دورية أكاديمية
SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer.
| العنوان: | SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer. |
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| المؤلفون: | Xie SY; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China.; Department of Radiation Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou, Guangdong, China., Shi DB; Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou, Guangdong, China., Ouyang Y; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China., Lin F; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China., Chen XY; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China., Jiang TC; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China., Xia W; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China., Guo L; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China., Lin HX; Department of Radiotherapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China. |
| المصدر: | American journal of cancer research [Am J Cancer Res] 2022 Jul 15; Vol. 12 (7), pp. 3405-3421. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101549944 Publication Model: eCollection Cited Medium: Print ISSN: 2156-6976 (Print) Linking ISSN: 21566976 NLM ISO Abbreviation: Am J Cancer Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Madison, WI : e-Century Pub. Corp., [2011]- |
| مستخلص: | Cancer cells modulate their metabolic activities to adapt to their growth and proliferation. Despite advances in breast cancer biology having led to the widespread use of molecular targeted therapy and hormonal drugs, the molecular mechanisms in metabolism related to the regulation of breast cancer cell proliferation are still poorly understood. Here, we investigate the possible role of SHMT2, a key enzyme in serine metabolism, in breast cancer. Firstly, SHMT2 is found highly expressed in both breast cancer cells and tissues, and patients with high expression of SHMT2 have a worse prognosis. Moreover, the intervention of SHMT2 by either knockdown or over-expression in vitro induces the effect on breast cancer proliferation. Mechanistically, RNA-seq shows that over-expression of SHMT2 affect multiple signaling pathways and biological process in breast cancer cells. Furthermore, we confirm that SHMT2 promotes breast cancer cell growth through MAPK and VEGF signaling pathways. Finally, we verify the role of SHMT2 in promoting breast cancer growth in the xenograft tumor model. Our results indicate that SHMT2 plays a critical role in regulating breast cancer growth through MAPK, and VEGF signaling pathways, and maybe serve as a therapeutic target for breast cancer therapy. Competing Interests: None. (AJCR Copyright © 2022.) |
| References: | Int J Biol Macromol. 2019 Sep 1;136:1237-1246. (PMID: 31252007) Cell. 2011 Mar 4;144(5):646-74. (PMID: 21376230) Cells. 2019 Sep 06;8(9):. (PMID: 31500219) Am J Transl Res. 2019 Apr 15;11(4):2140-2154. (PMID: 31105824) Cells. 2020 Aug 06;9(8):. (PMID: 32781794) Oncol Lett. 2018 Jan;15(1):1072-1078. (PMID: 29391897) J Agric Food Chem. 2018 Dec 12;66(49):12953-12960. (PMID: 30511573) Med Sci Monit. 2019 Aug 05;25:5823-5832. (PMID: 31379360) J Clin Invest. 2021 Aug 2;131(15):. (PMID: 34166228) Protein Cell. 2014 Oct;5(10):737-49. (PMID: 25073422) Cancers (Basel). 2020 Apr 08;12(4):. (PMID: 32276534) Oncol Rep. 2016 Nov;36(5):2489-2500. (PMID: 27666119) Arch Biochem Biophys. 2018 Sep 1;653:71-79. (PMID: 29991441) Biomed Res Int. 2019 Nov 18;2019:2712185. (PMID: 31828098) J Immunol Res. 2021 Apr 8;2021:6647122. (PMID: 33928169) Oncogene. 2021 Jan;40(4):777-790. (PMID: 33262463) Cell Rep. 2016 Jan 26;14(3):506-519. (PMID: 26774480) Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19345-50. (PMID: 18032601) Transplantation. 2019 Jul;103(7):e188-e197. (PMID: 30964837) Invest New Drugs. 2021 Dec;39(6):1671-1681. (PMID: 34215932) J Cancer. 2021 Aug 8;12(19):5888-5894. (PMID: 34476002) Nature. 2015 Apr 16;520(7547):363-7. (PMID: 25855294) Am J Cancer Res. 2021 Aug 15;11(8):3777-3793. (PMID: 34522449) Nat Genet. 2015 Dec;47(12):1475-81. (PMID: 26482881) Nat Rev Cancer. 2013 Apr;13(4):258-71. (PMID: 23486238) PLoS One. 2012;7(8):e43898. (PMID: 22952803) Aging Cell. 2015 Oct;14(5):826-37. (PMID: 26103880) J Biol Chem. 1993 Jun 5;268(16):11910-6. (PMID: 8505317) Curr Opin Pharmacol. 2016 Dec;31:97-103. (PMID: 27883943) Oncogene. 2021 Feb;40(5):964-979. (PMID: 33299122) Cancer Discov. 2014 Dec;4(12):1406-17. (PMID: 25186948) Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173) Clin Transl Oncol. 2019 Sep;21(9):1250-1259. (PMID: 30788837) Nat Commun. 2020 May 15;11(1):2416. (PMID: 32415208) Sci Adv. 2016 May 27;2(5):e1600200. (PMID: 27386546) Science. 1956 Feb 24;123(3191):309-14. (PMID: 13298683) |
| فهرسة مساهمة: | Keywords: MAPK; SHMT2; VEGF; breast cancer; serine/glycine metabolism |
| تواريخ الأحداث: | Date Created: 20220815 Latest Revision: 20220816 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9360240 |
| PMID: | 35968337 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2156-6976 |
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