تقرير
The effect of nigella supplementation on blood pressure: A systematic review and dose-response meta-analysis.
| العنوان: | The effect of nigella supplementation on blood pressure: A systematic review and dose-response meta-analysis. |
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| المؤلفون: | Golpour-Hamedani S; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Hadi A; Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran., SafariMalekabadi D; Department of Nutrition, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran., Najafgholizadeh A; Department of Microbiology, Naein Branch, Islamic Azad University, Isfahan, Iran., Askari G; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Pourmasoumi M; Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. |
| المصدر: | Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2024; Vol. 64 (4), pp. 943-956. Date of Electronic Publication: 2022 Aug 17. |
| نوع المنشور: | Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 8914818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-7852 (Electronic) Linking ISSN: 10408398 NLM ISO Abbreviation: Crit Rev Food Sci Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : Taylor & Francis Group Original Publication: Boca Raton, Fla. : CRC Press, c1980- |
| مواضيع طبية MeSH: | Blood Pressure* , Dietary Supplements* , Nigella*, Adult ; Humans ; Hypertension |
| مستخلص: | This study was performed to assess the effect of nigella supplementation on blood pressure levels among the adult population. A comprehensive search was carried out through PubMed, Scopus, Web of Science, and Cochrane Library by using relevant keywords to find out the randomized clinical trials evaluating the effect of nigella administration on systolic blood pressure (SBP) and diastolic blood pressure (DBP). A random-effect model was applied to achieve the overall effect size. Subgroup analysis and meta-regression were used to explore the source of heterogeneity and the effects of the possible moderators. Of the twenty-two trials that were eligible for the present study, seventeen studies consisting of 1048 participants were included in the meta-analysis. The results indicated that nigella administration could significantly reduce both SBP (-4.58 mmHg; 95%CI: -6.22, -2.94) and DBP (-3.08 mmHg; 95%CI: -4.62, -1.55). Subgroup analysis did not show any superiority between subgroups of variables. Dose-response analysis detected a nonlinear association between dose and duration of administration and change in blood pressure outcomes, highlighting that maximum SBP and DBP reduction was experienced at 2000 mg/day and 8 weeks of nigella administration, respectively. The present study suggests that nigella supplementation can be beneficial for managing blood pressure. |
| فهرسة مساهمة: | Keywords: Nigella; blood pressure; hypertension; meta-analysis |
| تواريخ الأحداث: | Date Created: 20220817 Date Completed: 20240126 Latest Revision: 20240424 |
| رمز التحديث: | 20240424 |
| DOI: | 10.1080/10408398.2022.2110566 |
| PMID: | 35975622 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1549-7852 |
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| DOI: | 10.1080/10408398.2022.2110566 |