دورية أكاديمية
Anti-hyperglycemic effects of propolis or metformin in type 2 diabetes mellitus.
| العنوان: | Anti-hyperglycemic effects of propolis or metformin in type 2 diabetes mellitus. |
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| المؤلفون: | Ochoa-Morales PD; Instituto de Terapéutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico., González-Ortiz M; Instituto de Terapéutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico.; Centro de Investigación Biomédica para la Salud, SA de CV, Guadalajara, Mexico., Martínez-Abundis E; Instituto de Terapéutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico.; Centro de Investigación Biomédica para la Salud, SA de CV, Guadalajara, Mexico., Pérez-Rubio KG; Instituto de Terapéutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico.; Centro de Investigación Biomédica para la Salud, SA de CV, Guadalajara, Mexico., Patiño-Laguna ADJ; Instituto de Terapéutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico. |
| المصدر: | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition [Int J Vitam Nutr Res] 2023 Dec; Vol. 93 (6), pp. 498-506. Date of Electronic Publication: 2022 Aug 15. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hans Huber Country of Publication: Switzerland NLM ID: 1273304 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0300-9831 (Print) Linking ISSN: 03009831 NLM ISO Abbreviation: Int J Vitam Nutr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bern : Hans Huber |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/drug therapy , Metformin*/therapeutic use , Metformin*/pharmacology , Propolis*/therapeutic use , Insulin Resistance*, Humans ; Glycated Hemoglobin ; Blood Glucose/metabolism ; Insulin/metabolism ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Double-Blind Method |
| مستخلص: | Background: The aim of this study was to evaluate the effect of propolis or metformin versus placebo on glycemic control in pharmacological treatment-naïve patients with type 2 diabetes mellitus (T2DM). Methods: A double-blind, randomized, placebo-controlled in parallel groups clinical trial was performed in 36 pharmacological treatment-naïve patients with T2DM. They received propolis (300 mg), metformin (850 mg), or placebo twice daily before breakfast and dinner for 12 weeks. At the beginning and end of the study, fasting plasma glucose (FPG), 2-h postload glucose (2-h PG) during a 75-g oral glucose tolerance test, glycated hemoglobin A1c (A1C) and a metabolic profile were measured. Areas under the curve (AUC) of glucose and insulin, total insulin secretion (insulinogenic index), the first phase of insulin secretion (Stumvoll index), and insulin sensitivity (Matsuda index) were calculated. Statistical analyses: Kruskal-Wallis, Mann-Whitney U and Wilcoxon tests. Results: The propolis and metformin groups exhibited significant reductions in FPG (p=0.009 and p=0.001, respectively), 2-h PG (p=0.034 and p=0.001, respectively) levels, AUC of insulin, Stumvoll index, and an increment in the Matsuda index. The comparison of the changes from baseline to the end showed significant differences between placebo and propolis in FPG (p=0.004) and A1C (p=0.049) levels, while between placebo and metformin were in FPG (p=0.002), 2-h PG (p=0.004) and A1C (p=0.007) levels. Conclusions: The administration of propolis and metformin compared to placebo reduced FPG and A1C levels; in addition, metformin decreased 2-h PG, AUC of glucose and insulin, high-density lipoprotein cholesterol, and increased the insulin sensitivity. |
| فهرسة مساهمة: | Keywords: Propolis; glycemic control; metformin; pharmacological treatment-naïve patients; type 2 diabetes mellitus |
| المشرفين على المادة: | 9100L32L2N (Metformin) 9009-62-5 (Propolis) 0 (Glycated Hemoglobin) 0 (Blood Glucose) 0 (Insulin) 0 (Hypoglycemic Agents) |
| تواريخ الأحداث: | Date Created: 20220815 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1024/0300-9831/a000760 |
| PMID: | 35965421 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-9831 |
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| DOI: | 10.1024/0300-9831/a000760 |