دورية أكاديمية
Correlation Between CD133+ Stem Cells and Clinical Improvement in Patients with Autism Spectrum Disorders Treated with Intrathecal Bone Marrow-derived Mononuclear Cells.
| العنوان: | Correlation Between CD133+ Stem Cells and Clinical Improvement in Patients with Autism Spectrum Disorders Treated with Intrathecal Bone Marrow-derived Mononuclear Cells. |
|---|---|
| المؤلفون: | Villarreal-Martinez L; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., MartÍnez-Garza LE; Drs. Martínez-Garza and Rodriguez-Sanchez are with the Genetics Department, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Rodriguez-Sanchez IP; Drs. Martínez-Garza and Rodriguez-Sanchez are with the Genetics Department, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Alvarez-Villalobos N; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Guzman-Gallardo F; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Pope-Salazar S; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Salinas-Silva C; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Cepeda-Cepeda MG; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Garza-Bedolla A; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Dominguez-Varela IA; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Villarreal-Martinez DZ; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Treviño-Villarreal JH; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico., Gomez-Almaguer D; Drs. L Villarreal-Martinez, Alvarez-Villalobos, Guzman-Gallardo, Pope-Salazar, Salinas-Silva, Cepeda-Cepeda, Garza-Bedolla, Dominguez-Varela, DZ Villarreal-Martinez, Treviño-Villarreal, and Gomez-Almaguer are with Hematology Service, Hospital Universitario 'Dr. José Eleuterio González' in Monterrey, Mexico. |
| المصدر: | Innovations in clinical neuroscience [Innov Clin Neurosci] 2022 Apr-Jun; Vol. 19 (4-6), pp. 78-86. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Matrix Medical Communications Country of Publication: United States NLM ID: 101549695 Publication Model: Print Cited Medium: Print ISSN: 2158-8333 (Print) Linking ISSN: 21588333 NLM ISO Abbreviation: Innov Clin Neurosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: West Chester, Pennsylvania : Matrix Medical Communications Original Publication: [Edgemont, Pa.] : [Matrix Medical Communications], [2011]- |
| مستخلص: | Autism spectrum disorders (ASDs) are a group of neurodevelopmental pathologies characterized by social and communication deficits, for which treatments are limited. Cell therapies, including intrathecal (IT) administration of bone marrow (BM) mononuclear cells (BM-MNC), improves symptoms in patients with ASD. Twenty-four patients diagnosed with ASD, according to the Diagnostic and Statistical Manual of Mental Disorders Text Revision Fourth Edition (DSM-IV-TR) criteria, were autologously treated with IT BM-MNC, and the clinical effect was evaluated using the Childhood Autism Rating Scale (CARS) on Days 30 (n=24) and 180 (n=14) post-treatment. IT BM-MNC improved clinical outcomes by Day 30 ( p =0.0039), and those benefits remained and were further accentuated by Day 180 post-treatment (n=14; p =<0.0001). Clinical benefit at Days 30 ( p =0.001; r= -0.51) and 180 ( p =0.01; r= -0.60) posttreatment positively correlated with the enrichment of a putative BM stem cell population expressing the cluster of differentiation 133+ (CD133+) surface marker. Competing Interests: DISCLOSURES: All authors are employees of Hospital Universitario “Dr. José Eleuterio González.” (Copyright © 2022. Matrix Medical Communications. All rights reserved.) |
| References: | Neurosurgery. 2011 Mar;68(3):588-600. (PMID: 21192274) Cochrane Database Syst Rev. 2018 Jul 24;7:CD009044. (PMID: 30075057) Lancet. 2014 Mar 8;383(9920):896-910. (PMID: 24074734) Pediatr Crit Care Med. 2015 Mar;16(3):245-55. (PMID: 25581630) Brain Res. 2005 Feb 21;1035(1):73-85. (PMID: 15713279) Acta Neuropathol. 2017 Oct;134(4):537-566. (PMID: 28584888) Pharmaceuticals (Basel). 2018 Jun 04;11(2):. (PMID: 29867038) Neurotherapeutics. 2015 Jul;12(3):521-33. (PMID: 26036957) Stem Cell Res Ther. 2019 Jun 21;10(1):182. (PMID: 31227011) CNS Neurol Disord Drug Targets. 2018;17(8):590-594. (PMID: 29984672) Exp Neurol. 2005 Feb;191(2):344-60. (PMID: 15649491) PLoS One. 2013 Apr 24;8(4):e62189. (PMID: 23638000) Ann N Y Acad Sci. 2016 Apr;1370(1):109-18. (PMID: 27270495) Asia Pac Psychiatry. 2021 Jun;13(2):e12445. (PMID: 33150703) Cochrane Database Syst Rev. 2019 Jan 30;1:CD009768. (PMID: 30697701) J Cell Sci. 2004 Sep 1;117(Pt 19):4411-22. (PMID: 15304527) Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3908-13. (PMID: 9520466) Brain Behav. 2016 Aug 03;6(10):e00526. (PMID: 27781140) Stem Cell Res. 2013 Jul;11(1):625-33. (PMID: 23651585) Expert Opin Pharmacother. 2009 Sep;10(13):2127-43. (PMID: 19640207) Stem Cells. 2017 Apr;35(4):1065-1079. (PMID: 27800660) Stem Cell Res Ther. 2013 Jan 06;4(1):3. (PMID: 23290300) Am J Hum Genet. 2014 May 1;94(5):677-94. (PMID: 24768552) Eur J Pharmacol. 2016 May 5;778:96-102. (PMID: 25941080) Mol Psychiatry. 2015 Mar;20(3):369-76. (PMID: 24888361) Rev Neurosci. 2014;25(6):841-50. (PMID: 25222596) Public Health Rev. 2012;34(2):1-22. (PMID: 26236074) Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18117-22. (PMID: 15608062) Mol Neurobiol. 2020 May;57(5):2279-2289. (PMID: 32008165) Stem Cells Int. 2013;2013:623875. (PMID: 24062774) Nat Commun. 2019 Mar 4;10(1):1022. (PMID: 30833582) N Engl J Med. 2014 Mar 27;370(13):1209-1219. (PMID: 24670167) Stem Cells Transl Med. 2016 Nov;5(11):1538-1549. (PMID: 27400795) Behav Brain Res. 2017 Jan 15;317:479-484. (PMID: 27717813) Nat Rev Nephrol. 2018 Aug;14(8):493-507. (PMID: 29895977) J Transl Med. 2013 Aug 27;11:196. (PMID: 23978163) Behav Brain Res. 2017 Jul 28;331:254-260. (PMID: 28392323) Front Bioeng Biotechnol. 2018 Jul 24;6:93. (PMID: 30087891) J Nippon Med Sch. 2015;82(2):92-9. (PMID: 25959200) Ann Hematol. 2011 Feb;90(2):127-37. (PMID: 20821012) Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10711-6. (PMID: 10485891) Brain Res. 2004 Dec 24;1030(1):19-27. (PMID: 15567334) Stem Cells. 2005 Aug;23(7):879-94. (PMID: 15888687) J Autism Dev Disord. 2016 Jan;46(1):42-52. (PMID: 26210516) Science. 2019 May 17;364(6441):685-689. (PMID: 31097668) Nat Commun. 2020 Sep 25;11(1):4873. (PMID: 32978376) Haematologica. 2018 Oct;103(10):1604-1615. (PMID: 29858385) Blood. 2006 Mar 1;107(5):2162-9. (PMID: 16269619) J Hematother Stem Cell Res. 2001 Apr;10(2):273-81. (PMID: 11359674) Am J Stem Cells. 2020 Dec 25;9(5):89-100. (PMID: 33489466) Genes Brain Behav. 2008 Mar;7(2):152-63. (PMID: 17559418) Nat Immunol. 2002 Jul;3(7):687-94. (PMID: 12068293) JAMA. 2010 Feb 17;303(7):602. (PMID: 20159865) Adv Exp Med Biol. 2013;777:99-111. (PMID: 23161078) |
| فهرسة مساهمة: | Keywords: Asperger’s syndrome; Autism; Rett’s disorder; childhood disintegrate disorder; stem cells |
| تواريخ الأحداث: | Date Created: 20220812 Latest Revision: 20220813 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9341312 |
| PMID: | 35958968 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2158-8333 |
|---|