دورية أكاديمية
Heart rate variability and atrial fibrillation in the general population: a longitudinal and Mendelian randomization study.
| العنوان: | Heart rate variability and atrial fibrillation in the general population: a longitudinal and Mendelian randomization study. |
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| المؤلفون: | Geurts S; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Tilly MJ; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Arshi B; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Stricker BHC; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Kors JA; Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Deckers JW; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., de Groot NMS; Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. m.kavousi@erasmusmc.nl. |
| المصدر: | Clinical research in cardiology : official journal of the German Cardiac Society [Clin Res Cardiol] 2023 Jun; Vol. 112 (6), pp. 747-758. Date of Electronic Publication: 2022 Aug 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Country of Publication: Germany NLM ID: 101264123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-0692 (Electronic) Linking ISSN: 18610684 NLM ISO Abbreviation: Clin Res Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Aug. 2007- : Heidelberg, Germany : Springer Medizin Original Publication: Darmstadt, Germany : Springer Medizin, [2006]- |
| مواضيع طبية MeSH: | Atrial Fibrillation*/epidemiology , Atrial Fibrillation*/genetics, Female ; Humans ; Male ; Middle Aged ; Genome-Wide Association Study ; Heart Rate/physiology ; Mendelian Randomization Analysis ; Longitudinal Studies |
| مستخلص: | Background: Sex differences and causality of the association between heart rate variability (HRV) and atrial fibrillation (AF) in the general population remain unclear. Methods: 12,334 participants free of AF from the population-based Rotterdam Study were included. Measures of HRV including the standard deviation of normal RR intervals (SDNN), SDNN corrected for heart rate (SDNNc), RR interval differences (RMSSD), RMSSD corrected for heart rate (RMSSDc), and heart rate were assessed at baseline and follow-up examinations. Joint models, adjusted for cardiovascular risk factors, were used to determine the association between longitudinal measures of HRV with new-onset AF. Genetic variants for HRV were used as instrumental variables in a Mendelian randomization (MR) analysis using genome-wide association studies (GWAS) summary-level data. Results: During a median follow-up of 9.4 years, 1302 incident AF cases occurred among 12,334 participants (mean age 64.8 years, 58.3% women). In joint models, higher SDNN (fully-adjusted hazard ratio (HR), 95% confidence interval (CI) 1.24, 1.04-1.47, p = 0.0213), and higher RMSSD (fully-adjusted HR, 95% CI 1.33, 1.13-1.54, p = 0.0010) were significantly associated with new-onset AF. Sex-stratified analyses showed that the associations were mostly prominent among women. In MR analyses, a genetically determined increase in SDNN (odds ratio (OR), 95% CI 1.60, 1.27-2.02, p = 8.36 × 10 -05 ), and RMSSD (OR, 95% CI 1.56, 1.31-1.86, p = 6.32 × 10 -07 ) were significantly associated with an increased odds of AF. Conclusion: Longitudinal measures of uncorrected HRV were significantly associated with new-onset AF, especially among women. MR analyses supported the causal relationship between uncorrected measures of HRV with AF. Our findings indicate that measures to modulate HRV might prevent AF in the general population, in particular in women. AF; atrial fibrillation, GWAS; genome-wide association study, IVW; inverse variance weighted, MR; Mendelian randomization, MR-PRESSO; MR-egger and mendelian randomization pleiotropy residual sum and outlier, RMSSD; root mean square of successive RR interval differences, RMSSDc; root mean square of successive RR interval differences corrected for heart rate, SDNN; standard deviation of normal to normal RR intervals, SDNNc; standard deviation of normal to normal RR intervals corrected for heart rate, WME; weighted median estimator. a Rotterdam Study n=12,334 b HRV GWAS n=53,174 c AF GWAS n=1,030,836. (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | MC_PC_17228 United Kingdom MRC_ Medical Research Council; MC_QA137853 United Kingdom MRC_ Medical Research Council; 03-004-2021-T050 Hartstichting |
| فهرسة مساهمة: | Keywords: Atrial fibrillation; Epidemiology; Heart rate variability; Mendelian randomization; Risk factors; Sex differences |
| تواريخ الأحداث: | Date Created: 20220813 Date Completed: 20230609 Latest Revision: 20230703 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10241681 |
| DOI: | 10.1007/s00392-022-02072-5 |
| PMID: | 35962833 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1861-0692 |
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| DOI: | 10.1007/s00392-022-02072-5 |