rewire organelles for human cytomegalovirus infection.
المؤلفون: Cook KC; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, US., Tsopurashvili E; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, US., Needham JM; Department of Microbiology, University of Alabama Birmingham, Birmingham, AL, 35294, US., Thompson SR; Department of Microbiology, University of Alabama Birmingham, Birmingham, AL, 35294, US., Cristea IM; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, US. icristea@princeton.edu.
المصدر: Nature communications [Nat Commun] 2022 Aug 11; Vol. 13 (1), pp. 4720. Date of Electronic Publication: 2022 Aug 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Cytomegalovirus Infections* , Herpes Simplex* , Herpesviridae Infections*/metabolism , Viruses*, Cytomegalovirus/physiology ; Humans ; Organelles ; Peroxisomes/metabolism
مستخلص: Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space and time. Although viruses remodel organelles for their replication cycles, MCSs remain largely unexplored during infections. Here, we design a targeted proteomics platform for measuring MCS proteins at all organelles simultaneously and define functional virus-driven MCS alterations by the ancient beta-herpesvirus human cytomegalovirus (HCMV). Integration with super-resolution microscopy and comparisons to herpes simplex virus (HSV-1), Influenza A, and beta-coronavirus HCoV-OC43 infections reveals time-sensitive contact regulation that allows switching anti- to pro-viral organelle functions. We uncover a stabilized mitochondria-ER encapsulation structure (MENC). As HCMV infection progresses, MENCs become the predominant mitochondria-ER contact phenotype and sequentially recruit the tethering partners VAP-B and PTPIP51, supporting virus production. However, premature ER-mitochondria tethering activates STING and interferon response, priming cells against infection. At peroxisomes, ACBD5-mediated ER contacts balance peroxisome proliferation versus membrane expansion, with ACBD5 impacting the titers of each virus tested.
(© 2022. The Author(s).)
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معلومات مُعتمدة: R01 AI174515 United States AI NIAID NIH HHS; T32 GM008111 United States GM NIGMS NIH HHS; T32 GM007388 United States GM NIGMS NIH HHS; F31 AI147637 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20220811 Date Completed: 20220815 Latest Revision: 20231020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9366835
DOI: 10.1038/s41467-022-32488-6
PMID: 35953480
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-32488-6