دورية أكاديمية
Stability of valeriana-type iridoid glycosides from rhizomes of Nardostachys jatamansi and their protection against H 2 O 2 -induced oxidative stress in SH-SY5Y cells.
| العنوان: | Stability of valeriana-type iridoid glycosides from rhizomes of Nardostachys jatamansi and their protection against H |
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| المؤلفون: | Ngo TH; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea. Electronic address: trunghuyngo95@gmail.com., Uprety A; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea., Ojha M; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea., Kil YS; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea., Choi H; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea., Kim SY; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea. Electronic address: sooykim@yu.ac.kr., Nam JW; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 38541, South Korea. Electronic address: jwnam@yu.ac.kr. |
| المصدر: | Phytochemistry [Phytochemistry] 2022 Nov; Vol. 203, pp. 113375. Date of Electronic Publication: 2022 Aug 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| مواضيع طبية MeSH: | Biological Products* , Nardostachys* , Neuroblastoma* , Valerian*/chemistry, Humans ; Hydrogen/analysis ; Hydrogen Peroxide/analysis ; Iridoid Glycosides/pharmacology ; Iridoids/chemistry ; Oxidative Stress ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Rhizome ; Solvents |
| مستخلص: | Nardostachys jatamansi is close to Valerian in consideration of their same psychoactive effects, such as sedation and neuroprotection. Valeriana-type iridoids are major active components of Valerian, but few valeriana-type iridoids have been isolated from N. jatamansi. Iridoid-targeting chemical investigation of the rhizomes of N. jatamansi resulted in the isolation of seven valeriana-type iridoid glycosides, four of which are previously undescribed. Their structures were determined through NMR spectroscopy, high-resolution mass spectrometry, and optical rotation experiments. In addition, the inaccurate configurations of patrinalloside and 6″-acetylpatrinalloside from previous reports were corrected. These compounds, unstable due to alcoholic solvents, were more stable in the mixtures than in purified forms, as monitored by the qNMR method, supporting the use of natural products as mixtures. Furthermore, the isolates, as well as crude and solvent partition extracts, were found to have a protective effect against hydrogen-peroxide-induced toxicity in human neuroblastoma cells, as confirmed by assays for cell viability and antioxidation. These findings suggest the potential therapeutic application of the valeriana-type iridoid glycosides isolated herein with improved biochemical stability. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Caprifoliaceae; Nardostachys jatamansi (D.Don) DC.; Oxidative stress; SH-SY5Y cells; Stability; Valeriana-type iridoid glycosides; qNMR |
| المشرفين على المادة: | 0 (Biological Products) 0 (Iridoid Glycosides) 0 (Iridoids) 0 (Plant Extracts) 0 (Solvents) 7YNJ3PO35Z (Hydrogen) BBX060AN9V (Hydrogen Peroxide) |
| تواريخ الأحداث: | Date Created: 20220816 Date Completed: 20221010 Latest Revision: 20221011 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.phytochem.2022.113375 |
| PMID: | 35973611 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3700 |
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| DOI: | 10.1016/j.phytochem.2022.113375 |