دورية أكاديمية
Stakeholders' views and perspectives on treatments of visceral leishmaniasis and their outcomes in HIV-coinfected patients in East Africa and South-East Asia: A mixed methods study.
| العنوان: | Stakeholders' views and perspectives on treatments of visceral leishmaniasis and their outcomes in HIV-coinfected patients in East Africa and South-East Asia: A mixed methods study. |
|---|---|
| المؤلفون: | Khabsa J; Clinical Research Institute, American University of Beirut Medical Center, Beirut, Lebanon., Jain S; Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland., El-Harakeh A; Clinical Research Institute, American University of Beirut Medical Center, Beirut, Lebanon., Rizkallah C; Hariri School of Nursing, American University of Beirut, Beirut, Lebanon., Pandey DK; Kala-azar Elimination Programme, World Health Organization Country Office, New Delhi, India., Manaye N; Neglected Tropical Diseases, World Health Organization Country Office, Addis Ababa, Ethiopia., Honein-AbouHaidar G; Hariri School of Nursing, American University of Beirut, Beirut, Lebanon., Halleux C; Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland., Dagne DA; Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland., Akl EA; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. |
| المصدر: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Aug 15; Vol. 16 (8), pp. e0010624. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Antiprotozoal Agents*/therapeutic use , Coinfection* , HIV Infections*/complications , HIV Infections*/drug therapy , Leishmaniasis, Visceral*/complications , Leishmaniasis, Visceral*/drug therapy, Africa, Eastern ; Asia, Eastern ; Humans |
| مستخلص: | Background: In visceral leishmaniasis (VL) patients coinfected with human immunodeficiency virus (HIV), combination therapy (liposomal amphotericin B infusion and oral miltefosine) is being considered as an alternative to liposomal amphotericin B monotherapy. We aimed to assess the views of stakeholders in relation to these treatment options. Methodology: In a mixed methods study, we surveyed and interviewed patients, government functionaries, programme managers, health service providers, nongovernmental organizations, researchers, and World Health Organization (WHO) personnel. We used the Evidence to Decision (EtD) framework for data collection planning and analysis. Constructs of interest included valuation of outcomes, impact on equity, feasibility and acceptability of the treatment options, implementation considerations, monitoring and evaluation, and research priorities. Principal Findings/conclusion: Mortality and non-serious adverse events were rated as "critical" by respectively the highest (61%) and lowest percentages (47%) of survey participants. Participants viewed clinical cure as essential for patients to regain productivity. Non-patient stakeholders emphasized the importance of "sustained" clinical cure. For most survey participants, combination therapy, compared with monotherapy, would increase health equity (40%), and be more acceptable (79%) and feasible (57%). Interviews revealed that combination therapy was more feasible and acceptable than monotherapy when associated with a shorter duration of hospitalization. The findings of the interviews provided insight into those of the survey. When choosing between alternative options, providers should consider the outcomes that matter to patients as well as the impact on equity, feasibility, and acceptability of the options. Competing Interests: The authors have declared that no competing interests exist. |
| References: | Hum Resour Health. 2019 Feb 18;17(1):13. (PMID: 30777095) Eur Respir J. 2018 Jul 19;52(1):. (PMID: 30002103) BMC Med Res Methodol. 2013 Sep 18;13:117. (PMID: 24047204) J Health Serv Res Policy. 2008 Apr;13(2):92-8. (PMID: 18416914) Hum Resour Health. 2020 Oct 16;18(1):77. (PMID: 33066792) Health Qual Life Outcomes. 2016 Jan 08;14:2. (PMID: 26746197) PLoS Negl Trop Dis. 2019 Jan 17;13(1):e0006988. (PMID: 30653490) Am J Trop Med Hyg. 2018 Mar;98(3):747-752. (PMID: 29363454) BMJ. 2016 Jun 30;353:i2089. (PMID: 27365494) PLoS One. 2020 Feb 10;15(2):e0227911. (PMID: 32040525) Clin Infect Dis. 2022 Feb 11;:. (PMID: 35147680) J Clin Epidemiol. 2021 Jan;129:40-50. (PMID: 32987160) J Rheumatol. 2020 Feb;47(2):176-187. (PMID: 30988125) World Health Organ Tech Rep Ser. 2010;(949):xii-xiii, 1-186, back cover. (PMID: 21485694) BMJ. 2016 Jun 28;353:i2016. (PMID: 27353417) Obes Surg. 2016 Nov;26(11):2738-2746. (PMID: 27138600) Health Serv Res. 2013 Dec;48(6 Pt 2):2134-56. (PMID: 24279835) |
| معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
| المشرفين على المادة: | 0 (Antiprotozoal Agents) |
| تواريخ الأحداث: | Date Created: 20220815 Date Completed: 20220829 Latest Revision: 20221207 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9410553 |
| DOI: | 10.1371/journal.pntd.0010624 |
| PMID: | 35969636 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1935-2735 |
|---|---|
| DOI: | 10.1371/journal.pntd.0010624 |