دورية أكاديمية
أعرض في EDS

Pancreatic exocrine insufficiency following pancreatoduodenectomy: A prospective bi-center study.

التفاصيل البيبلوغرافية
العنوان: Pancreatic exocrine insufficiency following pancreatoduodenectomy: A prospective bi-center study.
المؤلفون: Kroon VJ; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Daamen LA; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands; Dept. of Radiation Oncology, UMC Utrecht Cancer Center, Utrecht University, Utrecht, the Netherlands., Tseng DSJ; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., de Vreugd AR; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Brada LJH; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Busch OR; Dept. of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, the Netherlands., Derksen TC; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Gerritsen A; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Rombouts SJE; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Smits FJ; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Walma MS; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Wennink RAW; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Besselink MG; Dept. of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, the Netherlands., van Santvoort HC; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands., Molenaar IQ; Dept. of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, the Netherlands. Electronic address: I.Q.Molenaar@umcutrecht.nl.
المصدر: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2022 Nov; Vol. 22 (7), pp. 1020-1027. Date of Electronic Publication: 2022 Aug 05.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Country of Publication: Switzerland NLM ID: 100966936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1424-3911 (Electronic) Linking ISSN: 14243903 NLM ISO Abbreviation: Pancreatology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : New Delhi : Elsevier India
Original Publication: Basel ; New York : Karger, c2001-
مواضيع طبية MeSH: Pancreaticoduodenectomy*/adverse effects , Exocrine Pancreatic Insufficiency*/epidemiology , Exocrine Pancreatic Insufficiency*/etiology , Exocrine Pancreatic Insufficiency*/diagnosis, Humans ; Prospective Studies ; Pancreas ; Vitamin A
مستخلص: Background/objectives: Pancreatic exocrine insufficiency (PEI) is a common complication following pancreatoduodenectomy (PD) leading to malnutrition. The course of PEI and related symptoms and vitamin deficiencies is unknown. This study aimed to assess the (long-term) incidence of PEI and vitamin deficiencies after PD.
Methods: A bi-centre prospective observational cohort study was performed, including patients who underwent PD for mainly pancreatic and periampullary (pre)malignancies (2014-2018). Two cohorts were formed to evaluate short and long-term results. Patients were followed for 18 months and clinical symptoms were evaluated by questionnaire. PEI was based on faecal elastase-1 (FE-1) levels and/or clinical symptoms.
Results: In total, 95 patients were included. After three months, all but three patients had developed PEI and 27/29 (93%) patients of whom stool samples were available showed abnormal FE-1 levels, which did not improve during follow-up. After six months, all patients had developed PEI. During follow-up, symptoms resolved in 35%-70% of patients. Vitamin D and K deficiencies were observed in 48%-79% of patients, depending on the moment of follow-up; 0%-50% of the patients with deficiencies received vitamin supplementation.
Discussion: This prospective study found a high incidence of PEI after PD with persisting symptoms in one-to two thirds of all patients. Limited attention was paid to vitamin deficiencies. Improved screening and treatment strategies for PEI and vitamins need to be designed.
Competing Interests: Declaration of competing interest None.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Pancreatic exocrine insufficiency; pancreatic cancer; pancreatic enzyme replacement therapy; pancreatic surgery
المشرفين على المادة: 11103-57-4 (Vitamin A)
تواريخ الأحداث: Date Created: 20220812 Date Completed: 20221115 Latest Revision: 20221115
رمز التحديث: 20221213
DOI: 10.1016/j.pan.2022.08.002
PMID: 35961936
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-3911
DOI:10.1016/j.pan.2022.08.002